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Defective DNA Damage Response Is a Targetable Therapeutic Vulnerability in ESR1-Mutant Breast Cancer.

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Title: Defective DNA Damage Response Is a Targetable Therapeutic Vulnerability in ESR1-Mutant Breast Cancer.
Authors: Herzog SK; Integrative Molecular and Biomedical Sciences Program, Baylor College of Medicine, Houston, Texas.; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas., Stevens JH; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas., Gu G; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas., Grimm SL; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas., Cardoza K; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas., Hawkins AGM; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.; Cancer and Cell Biology Program, Baylor College of Medicine, Houston, Texas., Lin H; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas., Ramos D; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas., Beyer AR; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas., Edwards DG; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas., Dustin D; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.; Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas., Yang HJ; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas., Liang N; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas., Khan AF; Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas., Bawa-Khalfe T; Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas., McGrail DJ; Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio., Lin SY; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Coarfa C; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas., Fuqua SAW; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
Source: Cancer research [Cancer Res] 2026 Apr 02; Vol. 86 (7), pp. 1707-1723.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Herzog+SK%22">Herzog SK</searchLink>; Integrative Molecular and Biomedical Sciences Program, Baylor College of Medicine, Houston, Texas.; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Stevens+JH%22">Stevens JH</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Gu+G%22">Gu G</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Grimm+SL%22">Grimm SL</searchLink>; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Cardoza+K%22">Cardoza K</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Hawkins+AGM%22">Hawkins AGM</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.; Cancer and Cell Biology Program, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Lin+H%22">Lin H</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Ramos+D%22">Ramos D</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Beyer+AR%22">Beyer AR</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Edwards+DG%22">Edwards DG</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Dustin+D%22">Dustin D</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.; Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Yang+HJ%22">Yang HJ</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Liang+N%22">Liang N</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Khan+AF%22">Khan AF</searchLink>; Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Bawa-Khalfe+T%22">Bawa-Khalfe T</searchLink>; Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22McGrail+DJ%22">McGrail DJ</searchLink>; Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio.<br /><searchLink fieldCode="AU" term="%22Lin+SY%22">Lin SY</searchLink>; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Coarfa+C%22">Coarfa C</searchLink>; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Fuqua+SAW%22">Fuqua SAW</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
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