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Acetaminophen (Paracetamol) or Opioid Analgesia Added to Ibuprofen for Children's Musculoskeletal Injury: Two Randomized Clinical Trials.

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Title: Acetaminophen (Paracetamol) or Opioid Analgesia Added to Ibuprofen for Children's Musculoskeletal Injury: Two Randomized Clinical Trials.
Authors: Ali S; Department of Pediatrics, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada.; Women and Children's Health Research Institute, University of Alberta, Edmonton, Alberta, Canada., Klassen TP; Department of Pediatrics, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.; Jim Pattison Children's Hospital, Saskatoon, Saskatchewan, Canada., Candelaria P; Department of Pediatrics, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada., Bhatt M; Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada.; Emergency Medicine, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada., Sawyer S; Departments of Pediatrics and Emergency Medicine, HSC Winnipeg Children's Hospital, Winnipeg, Manitoba, Canada.; Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada., Stang A; Department of Pediatrics, Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada.; Alberta Children's Hospital Research Institute, Calgary, Alberta, Canada., Yaskina M; Women and Children's Health Research Institute, University of Alberta, Edmonton, Alberta, Canada., Heath A; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.; Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Statistical Science, University College London, London, United Kingdom., Pechlivanoglou P; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.; Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada., Offringa M; Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada., Drendel AL; Department of Pediatrics, Medical College of Wisconsin, Milwaukee., Hickes S; Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada., Poonai N; Departments of Pediatrics and Epidemiology & Biostatistics, Western University, London, Ontario, Canada.
Corporate Authors: KidsCAN PERC Innovative Pediatric Clinical Trials No OUCH Study Team
Source: JAMA [JAMA] 2026 Mar 10; Vol. 335 (10), pp. 863-873.
Publication Type: Clinical Trial, Phase II; Equivalence Trial; Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Acetaminophen (Paracetamol) or Opioid Analgesia Added to Ibuprofen for Children's Musculoskeletal Injury: Two Randomized Clinical Trials.
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        Value: 10.1001/jama.2025.25033
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              Text: 2026 Mar 10
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