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Agitation and anxiety features define a more severe phenotype in unipolar depression.

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Title: Agitation and anxiety features define a more severe phenotype in unipolar depression.
Authors: Luca M; Centre for Addiction, Adrano-Bronte, Via Po' 2, 95031 Adrano, Italy., Luca A; Department of Medicine and Surgery, Kore University of Enna, Cittadella Universitaria 94100 Enna, Italy., Barlati S; Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy; Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123 Brescia, Italy., Buson L; Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Via Pilastroni 4, 25125 Brescia, Italy., Menesello V; Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Via Pilastroni 4, 25125 Brescia, Italy; Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy., Magistrali A; Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy., Silva RC; Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy., Perusi G; Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Via Pilastroni 4, 25125 Brescia, Italy., Nibbio G; Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123 Brescia, Italy., Bignotti S; Psychiatry Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Via Pilastroni 4, 25125 Brescia, Italy., Tura GB; Psychiatry Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Via Pilastroni 4, 25125 Brescia, Italy., Ferri R; Oasi Research Institute-IRCCS, Via Conte Ruggero 73, 94018 Troina, Italy., Gennarelli M; Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Via Pilastroni 4, 25125 Brescia, Italy; Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy., Vita A; Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy; Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123 Brescia, Italy., Souery D; Psy Pluriel - Epsylon caring for mental health Brussels and Laboratoire de Psychologie Médicale Université libre de Bruxelles, Campus Erasme, 1070 Brussels, Belgium., Kasper S; Department of Psychiatry and Psychotherapy, Medical University Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria; Center for Brain Research, Department of Molecular Neuroscience, Medical University Vienna, Spitalgasse 4, 1090 Vienna, Austria., Zohar J; Department of Psychiatry, Sheba Medical Center, Tel Hashomer, and Sackler School of Medicine, Tel Aviv University, Ramat Aviv, 69978 Tel Aviv, Israel., Montgomery S; Imperial College School of Medicine, South Kensington Campus, SW7 2AZ London, UK., Ferentinos P; Department of Psychiatry, Athens University Medical School, Sophias Avenue, 11528 Athens, Greece., Rujescu D; Department of Psychiatry and Psychotherapy, Medical University Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria., Zanardi R; Department of Clinical Neurosciences, Mood Disorder Unit, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy; Department of Clinical Neurosciences, Vita-Salute San Raffaele University, Via Olgettina 58, 20132 Milan, Italy., Mendlewicz J; Université Libre de Bruxelles, Avenue Franklin Roosevelt 50, 1050 Brussels, Belgium., Minelli A; Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Via Pilastroni 4, 25125 Brescia, Italy; Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy., Serretti A; Department of Medicine and Surgery, Kore University of Enna, Cittadella Universitaria 94100 Enna, Italy; Oasi Research Institute-IRCCS, Via Conte Ruggero 73, 94018 Troina, Italy. Electronic address: alessandro.serretti@icloud.com.
Corporate Authors: PANDORA Study Group
Source: Psychiatry research [Psychiatry Res] 2026 Mar; Vol. 357, pp. 116928. Date of Electronic Publication: 2025 Dec 30.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Ireland NLM ID: 7911385 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7123 (Electronic) Linking ISSN: 01651781 NLM ISO Abbreviation: Psychiatry Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Agitation and anxiety features define a more severe phenotype in unipolar depression.
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  Data: <searchLink fieldCode="AU" term="%22Luca+M%22">Luca M</searchLink>; Centre for Addiction, Adrano-Bronte, Via Po' 2, 95031 Adrano, Italy.<br /><searchLink fieldCode="AU" term="%22Luca+A%22">Luca A</searchLink>; Department of Medicine and Surgery, Kore University of Enna, Cittadella Universitaria 94100 Enna, Italy.<br /><searchLink fieldCode="AU" term="%22Barlati+S%22">Barlati S</searchLink>; Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy; Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Buson+L%22">Buson L</searchLink>; Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Via Pilastroni 4, 25125 Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Menesello+V%22">Menesello V</searchLink>; Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Via Pilastroni 4, 25125 Brescia, Italy; Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Magistrali+A%22">Magistrali A</searchLink>; Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Silva+RC%22">Silva RC</searchLink>; Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Perusi+G%22">Perusi G</searchLink>; Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Via Pilastroni 4, 25125 Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Nibbio+G%22">Nibbio G</searchLink>; Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Bignotti+S%22">Bignotti S</searchLink>; Psychiatry Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Via Pilastroni 4, 25125 Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Tura+GB%22">Tura GB</searchLink>; Psychiatry Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Via Pilastroni 4, 25125 Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Ferri+R%22">Ferri R</searchLink>; Oasi Research Institute-IRCCS, Via Conte Ruggero 73, 94018 Troina, Italy.<br /><searchLink fieldCode="AU" term="%22Gennarelli+M%22">Gennarelli M</searchLink>; Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Via Pilastroni 4, 25125 Brescia, Italy; Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Vita+A%22">Vita A</searchLink>; Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy; Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Souery+D%22">Souery D</searchLink>; Psy Pluriel - Epsylon caring for mental health Brussels and Laboratoire de Psychologie Médicale Université libre de Bruxelles, Campus Erasme, 1070 Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Kasper+S%22">Kasper S</searchLink>; Department of Psychiatry and Psychotherapy, Medical University Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria; Center for Brain Research, Department of Molecular Neuroscience, Medical University Vienna, Spitalgasse 4, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Zohar+J%22">Zohar J</searchLink>; Department of Psychiatry, Sheba Medical Center, Tel Hashomer, and Sackler School of Medicine, Tel Aviv University, Ramat Aviv, 69978 Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Montgomery+S%22">Montgomery S</searchLink>; Imperial College School of Medicine, South Kensington Campus, SW7 2AZ London, UK.<br /><searchLink fieldCode="AU" term="%22Ferentinos+P%22">Ferentinos P</searchLink>; Department of Psychiatry, Athens University Medical School, Sophias Avenue, 11528 Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Rujescu+D%22">Rujescu D</searchLink>; Department of Psychiatry and Psychotherapy, Medical University Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Zanardi+R%22">Zanardi R</searchLink>; Department of Clinical Neurosciences, Mood Disorder Unit, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy; Department of Clinical Neurosciences, Vita-Salute San Raffaele University, Via Olgettina 58, 20132 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Mendlewicz+J%22">Mendlewicz J</searchLink>; Université Libre de Bruxelles, Avenue Franklin Roosevelt 50, 1050 Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Minelli+A%22">Minelli A</searchLink>; Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Via Pilastroni 4, 25125 Brescia, Italy; Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Serretti+A%22">Serretti A</searchLink>; Department of Medicine and Surgery, Kore University of Enna, Cittadella Universitaria 94100 Enna, Italy; Oasi Research Institute-IRCCS, Via Conte Ruggero 73, 94018 Troina, Italy. Electronic address: alessandro.serretti@icloud.com.
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