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Phosphoproteomics of aged insulin-resistant bone identifies P70S6K phosphorylation of AFF4 as a gene-specific transcriptional regulator.

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Title: Phosphoproteomics of aged insulin-resistant bone identifies P70S6K phosphorylation of AFF4 as a gene-specific transcriptional regulator.
Authors: Dutt M; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia.; Centre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Victoria, VIC, Australia., Liao L; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia., Kim HJ; Computational Systems Biology Group, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia.; Charles Perkins Centre, School of Mathematics and Statistics, The University of Sydney, Sydney, NSW, Australia.; The Kinghorn Cancer Centre and Cancer Research Theme, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia., Blazev R; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia.; Centre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Victoria, VIC, Australia., Chan A; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia.; Centre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Victoria, VIC, Australia., Kore H; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia.; Centre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Victoria, VIC, Australia., Bezawork-Geleta A; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia., Dong L; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia., Rivera IS; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Wee NKY; St. Vincent's Institute of Medical Research, and Department of Medicine at St. Vincent's Hospital, The University of Melbourne, Fitzroy, VIC, Australia., Molendijk J; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia., Wong JPH; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia.; Centre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Victoria, VIC, Australia., Haynes VR; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia., Uribe V; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia., Lynch GS; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia.; Centre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Victoria, VIC, Australia., Smith KA; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia., Montgomery MK; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia., Watt MJ; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia., Yang P; Computational Systems Biology Group, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia.; Charles Perkins Centre, School of Mathematics and Statistics, The University of Sydney, Sydney, NSW, Australia., Dodd GT; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia., Vervoort SJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Sims NA; St. Vincent's Institute of Medical Research, and Department of Medicine at St. Vincent's Hospital, The University of Melbourne, Fitzroy, VIC, Australia., Parker BL; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia. ben.parker@unimelb.edu.au.; Centre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Victoria, VIC, Australia. ben.parker@unimelb.edu.au.
Source: Nature communications [Nat Commun] 2025 Dec 31; Vol. 17 (1), pp. 1347. Date of Electronic Publication: 2025 Dec 31.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Phosphoproteomics of aged insulin-resistant bone identifies P70S6K phosphorylation of AFF4 as a gene-specific transcriptional regulator.
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  Data: <searchLink fieldCode="AU" term="%22Dutt+M%22">Dutt M</searchLink>; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia.; Centre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Victoria, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Liao+L%22">Liao L</searchLink>; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Kim+HJ%22">Kim HJ</searchLink>; Computational Systems Biology Group, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia.; Charles Perkins Centre, School of Mathematics and Statistics, The University of Sydney, Sydney, NSW, Australia.; The Kinghorn Cancer Centre and Cancer Research Theme, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Blazev+R%22">Blazev R</searchLink>; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia.; Centre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Victoria, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Chan+A%22">Chan A</searchLink>; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia.; Centre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Victoria, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Kore+H%22">Kore H</searchLink>; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia.; 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Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Wong+JPH%22">Wong JPH</searchLink>; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia.; Centre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Victoria, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Haynes+VR%22">Haynes VR</searchLink>; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Uribe+V%22">Uribe V</searchLink>; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Lynch+GS%22">Lynch GS</searchLink>; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia.; Centre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Victoria, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Smith+KA%22">Smith KA</searchLink>; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Montgomery+MK%22">Montgomery MK</searchLink>; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Watt+MJ%22">Watt MJ</searchLink>; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Yang+P%22">Yang P</searchLink>; Computational Systems Biology Group, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia.; Charles Perkins Centre, School of Mathematics and Statistics, The University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Dodd+GT%22">Dodd GT</searchLink>; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Vervoort+SJ%22">Vervoort SJ</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Sims+NA%22">Sims NA</searchLink>; St. Vincent's Institute of Medical Research, and Department of Medicine at St. Vincent's Hospital, The University of Melbourne, Fitzroy, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Parker+BL%22">Parker BL</searchLink>; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia. ben.parker@unimelb.edu.au.; Centre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Victoria, VIC, Australia. ben.parker@unimelb.edu.au.
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