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Hepatokine fibrinogen-like protein 1 drives liver-kidney crosstalk to promote renal fibrosis.

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Title: Hepatokine fibrinogen-like protein 1 drives liver-kidney crosstalk to promote renal fibrosis.
Authors: Wu WH; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.; School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China., Zhu LZ; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China., Liu K; Department of Nephrology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Cao L; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China., Fan YM; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China., Zhou P; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China., Zhang Y; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China., Ma G; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.; Pukou Hospital of Chinese Medicine affiliated to China Pharmaceutical University, Nanjing, China., Liu JF; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China., Liu BL; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China., Qi LW; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China. qilw@cpu.edu.cn.; School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China. qilw@cpu.edu.cn., Liu Q; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China. liuquncpu@126.com.
Source: Nature communications [Nat Commun] 2026 Jan 09; Vol. 17 (1), pp. 1453. Date of Electronic Publication: 2026 Jan 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Hepatokine fibrinogen-like protein 1 drives liver-kidney crosstalk to promote renal fibrosis.
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  Data: <searchLink fieldCode="AU" term="%22Wu+WH%22">Wu WH</searchLink>; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.; School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Zhu+LZ%22">Zhu LZ</searchLink>; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Liu+K%22">Liu K</searchLink>; Department of Nephrology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Cao+L%22">Cao L</searchLink>; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Fan+YM%22">Fan YM</searchLink>; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Zhou+P%22">Zhou P</searchLink>; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Ma+G%22">Ma G</searchLink>; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.; Pukou Hospital of Chinese Medicine affiliated to China Pharmaceutical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Liu+JF%22">Liu JF</searchLink>; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Liu+BL%22">Liu BL</searchLink>; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Qi+LW%22">Qi LW</searchLink>; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China. qilw@cpu.edu.cn.; School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China. qilw@cpu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Liu+Q%22">Liu Q</searchLink>; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China. liuquncpu@126.com.
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