View in EDS

TIGIT disruption rescues the antitumor activity of low avidity TCR-engineered T cells by increasing TCR signal strength.

Saved in:
Bibliographic Details
Title: TIGIT disruption rescues the antitumor activity of low avidity TCR-engineered T cells by increasing TCR signal strength.
Authors: Spiga M; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Potenza A; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Magnani Z; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Beretta S; San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), IRCSS San Raffaele Scientific Institute, Milan, Italy., Camisa B; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Conte L; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Airaghi A; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Mohammadi N; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Perani L; Preclinical Imaging, Experimental Imaging Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy., Doglioni C; Pathology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Ponzoni M; Pathology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Sanvito F; Pathology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Balestrieri C; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, Milan, Italy., Sergi Sergi L; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Botrugno OA; Vita-Salute San Raffaele University, Milan, Italy.; Functional Genomics of Cancer Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Giovannoni G; Functional Genomics of Cancer Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Tonon G; Vita-Salute San Raffaele University, Milan, Italy.; Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Functional Genomics of Cancer Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Abbati D; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Iozzi C; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Reichert M; Translational Pancreatic Cancer Research Center, Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technische Universität München, Munich, Germany., Algul H; Department of Gastroenterology, Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich (TUM), Munich, Germany., Pocaterra A; Lymphocyte activation Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Fiumara M; San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), IRCSS San Raffaele Scientific Institute, Milan, Italy., Ferrari S; San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), IRCSS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Ugolini A; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Grometto A; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Di Lullo G; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Sitia G; Vita-Salute San Raffaele University, Milan, Italy.; Experimental hepatology, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Belfiori G; Pancreatic Surgery and Transplantation Unit, Pancreas Translational and Clinical Research Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy., Protti MP; Tumor immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Ostuni R; San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), IRCSS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Mondino A; Lymphocyte activation Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Reni M; Vita-Salute San Raffaele University, Milan, Italy.; Medical Oncology Unit, Pancreas Translational and Clinical Research Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy., Crippa S; Vita-Salute San Raffaele University, Milan, Italy.; Pancreatic Surgery and Transplantation Unit, Pancreas Translational and Clinical Research Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy., Falconi M; Vita-Salute San Raffaele University, Milan, Italy.; Pancreatic Surgery and Transplantation Unit, Pancreas Translational and Clinical Research Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy., Naldini L; San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), IRCSS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Ruggiero E; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Bonini C; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy. bonini.chiara@hsr.it.; Vita-Salute San Raffaele University, Milan, Italy. bonini.chiara@hsr.it.
Source: Nature communications [Nat Commun] 2026 Jan 08; Vol. 17 (1), pp. 568. Date of Electronic Publication: 2026 Jan 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41507193
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: TIGIT disruption rescues the antitumor activity of low avidity TCR-engineered T cells by increasing TCR signal strength.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Spiga+M%22">Spiga M</searchLink>; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Potenza+A%22">Potenza A</searchLink>; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Magnani+Z%22">Magnani Z</searchLink>; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Beretta+S%22">Beretta S</searchLink>; San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), IRCSS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Camisa+B%22">Camisa B</searchLink>; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Conte+L%22">Conte L</searchLink>; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Airaghi+A%22">Airaghi A</searchLink>; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Mohammadi+N%22">Mohammadi N</searchLink>; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Perani+L%22">Perani L</searchLink>; Preclinical Imaging, Experimental Imaging Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Doglioni+C%22">Doglioni C</searchLink>; Pathology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ponzoni+M%22">Ponzoni M</searchLink>; Pathology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Sanvito+F%22">Sanvito F</searchLink>; Pathology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Balestrieri+C%22">Balestrieri C</searchLink>; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Sergi+Sergi+L%22">Sergi Sergi L</searchLink>; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Botrugno+OA%22">Botrugno OA</searchLink>; Vita-Salute San Raffaele University, Milan, Italy.; Functional Genomics of Cancer Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Giovannoni+G%22">Giovannoni G</searchLink>; Functional Genomics of Cancer Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Tonon+G%22">Tonon G</searchLink>; Vita-Salute San Raffaele