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Diabetes does not modify the renal-protective effect of intravenous amino acids infusion after cardiac surgery.

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Title: Diabetes does not modify the renal-protective effect of intravenous amino acids infusion after cardiac surgery.
Authors: Consonni M; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Fresilli S; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Kotani Y; Department of Intensive Care Medicine, Kameda Medical Center, Kamogawa, Japan., Garofalo E; Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy., Bradic N; Clinic of Anesthesiology, Resuscitation and Intensive Care, University Hospital Dubrava, Zagreb, Croatia.; Department of Nursing, University North, Varazdin, Croatia., Scandroglio AM; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Ti LK; Department of Anaesthesia, National University Hospital, Lower Kent Ridge Road, Singapore., Comis M; S.C. Anestesia e Rianimazione Cardiovascolare, A.O.Ordine Mauriziano, Umberto I di Torino, Turin, Italy., Oriani A; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Pisano A; Cardiac Anesthesia and ICU, AORN 'Dei Colli', Monaldi Hospital, Naples, Italy., Belletti A; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Guarracino F; Department of Cardiothoracic Anaesthesia and IC, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy., Losiggio R; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy. losiggio.rosario@hsr.it.; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, Milan, 20132, Italy. losiggio.rosario@hsr.it., Redaelli MB; General and Neurosurgical Intensive Care Units, ASST Sette Laghi, Ospedale Di Circolo, Varese, Italy.; Department of Biotechnologies and Life Sciences, University of Insubria, Varese, Italy., Pontillo D; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Arangino C; Department of Cardiothoracic Anesthesia and Intensive Care, IRCCS Centro Cardiologico Monzino, Milan, Italy., Pruna A; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Federici F; UOC Anestesia e Rianimazione, Azienda Ospedaliero-Universitaria Sant'Andrea, Rome, Italy., D'Amico F; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Silvetti S; Department of Cardiac Anesthesia and Intensive Care, Ospedale Policlinico San Martino IRCCS, IRCCS Cardiovascular Network, Genova, Italy., Labanca R; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Ferrod F; S.C. Anestesia e Rianimazione Cardiovascolare, A.O.Ordine Mauriziano, Umberto I di Torino, Turin, Italy., Pittella G; Cardiovascular Anaesthesia and ICU, San Carlo Hospital, Potenza, Italy., Corbo F; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Ranucci M; Department of Cardiovascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, San Donato Milanese, Italy., Cortegiani A; Department of Precision Medicine in Medical, Surgical and Critical Care Area (Me.Pre.C.C.), University of Palermo, Palermo, Italy.; Department of Anesthesia, Intensive Care and Emergency, University Hospital Policlinico Paolo Giaccone, Analgesia, Palermo, Italy., Paternoster G; Department of Health Sciences, University of Basilicata, Potenza, Italy.; Anesthesia and ICU, San Carlo Hospital, Potenza, Italy., Bove T; Department of Basic Biotechnological Sciences, Intensive Care Peri- Operative Clinics, Università Cattolica del Sacro Cuore, Rome, Italy.; Department of Emergency, Anesthesiological and Reanimation Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Longhini F; Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy., Monaco F; Departement. of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum - University of Bologna, Bologna, Italy.; Cardiothoracic and Vascular Anesthesia and Intensive Care, IRCCS Azienda Ospedaliero-Universitaria Sant'Orsola, Bologna, Italy., Zangrillo A; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy., Piemonti L; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.; Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Corporate Authors: PROTECTION Study Group Collaborators
Source: Journal of endocrinological investigation [J Endocrinol Invest] 2026 May; Vol. 49 (5), pp. 1163-1172. Date of Electronic Publication: 2026 Jan 09.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Springer Country of Publication: Italy NLM ID: 7806594 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1720-8386 (Electronic) Linking ISSN: 03914097 NLM ISO Abbreviation: J Endocrinol Invest Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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  Data: Diabetes does not modify the renal-protective effect of intravenous amino acids infusion after cardiac surgery.
