Exploiting the polypharmacology of alectinib for synergistic RNA splicing disruption with RBM39 degraders.
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| Title: | Exploiting the polypharmacology of alectinib for synergistic RNA splicing disruption with RBM39 degraders. |
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| Authors: | Ma Y; Department of Surgery & Cancer, Imperial College London, London, UK., Poon E; Division of Clinical Studies, The Institute of Cancer Research, London, UK., Jin C; Department of Surgery & Cancer, Imperial College London, London, UK., Martins da Costa B; Division of Clinical Studies, The Institute of Cancer Research, London, UK., Xu Y; Department of Surgery & Cancer, Imperial College London, London, UK., Quazi S; Department of Surgery & Cancer, Imperial College London, London, UK., Zourdoumis N; Department of Surgery & Cancer, Imperial College London, London, UK., Wickremesinghe C; Department of Surgery & Cancer, Imperial College London, London, UK., Chesler L; Division of Clinical Studies, The Institute of Cancer Research, London, UK., Keun HC; Department of Surgery & Cancer, Imperial College London, London, UK. Electronic address: h.keun@imperial.ac.uk., Nijhuis A; Department of Surgery & Cancer, Imperial College London, London, UK. Electronic address: a.nijhuis@imperial.ac.uk. |
| Source: | Cell reports [Cell Rep] 2026 Jan 27; Vol. 45 (1), pp. 116784. Date of Electronic Publication: 2026 Jan 08. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41518614 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Exploiting the polypharmacology of alectinib for synergistic RNA splicing disruption with RBM39 degraders. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Ma+Y%22">Ma Y</searchLink>; Department of Surgery & Cancer, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Poon+E%22">Poon E</searchLink>; Division of Clinical Studies, The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Jin+C%22">Jin C</searchLink>; Department of Surgery & Cancer, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Martins+da+Costa+B%22">Martins da Costa B</searchLink>; Division of Clinical Studies, The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Department of Surgery & Cancer, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Quazi+S%22">Quazi S</searchLink>; Department of Surgery & Cancer, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Zourdoumis+N%22">Zourdoumis N</searchLink>; Department of Surgery & Cancer, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Wickremesinghe+C%22">Wickremesinghe C</searchLink>; Department of Surgery & Cancer, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Chesler+L%22">Chesler L</searchLink>; Division of Clinical Studies, The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Keun+HC%22">Keun HC</searchLink>; Department of Surgery & Cancer, Imperial College London, London, UK. Electronic address: h.keun@imperial.ac.uk.<br /><searchLink fieldCode="AU" term="%22Nijhuis+A%22">Nijhuis A</searchLink>; Department of Surgery & Cancer, Imperial College London, London, UK. Electronic address: a.nijhuis@imperial.ac.uk. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2026 Jan 27; Vol. 45 (1), pp. 116784. <i>Date of Electronic Publication: </i>2026 Jan 08. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101573691 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2211-1247 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Rep <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41518614 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.celrep.2025.116784 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 116784 Titles: – TitleFull: Exploiting the polypharmacology of alectinib for synergistic RNA splicing disruption with RBM39 degraders. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ma Y – PersonEntity: Name: NameFull: Poon E – PersonEntity: Name: NameFull: Jin C – PersonEntity: Name: NameFull: Martins da Costa B – PersonEntity: Name: NameFull: Xu Y – PersonEntity: Name: NameFull: Quazi S – PersonEntity: Name: NameFull: Zourdoumis N – PersonEntity: Name: NameFull: Wickremesinghe C – PersonEntity: Name: NameFull: Chesler L – PersonEntity: Name: NameFull: Keun HC – PersonEntity: Name: NameFull: Nijhuis A IsPartOfRelationships: – BibEntity: Dates: – D: 27 M: 01 Text: 2026 Jan 27 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2211-1247 Numbering: – Type: volume Value: 45 – Type: issue Value: 1 Titles: – TitleFull: Cell reports Type: main |
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