The therapeutic readiness of probiotics in major depressive disorder: A systematic review of randomised controlled trials.

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Title: The therapeutic readiness of probiotics in major depressive disorder: A systematic review of randomised controlled trials.
Authors: Johnson D; Novel Bacteria and Drug Discovery Research Group (NBDD), Microbiome and Bioresource Research Strength (MBRS), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Malaysia.; Pathogen Resistome Virulome and Diagnostic Research Group (PathRiD), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Malaysia., Ramachandram DS; School of Pharmacy, Monash University Malaysia, Bandar Sunway, Malaysia., Doorly J; UCD Intern Network, University College Dublin, Ireland., Clarke G; Department of Psychiatry and Neurobehavioural Science and APC Microbiome Ireland, University College Cork, Ireland., Chan KG; Novel Bacteria and Drug Discovery Research Group (NBDD), Microbiome and Bioresource Research Strength (MBRS), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Malaysia.; Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia., Thurairajasingam S; Clinical School Johor Bahru, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Malaysia., Lee LH; Novel Bacteria and Drug Discovery Research Group (NBDD), Microbiome and Bioresource Research Strength (MBRS), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Malaysia.; Microbiome Research Group, Research Centre for Life Science and Healthcare, Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute (CBI), University of Nottingham Ningbo China, China., Letchumanan V; Novel Bacteria and Drug Discovery Research Group (NBDD), Microbiome and Bioresource Research Strength (MBRS), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Malaysia.; Pathogen Resistome Virulome and Diagnostic Research Group (PathRiD), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Malaysia.
Source: Journal of psychopharmacology (Oxford, England) [J Psychopharmacol] 2026 Apr; Vol. 40 (4), pp. 530-543. Date of Electronic Publication: 2025 Dec 26.
Publication Type: Systematic Review; Journal Article; Review
Journal Info: Publisher: Sage Publications Country of Publication: United States NLM ID: 8907828 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1461-7285 (Electronic) Linking ISSN: 02698811 NLM ISO Abbreviation: J Psychopharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1461-7285
DOI:10.1177/02698811251397332