Stress Hydrocortisone in Pediatric Septic Shock: Protocol for a Pragmatic, Multicenter, International, Randomized, Double-Blinded, Placebo-Controlled Interventional Trial.
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| Title: | Stress Hydrocortisone in Pediatric Septic Shock: Protocol for a Pragmatic, Multicenter, International, Randomized, Double-Blinded, Placebo-Controlled Interventional Trial. |
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| Authors: | Menon K; Department of Pediatrics, Children's Hospital of Eastern Ontario, ON, Canada.; Children's Hospital of Eastern Ontario Research Institute, ON, Canada., Agus MSD; Department of Pediatrics, Harvard Medical School, Boston, MA.; Division of Medical Critical Care, Department of Pediatrics, Boston Children's Hospital, Boston, MA., O'Hearn K; Children's Hospital of Eastern Ontario Research Institute, ON, Canada., Coughlin-Wells K; Division of Medical Critical Care, Department of Pediatrics, Boston Children's Hospital, Boston, MA., Choong K; Department of Pediatrics, Division of Critical Care, McMaster University, Hamilton, ON, Canada.; Department of Health Research Methods and Impact, McMaster University, Hamilton, ON, Canada., Kazzaz Y; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.; Department of Pediatrics, Ministry of the National Guard Health-Affairs, Riyadh, Saudi Arabia., Lee JH; Children's Intensive Care Unit, KK Women's and Children's Hospital, Singapore, Singapore.; SingHealth Duke-NUS Paediatrics Academic Clinical Programme, Duke-NUS Medical School, Singapore, Singapore., McNally D; Department of Pediatrics, Children's Hospital of Eastern Ontario, ON, Canada.; Children's Hospital of Eastern Ontario Research Institute, ON, Canada., Atreya MR; Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.; Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH., Ramsay T; Ottawa Hospital Research Institute, Ottawa, ON, Canada., Watson RS; Department of Pediatrics, Seattle Children's Research Institute, University of Washington School of Medicine, Seattle, WA., Wypij D; Department of Pediatrics, Harvard Medical School, Boston, MA.; Department of Biostatistics, Harvard School of Public Health, Boston, MA.; Department of Cardiology, Boston Children's Hospital, Boston, MA., Zimmerman JJ; Department of Pediatrics, Seattle Children's Research Institute, University of Washington School of Medicine, Seattle, WA. |
| Corporate Authors: | Stress Hydrocortisone in Pediatric Septic Shock (SHIPSS) Study Investigators, Canadian Critical Care Trials Group, and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network |
| Source: | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies [Pediatr Crit Care Med] 2026 Jan 01; Vol. 27 (1), pp. 102-113. Date of Electronic Publication: 2025 Nov 26. |
| Publication Type: | Journal Article; Clinical Trial Protocol |
| Journal Info: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 100954653 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-7535 (Print) Linking ISSN: 15297535 NLM ISO Abbreviation: Pediatr Crit Care Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41504575 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Stress Hydrocortisone in Pediatric Septic Shock: Protocol for a Pragmatic, Multicenter, International, Randomized, Double-Blinded, Placebo-Controlled Interventional Trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Menon+K%22">Menon K</searchLink>; Department of Pediatrics, Children's Hospital of Eastern Ontario, ON, Canada.; Children's Hospital of Eastern Ontario Research Institute, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Agus+MSD%22">Agus MSD</searchLink>; Department of Pediatrics, Harvard Medical School, Boston, MA.; Division of Medical Critical Care, Department of Pediatrics, Boston Children's Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22O'Hearn+K%22">O'Hearn K</searchLink>; Children's Hospital of Eastern Ontario Research Institute, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Coughlin-Wells+K%22">Coughlin-Wells K</searchLink>; Division of Medical Critical Care, Department of Pediatrics, Boston Children's Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Choong+K%22">Choong K</searchLink>; Department of Pediatrics, Division of Critical Care, McMaster University, Hamilton, ON, Canada.; Department of Health Research Methods and Impact, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Kazzaz+Y%22">Kazzaz Y</searchLink>; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.; Department of Pediatrics, Ministry of the National Guard Health-Affairs, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Lee+JH%22">Lee JH</searchLink>; Children's Intensive Care Unit, KK Women's and Children's Hospital, Singapore, Singapore.; SingHealth Duke-NUS Paediatrics Academic Clinical Programme, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22McNally+D%22">McNally D</searchLink>; Department of Pediatrics, Children's Hospital of Eastern Ontario, ON, Canada.; Children's Hospital of Eastern Ontario Research Institute, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Atreya+MR%22">Atreya MR</searchLink>; Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.; Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH.<br /><searchLink fieldCode="AU" term="%22Ramsay+T%22">Ramsay T</searchLink>; Ottawa Hospital Research Institute, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Watson+RS%22">Watson RS</searchLink>; Department of Pediatrics, Seattle Children's Research Institute, University of Washington School of Medicine, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Wypij+D%22">Wypij D</searchLink>; Department of Pediatrics, Harvard Medical School, Boston, MA.; Department of Biostatistics, Harvard School of Public Health, Boston, MA.; Department of Cardiology, Boston Children's Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Zimmerman+JJ%22">Zimmerman JJ</searchLink>; Department of Pediatrics, Seattle Children's Research Institute, University of Washington School of Medicine, Seattle, WA. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22Stress+Hydrocortisone+in+Pediatric+Septic+Shock+%28SHIPSS%29+Study+Investigators%2C+Canadian+Critical+Care+Trials+Group%2C+and+the+Pediatric+Acute+Lung+Injury+and+Sepsis+Investigators+%28PALISI%29+Network%22">Stress Hydrocortisone in Pediatric Septic Shock (SHIPSS) Study Investigators, Canadian Critical Care Trials Group, and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22100954653%22">Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies</searchLink> [Pediatr Crit Care Med] 2026 Jan 01; Vol. 27 (1), pp. 102-113. <i>Date of Electronic Publication: </i>2025 Nov 26. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial Protocol – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lippincott+Williams+%26+Wilkins%22">Lippincott Williams & Wilkins </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100954653 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1529-7535 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215297535%22">15297535 </searchLink><i>NLM ISO Abbreviation: </i>Pediatr Crit Care Med <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41504575 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1097/PCC.0000000000003872 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 102 Titles: – TitleFull: Stress Hydrocortisone in Pediatric Septic Shock: Protocol for a Pragmatic, Multicenter, International, Randomized, Double-Blinded, Placebo-Controlled Interventional Trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Menon K – PersonEntity: Name: NameFull: Agus MSD – PersonEntity: Name: NameFull: O'Hearn K – PersonEntity: Name: NameFull: Coughlin-Wells K – PersonEntity: Name: NameFull: Choong K – PersonEntity: Name: NameFull: Kazzaz Y – PersonEntity: Name: NameFull: Lee JH – PersonEntity: Name: NameFull: McNally D – PersonEntity: Name: NameFull: Atreya MR – PersonEntity: Name: NameFull: Ramsay T – PersonEntity: Name: NameFull: Watson RS – PersonEntity: Name: NameFull: Wypij D – PersonEntity: Name: NameFull: Zimmerman JJ IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: 2026 Jan 01 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 1529-7535 Numbering: – Type: volume Value: 27 – Type: issue Value: 1 Titles: – TitleFull: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies Type: main |
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