Elucidation of mechanisms underlying the therapeutic effects of cordycepin on pulmonary hypertension, with a focus on cell senescence and gut microbiota.

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Title: Elucidation of mechanisms underlying the therapeutic effects of cordycepin on pulmonary hypertension, with a focus on cell senescence and gut microbiota.
Authors: Li G; Department of Cardiovascular Physiology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan., Zhao Z; Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia 010018, China., Machitani M; Division of Cancer Stem Cell, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-Ku, Tokyo 104-0045, Japan., Ishikawa R; Department of Diagnostic Pathology, Kagawa University Hospital, Kagawa 761-0793, Japan., Ishikawa K; Department of General Medicine, Kagawa University Hospital, Kagawa 761-0793, Japan., Yokota N; Department of General Thoracic Surgery, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan., Haba R; Department of Diagnostic Pathology, Kagawa University Hospital, Kagawa 761-0793, Japan., Nakamura K; Center for Advanced Heart Failure, Okayama University Hospital, Okayama 700-8558, Japan., Sun Z; Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia 010018, China., Kurahara LH; Department of Cardiovascular Physiology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan. Electronic address: kurahara.rin@kagawa-u.ac.jp., Hirano K; Department of Cardiovascular Physiology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2026 Jan; Vol. 194, pp. 118923. Date of Electronic Publication: 2026 Jan 06.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
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  Data: Elucidation of mechanisms underlying the therapeutic effects of cordycepin on pulmonary hypertension, with a focus on cell senescence and gut microbiota.
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  Data: <searchLink fieldCode="AU" term="%22Li+G%22">Li G</searchLink>; Department of Cardiovascular Physiology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.<br /><searchLink fieldCode="AU" term="%22Zhao+Z%22">Zhao Z</searchLink>; Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia 010018, China.<br /><searchLink fieldCode="AU" term="%22Machitani+M%22">Machitani M</searchLink>; Division of Cancer Stem Cell, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-Ku, Tokyo 104-0045, Japan.<br /><searchLink fieldCode="AU" term="%22Ishikawa+R%22">Ishikawa R</searchLink>; Department of Diagnostic Pathology, Kagawa University Hospital, Kagawa 761-0793, Japan.<br /><searchLink fieldCode="AU" term="%22Ishikawa+K%22">Ishikawa K</searchLink>; Department of General Medicine, Kagawa University Hospital, Kagawa 761-0793, Japan.<br /><searchLink fieldCode="AU" term="%22Yokota+N%22">Yokota N</searchLink>; Department of General Thoracic Surgery, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.<br /><searchLink fieldCode="AU" term="%22Haba+R%22">Haba R</searchLink>; Department of Diagnostic Pathology, Kagawa University Hospital, Kagawa 761-0793, Japan.<br /><searchLink fieldCode="AU" term="%22Nakamura+K%22">Nakamura K</searchLink>; Center for Advanced Heart Failure, Okayama University Hospital, Okayama 700-8558, Japan.<br /><searchLink fieldCode="AU" term="%22Sun+Z%22">Sun Z</searchLink>; Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia 010018, China.<br /><searchLink fieldCode="AU" term="%22Kurahara+LH%22">Kurahara LH</searchLink>; Department of Cardiovascular Physiology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan. Electronic address: kurahara.rin@kagawa-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Hirano+K%22">Hirano K</searchLink>; Department of Cardiovascular Physiology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.
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  Data: <searchLink fieldCode="JN" term="%228213295%22">Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie</searchLink> [Biomed Pharmacother] 2026 Jan; Vol. 194, pp. 118923. <i>Date of Electronic Publication: </i>2026 Jan 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editions+Scientifiques+Elsevier%22">Editions Scientifiques Elsevier </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>8213295 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1950-6007 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2207533322%22">07533322 </searchLink><i>NLM ISO Abbreviation: </i>Biomed Pharmacother <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.biopha.2025.118923
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              Text: 2026 Jan
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