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Artificial thymic organoid culture generates functional iPSC-derived CD4+ invariant natural killer T cells.

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Title: Artificial thymic organoid culture generates functional iPSC-derived CD4+ invariant natural killer T cells.
Authors: Shiina S; Department of Cell Growth and Differentiation, Shin Kaneko Laboratory, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.; Takeda-CiRA Joint Program (T-CiRA), Fujisawa, Kanagawa, Japan., Ueda T; Department of Cell Growth and Differentiation, Shin Kaneko Laboratory, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan., Iriguchi S; Department of Cell Growth and Differentiation, Shin Kaneko Laboratory, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.; Takeda-CiRA Joint Program (T-CiRA), Fujisawa, Kanagawa, Japan., Uemura Y; Division of Cancer Immunotherapy, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Japan., Kaneko S; Department of Cell Growth and Differentiation, Shin Kaneko Laboratory, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan. kaneko.shin@cira.kyoto-u.ac.jp.; Takeda-CiRA Joint Program (T-CiRA), Fujisawa, Kanagawa, Japan. kaneko.shin@cira.kyoto-u.ac.jp.; Laboratory of Cancer Immunotherapy and Immunology, Transborder Medical Research Center, University of Tsukuba, Tsukuba, Japan. kaneko.shin@cira.kyoto-u.ac.jp.
Source: Communications biology [Commun Biol] 2026 Jan 09; Vol. 9 (1), pp. 185. Date of Electronic Publication: 2026 Jan 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Artificial thymic organoid culture generates functional iPSC-derived CD4+ invariant natural killer T cells.
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  Data: <searchLink fieldCode="AU" term="%22Shiina+S%22">Shiina S</searchLink>; Department of Cell Growth and Differentiation, Shin Kaneko Laboratory, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.; Takeda-CiRA Joint Program (T-CiRA), Fujisawa, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Ueda+T%22">Ueda T</searchLink>; Department of Cell Growth and Differentiation, Shin Kaneko Laboratory, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Iriguchi+S%22">Iriguchi S</searchLink>; Department of Cell Growth and Differentiation, Shin Kaneko Laboratory, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.; Takeda-CiRA Joint Program (T-CiRA), Fujisawa, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Uemura+Y%22">Uemura Y</searchLink>; Division of Cancer Immunotherapy, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Japan.<br /><searchLink fieldCode="AU" term="%22Kaneko+S%22">Kaneko S</searchLink>; Department of Cell Growth and Differentiation, Shin Kaneko Laboratory, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan. kaneko.shin@cira.kyoto-u.ac.jp.; Takeda-CiRA Joint Program (T-CiRA), Fujisawa, Kanagawa, Japan. kaneko.shin@cira.kyoto-u.ac.jp.; Laboratory of Cancer Immunotherapy and Immunology, Transborder Medical Research Center, University of Tsukuba, Tsukuba, Japan. kaneko.shin@cira.kyoto-u.ac.jp.
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  Data: <searchLink fieldCode="JN" term="%22101719179%22">Communications biology</searchLink> [Commun Biol] 2026 Jan 09; Vol. 9 (1), pp. 185. <i>Date of Electronic Publication: </i>2026 Jan 09.
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        Value: 10.1038/s42003-025-09462-1
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        Text: English
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      – TitleFull: Artificial thymic organoid culture generates functional iPSC-derived CD4+ invariant natural killer T cells.
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            NameFull: Shiina S
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            NameFull: Ueda T
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              Text: 2026 Jan 09
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