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Predicting acute developmental toxicity of chemicals in embryos of the African clawed frog (Xenopus laevis): Calibration and validation of regression-based quantitative structure activity relationship models for hazard assessment of chemicals in anuran amphibians.

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Title: Predicting acute developmental toxicity of chemicals in embryos of the African clawed frog (Xenopus laevis): Calibration and validation of regression-based quantitative structure activity relationship models for hazard assessment of chemicals in anuran amphibians.
Authors: Novello C; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milano 20156, Italy., Di Nicola MR; Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Bologna 148, Torino 10154, Italy. Electronic address: matteoriccardo.dinicola@izsplv.it., Cm Dorne JL; Chief Scientist Office, European Food Safety Authority (EFSA), Via Carlo Magno 1A, Parma 43126, Italy., Colombo E; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milano 20156, Italy., Viganò EL; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milano 20156, Italy., Ortiz-Santaliestra ME; Instituto de Investigación en Recursos Cinegéticos (IREC) UCLM-CSIC-JCCM, de Toledo 12, Ronda, Ciudad Real 13005, Spain., Kramer N; Toxicology Division, Wageningen University, PO Box 8000, Wageningen 6700 EA, the Netherlands., Carnesecchi E; iDATA Unit, European Food Safety Authority (EFSA), Via Carlo Magno 1A, Parma 43126, Italy., Steinbach AM; German Federal Institute for Risk Assessment (BfR), Max-Dohrn-Straße 8-10, Berlin 10589, Germany., Eberini I; University of Milan, Dipartimento di Scienze farmacologiche e biomolecolari, Via Balzaretti 9, Milan 20133, Italy., Williams A; Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency (US EPA), Research Triangle Park, Raleigh, USA., Benfenati E; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milano 20156, Italy., Roncaglioni A; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milano 20156, Italy.
Source: Toxicology letters [Toxicol Lett] 2026 Feb; Vol. 416, pp. 111813. Date of Electronic Publication: 2026 Jan 01.
Publication Type: Journal Article; Validation Study
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7709027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3169 (Electronic) Linking ISSN: 03784274 NLM ISO Abbreviation: Toxicol Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Predicting acute developmental toxicity of chemicals in embryos of the African clawed frog (Xenopus laevis): Calibration and validation of regression-based quantitative structure activity relationship models for hazard assessment of chemicals in anuran amphibians.
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  Data: <searchLink fieldCode="AU" term="%22Novello+C%22">Novello C</searchLink>; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milano 20156, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Nicola+MR%22">Di Nicola MR</searchLink>; Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Bologna 148, Torino 10154, Italy. Electronic address: matteoriccardo.dinicola@izsplv.it.<br /><searchLink fieldCode="AU" term="%22Cm+Dorne+JL%22">Cm Dorne JL</searchLink>; Chief Scientist Office, European Food Safety Authority (EFSA), Via Carlo Magno 1A, Parma 43126, Italy.<br /><searchLink fieldCode="AU" term="%22Colombo+E%22">Colombo E</searchLink>; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milano 20156, Italy.<br /><searchLink fieldCode="AU" term="%22Viganò+EL%22">Viganò EL</searchLink>; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milano 20156, Italy.<br /><searchLink fieldCode="AU" term="%22Ortiz-Santaliestra+ME%22">Ortiz-Santaliestra ME</searchLink>; Instituto de Investigación en Recursos Cinegéticos (IREC) UCLM-CSIC-JCCM, de Toledo 12, Ronda, Ciudad Real 13005, Spain.<br /><searchLink fieldCode="AU" term="%22Kramer+N%22">Kramer N</searchLink>; Toxicology Division, Wageningen University, PO Box 8000, Wageningen 6700 EA, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Carnesecchi+E%22">Carnesecchi E</searchLink>; iDATA Unit, European Food Safety Authority (EFSA), Via Carlo Magno 1A, Parma 43126, Italy.<br /><searchLink fieldCode="AU" term="%22Steinbach+AM%22">Steinbach AM</searchLink>; German Federal Institute for Risk Assessment (BfR), Max-Dohrn-Straße 8-10, Berlin 10589, Germany.<br /><searchLink fieldCode="AU" term="%22Eberini+I%22">Eberini I</searchLink>; University of Milan, Dipartimento di Scienze farmacologiche e biomolecolari, Via Balzaretti 9, Milan 20133, Italy.<br /><searchLink fieldCode="AU" term="%22Williams+A%22">Williams A</searchLink>; Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency (US EPA), Research Triangle Park, Raleigh, USA.<br /><searchLink fieldCode="AU" term="%22Benfenati+E%22">Benfenati E</searchLink>; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milano 20156, Italy.<br /><searchLink fieldCode="AU" term="%22Roncaglioni+A%22">Roncaglioni A</searchLink>; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milano 20156, Italy.
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