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Transcriptomic profiling of osteoblasts on hydroxyapatite-coated-metal-surface reveals enhanced osteogenic and angiogenic processes relevant to accelerated bone healing.

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Title: Transcriptomic profiling of osteoblasts on hydroxyapatite-coated-metal-surface reveals enhanced osteogenic and angiogenic processes relevant to accelerated bone healing.
Authors: Ogawa Y; Department of Orthopedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nish-7, Kita-ku, Sapporo, 060-8638, Japan., Arita K; Department of Orthopedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nish-7, Kita-ku, Sapporo, 060-8638, Japan., Nonoyama T; Faculty of Advanced Life Science, Hokkaido University, Kita-21 Nishi-11, Kita-ku, Sapporo, 001-0021, Japan; Co-Creation Core for Soft Materials Aspiring Research & Translation (C3-SMART), Hokkaido University, Kita-21 Nishi-11, Kita-ku, Sapporo, 001-0021, Japan., Sato K; R&D Center, NAKASHIMA HEALTHFORCE, Okayama, Japan., Watanabe R; R&D Center, NAKASHIMA HEALTHFORCE, Okayama, Japan., Chen L; Department of Orthopedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nish-7, Kita-ku, Sapporo, 060-8638, Japan., Endo T; Department of Orthopedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nish-7, Kita-ku, Sapporo, 060-8638, Japan., Tokuhiro T; Department of Orthopedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nish-7, Kita-ku, Sapporo, 060-8638, Japan., Alhasan H; Department of Orthopedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nish-7, Kita-ku, Sapporo, 060-8638, Japan., Takahashi D; Department of Orthopedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nish-7, Kita-ku, Sapporo, 060-8638, Japan., Iwasaki N; Department of Orthopedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nish-7, Kita-ku, Sapporo, 060-8638, Japan., Terkawi MA; Department of Orthopedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nish-7, Kita-ku, Sapporo, 060-8638, Japan. Electronic address: materkawi@med.hokudai.ac.jp.
Source: Biomaterials advances [Biomater Adv] 2026 May; Vol. 182, pp. 214672. Date of Electronic Publication: 2025 Dec 18.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 9918383886206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2772-9508 (Electronic) Linking ISSN: 27729508 NLM ISO Abbreviation: Biomater Adv Subsets: MEDLINE
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  Data: Transcriptomic profiling of osteoblasts on hydroxyapatite-coated-metal-surface reveals enhanced osteogenic and angiogenic processes relevant to accelerated bone healing.
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  Data: <searchLink fieldCode="AU" term="%22Ogawa+Y%22">Ogawa Y</searchLink>; Department of Orthopedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nish-7, Kita-ku, Sapporo, 060-8638, Japan.<br /><searchLink fieldCode="AU" term="%22Arita+K%22">Arita K</searchLink>; Department of Orthopedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nish-7, Kita-ku, Sapporo, 060-8638, Japan.<br /><searchLink fieldCode="AU" term="%22Nonoyama+T%22">Nonoyama T</searchLink>; Faculty of Advanced Life Science, Hokkaido University, Kita-21 Nishi-11, Kita-ku, Sapporo, 001-0021, Japan; Co-Creation Core for Soft Materials Aspiring Research & Translation (C3-SMART), Hokkaido University, Kita-21 Nishi-11, Kita-ku, Sapporo, 001-0021, Japan.<br /><searchLink fieldCode="AU" term="%22Sato+K%22">Sato K</searchLink>; R&D Center, NAKASHIMA HEALTHFORCE, Okayama, Japan.<br /><searchLink fieldCode="AU" term="%22Watanabe+R%22">Watanabe R</searchLink>; R&D Center, NAKASHIMA HEALTHFORCE, Okayama, Japan.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Department of Orthopedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nish-7, Kita-ku, Sapporo, 060-8638, Japan.<br /><searchLink fieldCode="AU" term="%22Endo+T%22">Endo T</searchLink>; Department of Orthopedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nish-7, Kita-ku, Sapporo, 060-8638, Japan.<br /><searchLink fieldCode="AU" term="%22Tokuhiro+T%22">Tokuhiro T</searchLink>; Department of Orthopedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nish-7, Kita-ku, Sapporo, 060-8638, Japan.<br /><searchLink fieldCode="AU" term="%22Alhasan+H%22">Alhasan H</searchLink>; Department of Orthopedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nish-7, Kita-ku, Sapporo, 060-8638, Japan.<br /><searchLink fieldCode="AU" term="%22Takahashi+D%22">Takahashi D</searchLink>; Department of Orthopedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nish-7, Kita-ku, Sapporo, 060-8638, Japan.<br /><searchLink fieldCode="AU" term="%22Iwasaki+N%22">Iwasaki N</searchLink>; Department of Orthopedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nish-7, Kita-ku, Sapporo, 060-8638, Japan.<br /><searchLink fieldCode="AU" term="%22Terkawi+MA%22">Terkawi MA</searchLink>; Department of Orthopedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nish-7, Kita-ku, Sapporo, 060-8638, Japan. Electronic address: materkawi@med.hokudai.ac.jp.
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  Data: <searchLink fieldCode="JN" term="%229918383886206676%22">Biomaterials advances</searchLink> [Biomater Adv] 2026 May; Vol. 182, pp. 214672. <i>Date of Electronic Publication: </i>2025 Dec 18.
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