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Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3.

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Title: Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3.
Authors: Hennes E; Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany.; Technische Universität Dortmund, Fakultät Chemie und Chemische Biologie, Dortmund, Germany., Lucas B; Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany., Scholes NS; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Cheng XF; Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany., Scott DC; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Bischoff M; Compound Management and Screening Center Otto-Hahn-Str.11, Dortmund, Germany., Reich K; Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany., Gasper R; Max-Planck-Institut für Molekulare Physiologie, Zentrale Einheit für Kristallographie und Biophysik, Dortmund, Germany., Lucas M; Instituto de Biomedicina y Biotecnología de Cantabria, Universidad de Cantabria-CSIC, Santander, Spain., Xu TT; Immunoregulation Research Group, Max Planck Institute of Biochemistry, Martinsried, Germany., Rossini S; Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Pulvermacher LM; Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany., Dötsch L; Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany.; Technische Universität Dortmund, Fakultät Chemie und Chemische Biologie, Dortmund, Germany., Imrichova H; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Brause A; Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany., Führer S; Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany.; Chemical Genomics Centre, Max-Planck-Institut für Molekulare Physiologie, Dortmund, Germany., Naredla KR; Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany., Sievers S; Compound Management and Screening Center Otto-Hahn-Str.11, Dortmund, Germany., Kumar K; Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany., Janning P; Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany., Orabona C; Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Gersch M; Technische Universität Dortmund, Fakultät Chemie und Chemische Biologie, Dortmund, Germany.; Chemical Genomics Centre, Max-Planck-Institut für Molekulare Physiologie, Dortmund, Germany., Murray PJ; Immunoregulation Research Group, Max Planck Institute of Biochemistry, Martinsried, Germany., Schulman BA; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany., Winter GE; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. gwinter@aithyra.at.; AITHYRA Research Institute for Biomedical AI, Vienna, Austria. gwinter@aithyra.at., Ziegler S; Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany., Waldmann H; Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany. herbert.waldmann@mpi-dortmund.mpg.de.; Technische Universität Dortmund, Fakultät Chemie und Chemische Biologie, Dortmund, Germany. herbert.waldmann@mpi-dortmund.mpg.de.
Source: Nature chemistry [Nat Chem] 2026 Mar; Vol. 18 (3), pp. 585-596. Date of Electronic Publication: 2026 Jan 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101499734 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1755-4349 (Electronic) Linking ISSN: 17554330 NLM ISO Abbreviation: Nat Chem Subsets: MEDLINE
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  Data: Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3.
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  Data: <searchLink fieldCode="AU" term="%22Hennes+E%22">Hennes E</searchLink>; Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany.; Technische Universität Dortmund, Fakultät Chemie und Chemische Biologie, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Lucas+B%22">Lucas B</searchLink>; Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Scholes+NS%22">Scholes NS</searchLink>; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Cheng+XF%22">Cheng XF</searchLink>; Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Scott+DC%22">Scott DC</searchLink>; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Bischoff+M%22">Bischoff M</searchLink>; Compound Management and Screening Center Otto-Hahn-Str.11, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Reich+K%22">Reich K</searchLink>; Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Gasper+R%22">Gasper R</searchLink>; Max-Planck-Institut für Molekulare Physiologie, Zentrale Einheit für Kristallographie und Biophysik, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Lucas+M%22">Lucas M</searchLink>; Instituto de Biomedicina y Biotecnología de Cantabria, Universidad de Cantabria-CSIC, Santander, Spain.<br /><searchLink fieldCode="AU" term="%22Xu+TT%22">Xu TT</searchLink>; Immunoregulation Research Group, Max Planck Institute of Biochemistry, Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Rossini+S%22">Rossini S</searchLink>; Department of Medicine and Surgery, University of Perugia, Perugia, Italy.<br /><searchLink fieldCode="AU" term="%22Pulvermacher+LM%22">Pulvermacher LM</searchLink>; Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Dötsch+L%22">Dötsch L</searchLink>; Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany.; Technische Universität Dortmund, Fakultät Chemie und Chemische Biologie, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Imrichova+H%22">Imrichova H</searchLink>; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Brause+A%22">Brause A</searchLink>; Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Führer+S%22">Führer S</searchLink>; Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany.; Chemical Genomics Centre, Max-Planck-Institut für Molekulare Physiologie, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Naredla+KR%22">Naredla KR</searchLink>; Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Sievers+S%22">Sievers S</searchLink>; Compound Management and Screening Center Otto-Hahn-Str.11, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Kumar+K%22">Kumar K</searchLink>; Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Janning+P%22">Janning P</searchLink>; Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Orabona+C%22">Orabona C</searchLink>; Department of Medicine and Surgery, University of Perugia, Perugia, Italy.<br /><searchLink fieldCode="AU" term="%22Gersch+M%22">Gersch M</searchLink>; Technische Universität Dortmund, Fakultät Chemie und Chemische Biologie, Dortmund, Germany.; Chemical Genomics Centre, Max-Planck-Institut für Molekulare Physiologie, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Murray+PJ%22">Murray PJ</searchLink>; Immunoregulation Research Group, Max Planck Institute of Biochemistry, Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Schulman+BA%22">Schulman BA</searchLink>; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Winter+GE%22">Winter GE</searchLink>; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. gwinter@aithyra.at.; AITHYRA Research Institute for Biomedical AI, Vienna, Austria. gwinter@aithyra.at.<br /><searchLink fieldCode="AU" term="%22Ziegler+S%22">Ziegler S</searchLink>; Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Waldmann+H%22">Waldmann H</searchLink>; Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany. herbert.waldmann@mpi-dortmund.mpg.de.; Technische Universität Dortmund, Fakultät Chemie und Chemische Biologie, Dortmund, Germany. herbert.waldmann@mpi-dortmund.mpg.de.
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  Data: <searchLink fieldCode="JN" term="%22101499734%22">Nature chemistry</searchLink> [Nat Chem] 2026 Mar; Vol. 18 (3), pp. 585-596. <i>Date of Electronic Publication: </i>2026 Jan 07.
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