Vessels encapsulating tumor clusters promote noninvasive metastasis of hepatocellular carcinoma by shaping an immunosuppressive microenvironment.

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Title: Vessels encapsulating tumor clusters promote noninvasive metastasis of hepatocellular carcinoma by shaping an immunosuppressive microenvironment.
Authors: Huang BY; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China., Mi ZQ; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China., Zhang XY; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China., Ji YC; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China., Wu MZ; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China., Cheng ZF; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China., Xie C; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China., He S; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer and., Zhu J; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China., Fang JH; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China., Wu C; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China., Li BK; Department of Hepatobiliary Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China., Yuan YF; Department of Hepatobiliary Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China., Zheng L; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China., Zhuang SM; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China.
Source: The Journal of clinical investigation [J Clin Invest] 2026 Jan 06; Vol. 136 (4). Date of Electronic Publication: 2026 Jan 06 (Print Publication: 2026).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 41493808
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PubType: Academic Journal
PubTypeId: academicJournal
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Vessels encapsulating tumor clusters promote noninvasive metastasis of hepatocellular carcinoma by shaping an immunosuppressive microenvironment.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Huang+BY%22">Huang BY</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Mi+ZQ%22">Mi ZQ</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+XY%22">Zhang XY</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Ji+YC%22">Ji YC</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wu+MZ%22">Wu MZ</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Cheng+ZF%22">Cheng ZF</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Xie+C%22">Xie C</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22He+S%22">He S</searchLink>; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer and.<br /><searchLink fieldCode="AU" term="%22Zhu+J%22">Zhu J</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Fang+JH%22">Fang JH</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wu+C%22">Wu C</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+BK%22">Li BK</searchLink>; Department of Hepatobiliary Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Yuan+YF%22">Yuan YF</searchLink>; Department of Hepatobiliary Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zheng+L%22">Zheng L</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhuang+SM%22">Zhuang SM</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China.
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  Label: Source
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  Data: <searchLink fieldCode="JN" term="%227802877%22">The Journal of clinical investigation</searchLink> [J Clin Invest] 2026 Jan 06; Vol. 136 (4). <i>Date of Electronic Publication: </i>2026 Jan 06 (<i>Print Publication: </i>2026).
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  Data: Journal Article; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Clinical+Investigation%22">American Society for Clinical Investigation </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7802877 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1558-8238 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219738%22">00219738 </searchLink><i>NLM ISO Abbreviation: </i>J Clin Invest <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41493808
RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1172/JCI193758
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: Vessels encapsulating tumor clusters promote noninvasive metastasis of hepatocellular carcinoma by shaping an immunosuppressive microenvironment.
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            – D: 06
              M: 01
              Text: 2026 Jan 06
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              Y: 2026
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