Neuron-specific WDR5 epigenetically upregulates ARID5B to impair GABAergic synaptic transmission and promotes epileptogenesis.
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| Title: | Neuron-specific WDR5 epigenetically upregulates ARID5B to impair GABAergic synaptic transmission and promotes epileptogenesis. |
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| Authors: | Gu J; Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical, Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China.; Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.; Department of Anesthesiology, First Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China., Ke PY; Department of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Neurology Key Laboratory of Chongqing Education Commission of China, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China., Zhang XY; Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical, Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China., Liu C; Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical, Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China., Yang Y; Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical, Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China., Yu ML; Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical, Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China., Xu ZZ; Department of Anesthesiology, First Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China., Zhang CX; Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical, Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China., Dong W; Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical, Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China. |
| Source: | Theranostics [Theranostics] 2026 Jan 01; Vol. 16 (6), pp. 2721-2747. Date of Electronic Publication: 2026 Jan 01 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101552395 Publication Model: eCollection Cited Medium: Internet ISSN: 1838-7640 (Electronic) Linking ISSN: 18387640 NLM ISO Abbreviation: Theranostics Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41510154 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Neuron-specific WDR5 epigenetically upregulates ARID5B to impair GABAergic synaptic transmission and promotes epileptogenesis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Gu+J%22">Gu J</searchLink>; Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical, Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China.; Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.; Department of Anesthesiology, First Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Ke+PY%22">Ke PY</searchLink>; Department of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Neurology Key Laboratory of Chongqing Education Commission of China, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Zhang+XY%22">Zhang XY</searchLink>; Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical, Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical, Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical, Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China.<br /><searchLink fieldCode="AU" term="%22Yu+ML%22">Yu ML</searchLink>; Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical, Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China.<br /><searchLink fieldCode="AU" term="%22Xu+ZZ%22">Xu ZZ</searchLink>; Department of Anesthesiology, First Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Zhang+CX%22">Zhang CX</searchLink>; Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical, Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China.<br /><searchLink fieldCode="AU" term="%22Dong+W%22">Dong W</searchLink>; Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical, Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101552395%22">Theranostics</searchLink> [Theranostics] 2026 Jan 01; Vol. 16 (6), pp. 2721-2747. <i>Date of Electronic Publication: </i>2026 Jan 01 (<i>Print Publication: </i>2026). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Ivyspring+International+Publisher%22">Ivyspring International Publisher </searchLink><i>Country of Publication: </i>Australia <i>NLM ID: </i>101552395 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1838-7640 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2218387640%22">18387640 </searchLink><i>NLM ISO Abbreviation: </i>Theranostics <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41510154 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.7150/thno.122246 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 2721 Titles: – TitleFull: Neuron-specific WDR5 epigenetically upregulates ARID5B to impair GABAergic synaptic transmission and promotes epileptogenesis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Gu J – PersonEntity: Name: NameFull: Ke PY – PersonEntity: Name: NameFull: Zhang XY – PersonEntity: Name: NameFull: Liu C – PersonEntity: Name: NameFull: Yang Y – PersonEntity: Name: NameFull: Yu ML – PersonEntity: Name: NameFull: Xu ZZ – PersonEntity: Name: NameFull: Zhang CX – PersonEntity: Name: NameFull: Dong W IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: 2026 Jan 01 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1838-7640 Numbering: – Type: volume Value: 16 – Type: issue Value: 6 Titles: – TitleFull: Theranostics Type: main |
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