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GASDERMIN D-mediated pyroptosis as a therapeutic target in TAU-dependent frontotemporal dementia mouse model.

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Title: GASDERMIN D-mediated pyroptosis as a therapeutic target in TAU-dependent frontotemporal dementia mouse model.
Authors: Silva-Llanes I; Instituto de Investigaciones Biomédicas 'Sols-Morreale' CSIC-UAM, C/ Arturo Duperier, 4, 28029, Madrid, Spain.; Instituto de Investigación Sanitaria La Paz (IdiPaz), Madrid, Spain., Smith LA; Instituto de Investigaciones Biomédicas 'Sols-Morreale' CSIC-UAM, C/ Arturo Duperier, 4, 28029, Madrid, Spain.; Instituto de Investigación Sanitaria La Paz (IdiPaz), Madrid, Spain., Abdelkader-Guillén A; Instituto de Investigaciones Biomédicas 'Sols-Morreale' CSIC-UAM, C/ Arturo Duperier, 4, 28029, Madrid, Spain.; Instituto de Investigación Sanitaria La Paz (IdiPaz), Madrid, Spain., Jiménez-Villegas J; Instituto de Investigaciones Biomédicas 'Sols-Morreale' CSIC-UAM, C/ Arturo Duperier, 4, 28029, Madrid, Spain.; Instituto de Investigación Sanitaria La Paz (IdiPaz), Madrid, Spain.; Centro de Investigación Biomédica en Red, Área Enfermedades Neurodegenerativas, CIBERNED, Instituto de Salud Carlos III, 28029, Madrid, Spain., Sarrió D; Instituto de Investigaciones Biomédicas 'Sols-Morreale' CSIC-UAM, C/ Arturo Duperier, 4, 28029, Madrid, Spain.; Translational Cancer Research Group, Area 3 Cancer, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034, Madrid, Spain.; Centro de Investigación Biomédica en Red, Área Cáncer, CIBERONC, Instituto de Salud Carlos III, 28029, Madrid, Spain., Moreno-Bueno G; Instituto de Investigaciones Biomédicas 'Sols-Morreale' CSIC-UAM, C/ Arturo Duperier, 4, 28029, Madrid, Spain.; Translational Cancer Research Group, Area 3 Cancer, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034, Madrid, Spain.; Centro de Investigación Biomédica en Red, Área Cáncer, CIBERONC, Instituto de Salud Carlos III, 28029, Madrid, Spain.; Fundación MD Anderson Internacional, 28033, Madrid, Spain., Lastres-Becker I; Instituto de Investigaciones Biomédicas 'Sols-Morreale' CSIC-UAM, C/ Arturo Duperier, 4, 28029, Madrid, Spain. ilbecker@iib.uam.es.; Instituto de Investigación Sanitaria La Paz (IdiPaz), Madrid, Spain. ilbecker@iib.uam.es.; Centro de Investigación Biomédica en Red, Área Enfermedades Neurodegenerativas, CIBERNED, Instituto de Salud Carlos III, 28029, Madrid, Spain. ilbecker@iib.uam.es.
Source: Journal of biomedical science [J Biomed Sci] 2026 Jan 05; Vol. 33 (1), pp. 6. Date of Electronic Publication: 2026 Jan 05.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9421567 Publication Model: Electronic Cited Medium: Internet ISSN: 1423-0127 (Electronic) Linking ISSN: 10217770 NLM ISO Abbreviation: J Biomed Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: GASDERMIN D-mediated pyroptosis as a therapeutic target in TAU-dependent frontotemporal dementia mouse model.
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  Data: <searchLink fieldCode="AU" term="%22Silva-Llanes+I%22">Silva-Llanes I</searchLink>; Instituto de Investigaciones Biomédicas 'Sols-Morreale' CSIC-UAM, C/ Arturo Duperier, 4, 28029, Madrid, Spain.; Instituto de Investigación Sanitaria La Paz (IdiPaz), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Smith+LA%22">Smith LA</searchLink>; Instituto de Investigaciones Biomédicas 'Sols-Morreale' CSIC-UAM, C/ Arturo Duperier, 4, 28029, Madrid, Spain.; Instituto de Investigación Sanitaria La Paz (IdiPaz), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Abdelkader-Guillén+A%22">Abdelkader-Guillén A</searchLink>; Instituto de Investigaciones Biomédicas 'Sols-Morreale' CSIC-UAM, C/ Arturo Duperier, 4, 28029, Madrid, Spain.; Instituto de Investigación Sanitaria La Paz (IdiPaz), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Jiménez-Villegas+J%22">Jiménez-Villegas J</searchLink>; Instituto de Investigaciones Biomédicas 'Sols-Morreale' CSIC-UAM, C/ Arturo Duperier, 4, 28029, Madrid, Spain.; Instituto de Investigación Sanitaria La Paz (IdiPaz), Madrid, Spain.; Centro de Investigación Biomédica en Red, Área Enfermedades Neurodegenerativas, CIBERNED, Instituto de Salud Carlos III, 28029, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Sarrió+D%22">Sarrió D</searchLink>; Instituto de Investigaciones Biomédicas 'Sols-Morreale' CSIC-UAM, C/ Arturo Duperier, 4, 28029, Madrid, Spain.; Translational Cancer Research Group, Area 3 Cancer, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034, Madrid, Spain.; Centro de Investigación Biomédica en Red, Área Cáncer, CIBERONC, Instituto de Salud Carlos III, 28029, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Moreno-Bueno+G%22">Moreno-Bueno G</searchLink>; Instituto de Investigaciones Biomédicas 'Sols-Morreale' CSIC-UAM, C/ Arturo Duperier, 4, 28029, Madrid, Spain.; Translational Cancer Research Group, Area 3 Cancer, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034, Madrid, Spain.; Centro de Investigación Biomédica en Red, Área Cáncer, CIBERONC, Instituto de Salud Carlos III, 28029, Madrid, Spain.; Fundación MD Anderson Internacional, 28033, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Lastres-Becker+I%22">Lastres-Becker I</searchLink>; Instituto de Investigaciones Biomédicas 'Sols-Morreale' CSIC-UAM, C/ Arturo Duperier, 4, 28029, Madrid, Spain. ilbecker@iib.uam.es.; Instituto de Investigación Sanitaria La Paz (IdiPaz), Madrid, Spain. ilbecker@iib.uam.es.; Centro de Investigación Biomédica en Red, Área Enfermedades Neurodegenerativas, CIBERNED, Instituto de Salud Carlos III, 28029, Madrid, Spain. ilbecker@iib.uam.es.
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