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DNA-Loaded Nanoparticles Reprogram the Tumor Immune Microenvironment to Treat Brain Tumors.

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Title: DNA-Loaded Nanoparticles Reprogram the Tumor Immune Microenvironment to Treat Brain Tumors.
Authors: Yang J; Department of Biomedical Engineering Johns Hopkins University School of Medicine Baltimore MD 21231 USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center Johns Hopkins University School of Medicine Baltimore MD 21231 USA., Raj D; Department of Neurosurgery Johns Hopkins University School of Medicine Baltimore MD 21205 USA., Slika H; Department of Neurosurgery Johns Hopkins University School of Medicine Baltimore MD 21205 USA., Shahani A; Department of Neurosurgery Johns Hopkins University School of Medicine Baltimore MD 21205 USA., Cheng L; Translational ImmunoEngineering Center, Translational Tissue Engineering Center Johns Hopkins University School of Medicine Baltimore MD 21231 USA.; Department of Biomedical Engineering Johns Hopkins University School of Medicine Baltimore MD 21231 USA., Jain M; Department of Biomedical Engineering Johns Hopkins University School of Medicine Baltimore MD 21231 USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center Johns Hopkins University School of Medicine Baltimore MD 21231 USA., Idnani E; Translational ImmunoEngineering Center, Translational Tissue Engineering Center Johns Hopkins University School of Medicine Baltimore MD 21231 USA., Luly KM; Department of Biomedical Engineering Johns Hopkins University School of Medicine Baltimore MD 21231 USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center Johns Hopkins University School of Medicine Baltimore MD 21231 USA., Ruchika F; Department of Neurosurgery Johns Hopkins University School of Medicine Baltimore MD 21205 USA., Kraft C; Department of Neurosurgery Johns Hopkins University School of Medicine Baltimore MD 21205 USA., Eberhart C; Department of Pathology Johns Hopkins University School of Medicine Baltimore MD 21231 USA., Brem H; Department of Biomedical Engineering Johns Hopkins University School of Medicine Baltimore MD 21231 USA.; Department of Neurosurgery Johns Hopkins University School of Medicine Baltimore MD 21205 USA.; Department of Oncology and the Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University School of Medicine Baltimore MD 21231 USA.; Department of Ophthalmology Johns Hopkins University School of Medicine Baltimore MD 21231 USA., Tyler B; Department of Neurosurgery Johns Hopkins University School of Medicine Baltimore MD 21205 USA., Green JJ; Department of Biomedical Engineering Johns Hopkins University School of Medicine Baltimore MD 21231 USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center Johns Hopkins University School of Medicine Baltimore MD 21231 USA.; Department of Neurosurgery Johns Hopkins University School of Medicine Baltimore MD 21205 USA.; Department of Oncology and the Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University School of Medicine Baltimore MD 21231 USA.; Department of Ophthalmology Johns Hopkins University School of Medicine Baltimore MD 21231 USA.; Departments of Materials Science & Engineering and Chemical & Biomolecular Engineering Johns Hopkins University Baltimore MD 21218 USA.; Institute for NanoBioTechnology and the Bloomberg∼Kimmel Institute for Cancer Immunotherapy Johns Hopkins University Baltimore MD 21231 USA., Tzeng SY; Department of Biomedical Engineering Johns Hopkins University School of Medicine Baltimore MD 21231 USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center Johns Hopkins University School of Medicine Baltimore MD 21231 USA.
Source: Small science [Small Sci] 2026 Jan 05; Vol. 6 (1), pp. e202500475. Date of Electronic Publication: 2026 Jan 05 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Wiley-VCH GmbH Country of Publication: Germany NLM ID: 101777709 Publication Model: eCollection Cited Medium: Internet ISSN: 2688-4046 (Electronic) Linking ISSN: 26884046 NLM ISO Abbreviation: Small Sci Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: DNA-Loaded Nanoparticles Reprogram the Tumor Immune Microenvironment to Treat Brain Tumors.