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  Data: <searchLink fieldCode="AU" term="%22Consonni+M%22">Consonni M</searchLink>; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Fresilli+S%22">Fresilli S</searchLink>; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Kotani+Y%22">Kotani Y</searchLink>; Department of Intensive Care Medicine, Kameda Medical Center, Kamogawa, Japan.<br /><searchLink fieldCode="AU" term="%22Garofalo+E%22">Garofalo E</searchLink>; Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.<br /><searchLink fieldCode="AU" term="%22Bradic+N%22">Bradic N</searchLink>; Clinic of Anesthesiology, Resuscitation and Intensive Care, University Hospital Dubrava, Zagreb, Croatia.; Department of Nursing, University North, Varazdin, Croatia.<br /><searchLink fieldCode="AU" term="%22Scandroglio+AM%22">Scandroglio AM</searchLink>; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ti+LK%22">Ti LK</searchLink>; Department of Anaesthesia, National University Hospital, Lower Kent Ridge Road, Singapore.<br /><searchLink fieldCode="AU" term="%22Comis+M%22">Comis M</searchLink>; S.C. Anestesia e Rianimazione Cardiovascolare, A.O.Ordine Mauriziano, Umberto I di Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Oriani+A%22">Oriani A</searchLink>; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pisano+A%22">Pisano A</searchLink>; Cardiac Anesthesia and ICU, AORN 'Dei Colli', Monaldi Hospital, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Belletti+A%22">Belletti A</searchLink>; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Guarracino+F%22">Guarracino F</searchLink>; Department of Cardiothoracic Anaesthesia and IC, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Losiggio+R%22">Losiggio R</searchLink>; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy. losiggio.rosario@hsr.it.; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, Milan, 20132, Italy. losiggio.rosario@hsr.it.<br /><searchLink fieldCode="AU" term="%22Redaelli+MB%22">Redaelli MB</searchLink>; General and Neurosurgical Intensive Care Units, ASST Sette Laghi, Ospedale Di Circolo, Varese, Italy.; Department of Biotechnologies and Life Sciences, University of Insubria, Varese, Italy.<br /><searchLink fieldCode="AU" term="%22Pontillo+D%22">Pontillo D</searchLink>; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Arangino+C%22">Arangino C</searchLink>; Department of Cardiothoracic Anesthesia and Intensive Care, IRCCS Centro Cardiologico Monzino, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pruna+A%22">Pruna A</searchLink>; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Federici+F%22">Federici F</searchLink>; UOC Anestesia e Rianimazione, Azienda Ospedaliero-Universitaria Sant'Andrea, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22D'Amico+F%22">D'Amico F</searchLink>; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Silvetti+S%22">Silvetti S</searchLink>; Department of Cardiac Anesthesia and Intensive Care, Ospedale Policlinico San Martino IRCCS, IRCCS Cardiovascular Network, Genova, Italy.<br /><searchLink fieldCode="AU" term="%22Labanca+R%22">Labanca R</searchLink>; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ferrod+F%22">Ferrod F</searchLink>; S.C. Anestesia e Rianimazione Cardiovascolare, A.O.Ordine Mauriziano, Umberto I di Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Pittella+G%22">Pittella G</searchLink>; Cardiovascular Anaesthesia and ICU, San Carlo Hospital, Potenza, Italy.<br /><searchLink fieldCode="AU" term="%22Corbo+F%22">Corbo F</searchLink>; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ranucci+M%22">Ranucci M</searchLink>; Department of Cardiovascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, San Donato Milanese, Italy.<br /><searchLink fieldCode="AU" term="%22Cortegiani+A%22">Cortegiani A</searchLink>; Department of Precision Medicine in Medical, Surgical and Critical Care Area (Me.Pre.C.C.), University of Palermo, Palermo, Italy.; Department of Anesthesia, Intensive Care and Emergency, University Hospital Policlinico Paolo Giaccone, Analgesia, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Paternoster+G%22">Paternoster G</searchLink>; Department of Health Sciences, University of Basilicata, Potenza, Italy.; Anesthesia and ICU, San Carlo Hospital, Potenza, Italy.<br /><searchLink fieldCode="AU" term="%22Bove+T%22">Bove T</searchLink>; Department of Basic Biotechnological Sciences, Intensive Care Peri- Operative Clinics, Università Cattolica del Sacro Cuore, Rome, Italy.; Department of Emergency, Anesthesiological and Reanimation Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Longhini+F%22">Longhini F</searchLink>; Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.<br /><searchLink fieldCode="AU" term="%22Monaco+F%22">Monaco F</searchLink>; Departement. of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum - University of Bologna, Bologna, Italy.; Cardiothoracic and Vascular Anesthesia and Intensive Care, IRCCS Azienda Ospedaliero-Universitaria Sant'Orsola, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Zangrillo+A%22">Zangrillo A</searchLink>; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Piemonti+L%22">Piemonti L</searchLink>; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.; Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.
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