University, Milan, Italy.; Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Functional Genomics of Cancer Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Abbati+D%22">Abbati D</searchLink>; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Iozzi+C%22">Iozzi C</searchLink>; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Reichert+M%22">Reichert M</searchLink>; Translational Pancreatic Cancer Research Center, Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Algul+H%22">Algul H</searchLink>; Department of Gastroenterology, Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich (TUM), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Pocaterra+A%22">Pocaterra A</searchLink>; Lymphocyte activation Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Fiumara+M%22">Fiumara M</searchLink>; San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), IRCSS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ferrari+S%22">Ferrari S</searchLink>; San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), IRCSS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ugolini+A%22">Ugolini A</searchLink>; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Grometto+A%22">Grometto A</searchLink>; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Lullo+G%22">Di Lullo G</searchLink>; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Sitia+G%22">Sitia G</searchLink>; Vita-Salute San Raffaele University, Milan, Italy.; Experimental hepatology, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Belfiori+G%22">Belfiori G</searchLink>; Pancreatic Surgery and Transplantation Unit, Pancreas Translational and Clinical Research Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Protti+MP%22">Protti MP</searchLink>; Tumor immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ostuni+R%22">Ostuni R</searchLink>; San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), IRCSS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Mondino+A%22">Mondino A</searchLink>; Lymphocyte activation Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Reni+M%22">Reni M</searchLink>; Vita-Salute San Raffaele University, Milan, Italy.; Medical Oncology Unit, Pancreas Translational and Clinical Research Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Crippa+S%22">Crippa S</searchLink>; Vita-Salute San Raffaele University, Milan, Italy.; Pancreatic Surgery and Transplantation Unit, Pancreas Translational and Clinical Research Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Falconi+M%22">Falconi M</searchLink>; Vita-Salute San Raffaele University, Milan, Italy.; Pancreatic Surgery and Transplantation Unit, Pancreas Translational and Clinical Research Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Naldini+L%22">Naldini L</searchLink>; San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), IRCSS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ruggiero+E%22">Ruggiero E</searchLink>; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bonini+C%22">Bonini C</searchLink>; Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy. bonini.chiara@hsr.it.; Vita-Salute San Raffaele University, Milan, Italy. bonini.chiara@hsr.it.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Jan 08; Vol. 17 (1), pp. 568. <i>Date of Electronic Publication: </i>2026 Jan 08.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41507193
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41467-025-67263-w
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 568
    Titles:
      – TitleFull: TIGIT disruption rescues the antitumor activity of low avidity TCR-engineered T cells by increasing TCR signal strength.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Spiga M
      – PersonEntity:
          Name:
            NameFull: Potenza A
      – PersonEntity:
          Name:
            NameFull: Magnani Z
      – PersonEntity:
          Name:
            NameFull: Beretta S
      – PersonEntity:
          Name:
            NameFull: Camisa B
      – PersonEntity:
          Name:
            NameFull: Conte L
      – PersonEntity:
          Name:
            NameFull: Airaghi A
      – PersonEntity:
          Name:
            NameFull: Mohammadi N
      – PersonEntity:
          Name:
            NameFull: Perani L
      – PersonEntity:
          Name:
            NameFull: Doglioni C
      – PersonEntity:
          Name:
            NameFull: Ponzoni M
      – PersonEntity:
          Name:
            NameFull: Sanvito F
      – PersonEntity:
          Name:
            NameFull: Balestrieri C
      – PersonEntity:
          Name:
            NameFull: Sergi Sergi L
      – PersonEntity:
          Name:
            NameFull: Botrugno OA
      – PersonEntity:
          Name:
            NameFull: Giovannoni G
      – PersonEntity:
          Name:
            NameFull: Tonon G
      – PersonEntity:
          Name:
            NameFull: Abbati D
      – PersonEntity:
          Name:
            NameFull: Iozzi C
      – PersonEntity:
          Name:
            NameFull: Reichert M
      – PersonEntity:
          Name:
            NameFull: Algul H
      – PersonEntity:
          Name:
            NameFull: Pocaterra A
      – PersonEntity:
          Name:
            NameFull: Fiumara M
      – PersonEntity:
          Name:
            NameFull: Ferrari S
      – PersonEntity:
          Name:
            NameFull: Ugolini A
      – PersonEntity:
          Name:
            NameFull: Grometto A
      – PersonEntity:
          Name:
            NameFull: Di Lullo G
      – PersonEntity:
          Name:
            NameFull: Sitia G
      – PersonEntity:
          Name:
            NameFull: Belfiori G
      – PersonEntity:
          Name:
            NameFull: Protti MP
      – PersonEntity:
          Name:
            NameFull: Ostuni R
      – PersonEntity:
          Name:
            NameFull: Mondino A
      – PersonEntity:
          Name:
            NameFull: Reni M
      – PersonEntity:
          Name:
            NameFull: Crippa S
      – PersonEntity:
          Name:
            NameFull: Falconi M
      – PersonEntity:
          Name:
            NameFull: Naldini L
      – PersonEntity:
          Name:
            NameFull: Ruggiero E
      – PersonEntity:
          Name:
            NameFull: Bonini C
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 08
              M: 01
              Text: 2026 Jan 08
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 17
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1