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Frequent and clinically relevant germline DNA repair gene variants in young and familial myeloproliferative neoplasms.

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Title: Frequent and clinically relevant germline DNA repair gene variants in young and familial myeloproliferative neoplasms.
Authors: Meyer R; Center for Human Genetics and Genomic Medicine, Medical Faculty, RWTH Aachen University, Aachen, Germany. rmeyer@ukaachen.de.; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany. rmeyer@ukaachen.de., Rodriguez MJ; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany., Caduc M; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany., Kricheldorf K; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany., Begemann M; Center for Human Genetics and Genomic Medicine, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany., Kraft F; Center for Human Genetics and Genomic Medicine, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany., Spier I; National Center for Hereditary Tumour Syndromes, University Hospital Bonn, and Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Bonn, Germany.; Institute of Human Genetics, Medical Faculty, University of Bonn, Bonn, Germany.; European Reference Network on Genetic Tumour Risk Syndromes (ERN GENTURIS), Bonn, Germany., Dey D; Center for Human Genetics and Genomic Medicine, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany., Güzel N; Center for Human Genetics and Genomic Medicine, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany., Becker K; West German Genome Center (WGGC), Cologne, Germany.; Cologne Center for Genomics (CCG), Medical Faculty, University of Cologne, Cologne, Germany., Baumeister J; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany., S de Toledo MA; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany., Isfort S; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Comprehensive Cancer Center Lower-Saxony (CCC-N), Hannover Medical School (MHH), Hannover, Germany., Germing U; Department of Hematology, Oncology and Clinical Immunology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Düsseldorf, Germany., Aretz S; National Center for Hereditary Tumour Syndromes, University Hospital Bonn, and Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Bonn, Germany.; Institute of Human Genetics, Medical Faculty, University of Bonn, Bonn, Germany.; European Reference Network on Genetic Tumour Risk Syndromes (ERN GENTURIS), Bonn, Germany., Brümmendorf TH; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany., Kurth I; Center for Human Genetics and Genomic Medicine, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany., Elbracht M; Center for Human Genetics and Genomic Medicine, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany., Teichmann LL; Department of Medicine III, University Hospital Bonn, Bonn, Germany.; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Bonn, Germany., Koschmieder S; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Source: Blood cancer journal [Blood Cancer J] 2026 Jan 05; Vol. 16 (1), pp. 2. Date of Electronic Publication: 2026 Jan 05.
Publication Type: Letter
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101568469 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-5385 (Electronic) Linking ISSN: 20445385 NLM ISO Abbreviation: Blood Cancer J Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
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  Data: Frequent and clinically relevant germline DNA repair gene variants in young and familial myeloproliferative neoplasms.
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  Data: <searchLink fieldCode="AU" term="%22Meyer+R%22">Meyer R</searchLink>; Center for Human Genetics and Genomic Medicine, Medical Faculty, RWTH Aachen University, Aachen, Germany. rmeyer@ukaachen.de.; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany. rmeyer@ukaachen.de.<br /><searchLink fieldCode="AU" term="%22Rodriguez+MJ%22">Rodriguez MJ</searchLink>; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Caduc+M%22">Caduc M</searchLink>; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Kricheldorf+K%22">Kricheldorf K</searchLink>; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Begemann+M%22">Begemann M</searchLink>; Center for Human Genetics and Genomic Medicine, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Kraft+F%22">Kraft F</searchLink>; Center for Human Genetics and Genomic Medicine, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Spier+I%22">Spier I</searchLink>; National Center for Hereditary Tumour Syndromes, University Hospital Bonn, and Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Bonn, Germany.; Institute of Human Genetics, Medical Faculty, University of Bonn, Bonn, Germany.; European Reference Network on Genetic Tumour Risk Syndromes (ERN GENTURIS), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Dey+D%22">Dey D</searchLink>; Center for Human Genetics and Genomic Medicine, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Güzel+N%22">Güzel N</searchLink>; Center for Human Genetics and Genomic Medicine, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Becker+K%22">Becker K</searchLink>; West German Genome Center (WGGC), Cologne, Germany.; Cologne Center for Genomics (CCG), Medical Faculty, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Baumeister+J%22">Baumeister J</searchLink>; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22S+de+Toledo+MA%22">S de Toledo MA</searchLink>; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Isfort+S%22">Isfort S</searchLink>; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Comprehensive Cancer Center Lower-Saxony (CCC-N), Hannover Medical School (MHH), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Germing+U%22">Germing U</searchLink>; Department of Hematology, Oncology and Clinical Immunology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Aretz+S%22">Aretz S</searchLink>; National Center for Hereditary Tumour Syndromes, University Hospital Bonn, and Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Bonn, Germany.; Institute of Human Genetics, Medical Faculty, University of Bonn, Bonn, Germany.; European Reference Network on Genetic Tumour Risk Syndromes (ERN GENTURIS), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Brümmendorf+TH%22">Brümmendorf TH</searchLink>; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Kurth+I%22">Kurth I</searchLink>; Center for Human Genetics and Genomic Medicine, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Elbracht+M%22">Elbracht M</searchLink>; Center for Human Genetics and Genomic Medicine, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Teichmann+LL%22">Teichmann LL</searchLink>; Department of Medicine III, University Hospital Bonn, Bonn, Germany.; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Koschmieder+S%22">Koschmieder S</searchLink>; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101568469%22">Blood cancer journal</searchLink> [Blood Cancer J] 2026 Jan 05; Vol. 16 (1), pp. 2. <i>Date of Electronic Publication: </i>2026 Jan 05.
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