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SHP2: A Redox-Sensitive Regulator Linking Immune Checkpoint Inhibitor Therapy to Cancer Treatment and Vascular Risk.

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Title: SHP2: A Redox-Sensitive Regulator Linking Immune Checkpoint Inhibitor Therapy to Cancer Treatment and Vascular Risk.
Authors: López Moreno SF; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.; Escuela de Medicina y Ciencias de la Salud, Instituto Tecnológico y de Estudios Superiores de Monterrey, Monterrey 64710, Nuevo León, Mexico., Lenz SA; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.; Escuela de Medicina y Ciencias de la Salud, Instituto Tecnológico y de Estudios Superiores de Monterrey, Monterrey 64710, Nuevo León, Mexico., Casso-Chapa B; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.; Escuela de Medicina y Ciencias de la Salud, Instituto Tecnológico y de Estudios Superiores de Monterrey, Monterrey 64710, Nuevo León, Mexico., Paniagua-Bojorges A; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.; Escuela de Medicina y Ciencias de la Salud, Instituto Tecnológico y de Estudios Superiores de Monterrey, Monterrey 64710, Nuevo León, Mexico., Kim JH; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.; Escuela de Medicina y Ciencias de la Salud, Instituto Tecnológico y de Estudios Superiores de Monterrey, Monterrey 64710, Nuevo León, Mexico., Palaskas NL; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA., Nead KT; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Samanthapudi VSK; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA., Mejia G; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA., Hoang O; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA., Lee J; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.; Department of Pediatric Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Lin SH; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Herrmann J; Cardio Oncology Clinic, Division of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA., Wang G; Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX 77030, USA., Yusuf SW; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA., Iliescu CA; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA., Beinart NI; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA., Manisty C; Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK.; Cardio-Oncology Department, Barts Heart Centre, Barts Health NHS Trust, London EC1A 7BE, UK., Ushio-Fukai M; Department of Medicine, Cardiology, Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA., Fukai T; Department of Medicine, Cardiology, Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA., Ameri P; Cardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy., Nurieva RI; Department of Immunology, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Hildebrandt MAT; Department of Lymphoma/Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Schadler K; Department of Pediatric Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Koutroumpakis E; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA., Kotla S; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA., Le NT; Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX 77030, USA., Abe JI; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.
Source: Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2025 Nov 21; Vol. 14 (12). Date of Electronic Publication: 2025 Nov 21.
Publication Type: Journal Article; Review
Journal Info: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101668981 Publication Model: Electronic Cited Medium: Print ISSN: 2076-3921 (Print) Linking ISSN: 20763921 NLM ISO Abbreviation: Antioxidants (Basel) Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: SHP2: A Redox-Sensitive Regulator Linking Immune Checkpoint Inhibitor Therapy to Cancer Treatment and Vascular Risk.
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  Data: <searchLink fieldCode="AU" term="%22López+Moreno+SF%22">López Moreno SF</searchLink>; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.; Escuela de Medicina y Ciencias de la Salud, Instituto Tecnológico y de Estudios Superiores de Monterrey, Monterrey 64710, Nuevo León, Mexico.<br /><searchLink fieldCode="AU" term="%22Lenz+SA%22">Lenz SA</searchLink>; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.; Escuela de Medicina y Ciencias de la Salud, Instituto Tecnológico y de Estudios Superiores de Monterrey, Monterrey 64710, Nuevo León, Mexico.<br /><searchLink fieldCode="AU" term="%22Casso-Chapa+B%22">Casso-Chapa B</searchLink>; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.; Escuela de Medicina y Ciencias de la Salud, Instituto Tecnológico y de Estudios Superiores de Monterrey, Monterrey 64710, Nuevo León, Mexico.<br /><searchLink fieldCode="AU" term="%22Paniagua-Bojorges+A%22">Paniagua-Bojorges A</searchLink>; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.; Escuela de Medicina y Ciencias de la Salud, Instituto Tecnológico y de Estudios Superiores de Monterrey, Monterrey 64710, Nuevo León, Mexico.<br /><searchLink fieldCode="AU" term="%22Kim+JH%22">Kim JH</searchLink>; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.; Escuela de Medicina y Ciencias de la Salud, Instituto Tecnológico y de Estudios Superiores de Monterrey, Monterrey 64710, Nuevo León, Mexico.<br /><searchLink fieldCode="AU" term="%22Palaskas+NL%22">Palaskas NL</searchLink>; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Nead+KT%22">Nead KT</searchLink>; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Samanthapudi+VSK%22">Samanthapudi VSK</searchLink>; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Mejia+G%22">Mejia G</searchLink>; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Hoang+O%22">Hoang O</searchLink>; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.; Department of Pediatric Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Lin+SH%22">Lin SH</searchLink>; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Herrmann+J%22">Herrmann J</searchLink>; Cardio Oncology Clinic, Division of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Wang+G%22">Wang G</searchLink>; Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Yusuf+SW%22">Yusuf SW</searchLink>; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Iliescu+CA%22">Iliescu CA</searchLink>; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Beinart+NI%22">Beinart NI</searchLink>; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Manisty+C%22">Manisty C</searchLink>; Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK.; Cardio-Oncology Department, Barts Heart Centre, Barts Health NHS Trust, London EC1A 7BE, UK.<br /><searchLink fieldCode="AU" term="%22Ushio-Fukai+M%22">Ushio-Fukai M</searchLink>; Department of Medicine, Cardiology, Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.<br /><searchLink fieldCode="AU" term="%22Fukai+T%22">Fukai T</searchLink>; Department of Medicine, Cardiology, Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.<br /><searchLink fieldCode="AU" term="%22Ameri+P%22">Ameri P</searchLink>; Cardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.<br /><searchLink fieldCode="AU" term="%22Nurieva+RI%22">Nurieva RI</searchLink>; Department of Immunology, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Hildebrandt+MAT%22">Hildebrandt MAT</searchLink>; Department of Lymphoma/Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Schadler+K%22">Schadler K</searchLink>; Department of Pediatric Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Koutroumpakis+E%22">Koutroumpakis E</searchLink>; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Kotla+S%22">Kotla S</searchLink>; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Le+NT%22">Le NT</searchLink>; Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Abe+JI%22">Abe JI</searchLink>; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.
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  Data: <searchLink fieldCode="JN" term="%22101668981%22">Antioxidants (Basel, Switzerland)</searchLink> [Antioxidants (Basel)] 2025 Nov 21; Vol. 14 (12). <i>Date of Electronic Publication: </i>2025 Nov 21.
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