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Acute fentanyl and xylazine co-exposure uniquely increase the excitability of dopamine type 2 receptor-expressing striatal medium spiny neurons.

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Title: Acute fentanyl and xylazine co-exposure uniquely increase the excitability of dopamine type 2 receptor-expressing striatal medium spiny neurons.
Authors: Yarotskyy V; Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States., Schmitt RM; Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States., Goudsward HJ; Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States., Nass SR; Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States., Harbour K; Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States., McQuiston AR; Department of Neuroscience and Anatomy, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States., Knapp PE; Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States.; Department of Neuroscience and Anatomy, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States.; Institute for Drug and Alcohol Studies, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States., Hauser KF; Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States.; Department of Neuroscience and Anatomy, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States.; Institute for Drug and Alcohol Studies, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States.
Source: Journal of neurophysiology [J Neurophysiol] 2026 Feb 01; Vol. 135 (2), pp. 457-474. Date of Electronic Publication: 2025 Dec 29.
Publication Type: Journal Article
Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 0375404 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1598 (Electronic) Linking ISSN: 00223077 NLM ISO Abbreviation: J Neurophysiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Acute fentanyl and xylazine co-exposure uniquely increase the excitability of dopamine type 2 receptor-expressing striatal medium spiny neurons.
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        Value: 10.1152/jn.00427.2025
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      – TitleFull: Acute fentanyl and xylazine co-exposure uniquely increase the excitability of dopamine type 2 receptor-expressing striatal medium spiny neurons.
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              Text: 2026 Feb 01
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