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Estrogen signaling in PDGFRα+ cells positively regulates cortical bone metabolism via IGFBP5 in female mice.

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Title: Estrogen signaling in PDGFRα+ cells positively regulates cortical bone metabolism via IGFBP5 in female mice.
Authors: Ikedo A; Division of Integrative Pathophysiology, Proteo-Science Center, PIAS, Ehime University, Toon 791-0295, Japan., Aoki R; Department of Hepato-Biliary-Pancreatic Surgery and Breast Surgery, Ehime University Graduate School of Medicine, Toon 791-0295, Japan., Sakai H; Division of Integrative Pathophysiology, Proteo-Science Center, PIAS, Ehime University, Toon 791-0295, Japan.; Department of Pathophysiology, Ehime University Graduate School of Medicine, Toon 791-0295, Japan., Saeki N; Division of Integrative Pathophysiology, Proteo-Science Center, PIAS, Ehime University, Toon 791-0295, Japan.; Division of Medical Research Support, Advanced Research Support Center, Ehime University, Toon 791-0295, Japan., Yanagihara Y; Division of Integrative Pathophysiology, Proteo-Science Center, PIAS, Ehime University, Toon 791-0295, Japan., Moody J; Laboratory for Regulatory Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan., Kojima M; Laboratory for Regulatory Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan., Kouno T; Laboratory for Regulatory Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan., Ando Y; Laboratory for Regulatory Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan., Hino K; Department of Orthopaedic Surgery, Ehime University Graduate School of Medicine, Toon 791-0295, Japan., Kinoshita T; Department of Orthopaedic Surgery, Ehime University Graduate School of Medicine, Toon 791-0295, Japan., Carninci P; Laboratory for Regulatory Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.; Human Technopole, 20157 Milan, Italy., Shin JW; Laboratory for Regulatory Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore  138672.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore  117597., Hon CC; Laboratory for Regulatory Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan., Uezumi A; Divison of Cell Heterogeneity, Medical Research Center for High Depth Omics, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-0054, Japan., Kamei Y; Department of Hepato-Biliary-Pancreatic Surgery and Breast Surgery, Ehime University Graduate School of Medicine, Toon 791-0295, Japan., Imai Y; Division of Integrative Pathophysiology, Proteo-Science Center, PIAS, Ehime University, Toon 791-0295, Japan.; Department of Pathophysiology, Ehime University Graduate School of Medicine, Toon 791-0295, Japan.
Source: JBMR plus [JBMR Plus] 2025 Nov 07; Vol. 10 (1), pp. ziaf178. Date of Electronic Publication: 2025 Nov 07 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101707013 Publication Model: eCollection Cited Medium: Internet ISSN: 2473-4039 (Electronic) Linking ISSN: 24734039 NLM ISO Abbreviation: JBMR Plus Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Estrogen signaling in PDGFRα+ cells positively regulates cortical bone metabolism via IGFBP5 in female mice.
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  Data: <searchLink fieldCode="AU" term="%22Ikedo+A%22">Ikedo A</searchLink>; Division of Integrative Pathophysiology, Proteo-Science Center, PIAS, Ehime University, Toon 791-0295, Japan.<br /><searchLink fieldCode="AU" term="%22Aoki+R%22">Aoki R</searchLink>; Department of Hepato-Biliary-Pancreatic Surgery and Breast Surgery, Ehime University Graduate School of Medicine, Toon 791-0295, Japan.<br /><searchLink fieldCode="AU" term="%22Sakai+H%22">Sakai H</searchLink>; Division of Integrative Pathophysiology, Proteo-Science Center, PIAS, Ehime University, Toon 791-0295, Japan.; Department of Pathophysiology, Ehime University Graduate School of Medicine, Toon 791-0295, Japan.<br /><searchLink fieldCode="AU" term="%22Saeki+N%22">Saeki N</searchLink>; Division of Integrative Pathophysiology, Proteo-Science Center, PIAS, Ehime University, Toon 791-0295, Japan.; Division of Medical Research Support, Advanced Research Support Center, Ehime University, Toon 791-0295, Japan.<br /><searchLink fieldCode="AU" term="%22Yanagihara+Y%22">Yanagihara Y</searchLink>; Division of Integrative Pathophysiology, Proteo-Science Center, PIAS, Ehime University, Toon 791-0295, Japan.<br /><searchLink fieldCode="AU" term="%22Moody+J%22">Moody J</searchLink>; Laboratory for Regulatory Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.<br /><searchLink fieldCode="AU" term="%22Kojima+M%22">Kojima M</searchLink>; Laboratory for Regulatory Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.<br /><searchLink fieldCode="AU" term="%22Kouno+T%22">Kouno T</searchLink>; Laboratory for Regulatory Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.<br /><searchLink fieldCode="AU" term="%22Ando+Y%22">Ando Y</searchLink>; Laboratory for Regulatory Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.<br /><searchLink fieldCode="AU" term="%22Hino+K%22">Hino K</searchLink>; Department of Orthopaedic Surgery, Ehime University Graduate School of Medicine, Toon 791-0295, Japan.<br /><searchLink fieldCode="AU" term="%22Kinoshita+T%22">Kinoshita T</searchLink>; Department of Orthopaedic Surgery, Ehime University Graduate School of Medicine, Toon 791-0295, Japan.<br /><searchLink fieldCode="AU" term="%22Carninci+P%22">Carninci P</searchLink>; Laboratory for Regulatory Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.; Human Technopole, 20157 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Shin+JW%22">Shin JW</searchLink>; Laboratory for Regulatory Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore  138672.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore  117597.<br /><searchLink fieldCode="AU" term="%22Hon+CC%22">Hon CC</searchLink>; Laboratory for Regulatory Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.<br /><searchLink fieldCode="AU" term="%22Uezumi+A%22">Uezumi A</searchLink>; Divison of Cell Heterogeneity, Medical Research Center for High Depth Omics, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-0054, Japan.<br /><searchLink fieldCode="AU" term="%22Kamei+Y%22">Kamei Y</searchLink>; Department of Hepato-Biliary-Pancreatic Surgery and Breast Surgery, Ehime University Graduate School of Medicine, Toon 791-0295, Japan.<br /><searchLink fieldCode="AU" term="%22Imai+Y%22">Imai Y</searchLink>; Division of Integrative Pathophysiology, Proteo-Science Center, PIAS, Ehime University, Toon 791-0295, Japan.; Department of Pathophysiology, Ehime University Graduate School of Medicine, Toon 791-0295, Japan.
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  Data: <searchLink fieldCode="JN" term="%22101707013%22">JBMR plus</searchLink> [JBMR Plus] 2025 Nov 07; Vol. 10 (1), pp. ziaf178. <i>Date of Electronic Publication: </i>2025 Nov 07 (<i>Print Publication: </i>2026).
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