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  Data: <searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Department of Biomedical Engineering Johns Hopkins University School of Medicine Baltimore MD 21231 USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center Johns Hopkins University School of Medicine Baltimore MD 21231 USA.<br /><searchLink fieldCode="AU" term="%22Raj+D%22">Raj D</searchLink>; Department of Neurosurgery Johns Hopkins University School of Medicine Baltimore MD 21205 USA.<br /><searchLink fieldCode="AU" term="%22Slika+H%22">Slika H</searchLink>; Department of Neurosurgery Johns Hopkins University School of Medicine Baltimore MD 21205 USA.<br /><searchLink fieldCode="AU" term="%22Shahani+A%22">Shahani A</searchLink>; Department of Neurosurgery Johns Hopkins University School of Medicine Baltimore MD 21205 USA.<br /><searchLink fieldCode="AU" term="%22Cheng+L%22">Cheng L</searchLink>; Translational ImmunoEngineering Center, Translational Tissue Engineering Center Johns Hopkins University School of Medicine Baltimore MD 21231 USA.; Department of Biomedical Engineering Johns Hopkins University School of Medicine Baltimore MD 21231 USA.<br /><searchLink fieldCode="AU" term="%22Jain+M%22">Jain M</searchLink>; Department of Biomedical Engineering Johns Hopkins University School of Medicine Baltimore MD 21231 USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center Johns Hopkins University School of Medicine Baltimore MD 21231 USA.<br /><searchLink fieldCode="AU" term="%22Idnani+E%22">Idnani E</searchLink>; Translational ImmunoEngineering Center, Translational Tissue Engineering Center Johns Hopkins University School of Medicine Baltimore MD 21231 USA.<br /><searchLink fieldCode="AU" term="%22Luly+KM%22">Luly KM</searchLink>; Department of Biomedical Engineering Johns Hopkins University School of Medicine Baltimore MD 21231 USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center Johns Hopkins University School of Medicine Baltimore MD 21231 USA.<br /><searchLink fieldCode="AU" term="%22Ruchika+F%22">Ruchika F</searchLink>; Department of Neurosurgery Johns Hopkins University School of Medicine Baltimore MD 21205 USA.<br /><searchLink fieldCode="AU" term="%22Kraft+C%22">Kraft C</searchLink>; Department of Neurosurgery Johns Hopkins University School of Medicine Baltimore MD 21205 USA.<br /><searchLink fieldCode="AU" term="%22Eberhart+C%22">Eberhart C</searchLink>; Department of Pathology Johns Hopkins University School of Medicine Baltimore MD 21231 USA.<br /><searchLink fieldCode="AU" term="%22Brem+H%22">Brem H</searchLink>; Department of Biomedical Engineering Johns Hopkins University School of Medicine Baltimore MD 21231 USA.; Department of Neurosurgery Johns Hopkins University School of Medicine Baltimore MD 21205 USA.; Department of Oncology and the Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University School of Medicine Baltimore MD 21231 USA.; Department of Ophthalmology Johns Hopkins University School of Medicine Baltimore MD 21231 USA.<br /><searchLink fieldCode="AU" term="%22Tyler+B%22">Tyler B</searchLink>; Department of Neurosurgery Johns Hopkins University School of Medicine Baltimore MD 21205 USA.<br /><searchLink fieldCode="AU" term="%22Green+JJ%22">Green JJ</searchLink>; Department of Biomedical Engineering Johns Hopkins University School of Medicine Baltimore MD 21231 USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center Johns Hopkins University School of Medicine Baltimore MD 21231 USA.; Department of Neurosurgery Johns Hopkins University School of Medicine Baltimore MD 21205 USA.; Department of Oncology and the Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University School of Medicine Baltimore MD 21231 USA.; Department of Ophthalmology Johns Hopkins University School of Medicine Baltimore MD 21231 USA.; Departments of Materials Science & Engineering and Chemical & Biomolecular Engineering Johns Hopkins University Baltimore MD 21218 USA.; Institute for NanoBioTechnology and the Bloomberg∼Kimmel Institute for Cancer Immunotherapy Johns Hopkins University Baltimore MD 21231 USA.<br /><searchLink fieldCode="AU" term="%22Tzeng+SY%22">Tzeng SY</searchLink>; Department of Biomedical Engineering Johns Hopkins University School of Medicine Baltimore MD 21231 USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center Johns Hopkins University School of Medicine Baltimore MD 21231 USA.
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