The long-term effectiveness of the anti-obesity medication phentermine (LEAP) trial: Rationale, design, and baseline characteristics.

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Title: The long-term effectiveness of the anti-obesity medication phentermine (LEAP) trial: Rationale, design, and baseline characteristics.
Authors: Young CB; Department of Epidemiology and Prevention, Medical Center Blvd., Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. Electronic address: Caroline.B.Young@Advocatehealth.org., Rives E; Department of Biostatistics and Data Science, Medical Center Blvd., Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. Electronic address: Emily.Rives@Advocatehealth.org., Gudzune KA; American Board of Obesity Medicine Foundation, 2696 S. Colorado Blvd., Denver, CO 80222, USA. Electronic address: gudzune@abomfoundation.org., Jaeger BC; Department of Biostatistics and Data Science, Medical Center Blvd., Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. Electronic address: Byron.Jaeger@Advocatehealth.org., Simmons CG; Department of Biostatistics and Data Science, Medical Center Blvd., Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. Electronic address: Courtney.Simmons@Advocatehealth.org., White BN; Department of Biostatistics and Data Science, Medical Center Blvd., Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. Electronic address: Brian.N.White@Advocatehealth.org., Hooker SA; HealthPartners Institute, 8170 33rd Ave S, Bloomington, MN 55425, USA. Electronic address: stephanie.a.hooker@healthpartners.com., Horn DB; Center for Obesity Medicine and Metabolic Performance, University of Texas McGovern Medical School, 6500 West Loop South, Bellaire, TX 77401, USA. Electronic address: deborah.b.horn@uth.tmc.edu., Young DR; Department of Research & Evaluation, Kaiser Permanente Southern California, 100 South Los Robles Ave, Pasadena, CA 91101, USA. Electronic address: Deborah.R.Young@kp.org., Vesely J; HealthPartners Institute, 8170 33rd Ave S, Bloomington, MN 55425, USA. Electronic address: jennifer.vesely@parknicollet.com., Velazquez A; Jim and Eleanor Randall Department of Surgery, Center for Weight Management and Metabolic Health, Cedars Sinai Medical Center, 8635 W 3rd St., Los Angeles, CA 90048, USA. Electronic address: amanda.velazquez@cshs.org., Price C; Department of Internal Medicine, Section on Endocrinology, Medical Center Blvd., Wake Forest University School of Medicine, Winston-Salem, NA 27157, USA. Electronic address: Catherine.Price@Advocatehealth.org., Cook SD; HealthPartners Institute, 8170 33rd Ave S, Bloomington, MN 55425, USA. Electronic address: shelly.d.cook@healthpartners.com., Martin-Fernandez K; Atrium Health Wake Forest Baptist Weight Management Center, Medical Center Blvd., Winston-Salem, NC 27157, USA. Electronic address: Katy.Martinfernandez@Advocatehealth.org., Inzhakova G; Department of Research & Evaluation, Kaiser Permanente Southern California, 100 South Los Robles Ave, Pasadena, CA 91101, USA. Electronic address: galina.inzhakova@kp.org., Pajewski NM; Department of Biostatistics and Data Science, Medical Center Blvd., Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. Electronic address: Nicholas.Pajewski@Advocatehealth.org., Ard JD; Department of Epidemiology and Prevention, Medical Center Blvd., Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. Electronic address: Jamy.Ard@Advocatehealth.org., Lewis KH; Department of Epidemiology and Prevention, Medical Center Blvd., Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. Electronic address: Kristina.Lewis@Advocatehealth.org.
Source: Contemporary clinical trials [Contemp Clin Trials] 2026 Feb; Vol. 161, pp. 108219. Date of Electronic Publication: 2026 Jan 08.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101242342 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-2030 (Electronic) Linking ISSN: 15517144 NLM ISO Abbreviation: Contemp Clin Trials Subsets: MEDLINE
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  Data: The long-term effectiveness of the anti-obesity medication phentermine (LEAP) trial: Rationale, design, and baseline characteristics.
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  Data: <searchLink fieldCode="AU" term="%22Young+CB%22">Young CB</searchLink>; Department of Epidemiology and Prevention, Medical Center Blvd., Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. Electronic address: Caroline.B.Young@Advocatehealth.org.<br /><searchLink fieldCode="AU" term="%22Rives+E%22">Rives E</searchLink>; Department of Biostatistics and Data Science, Medical Center Blvd., Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. Electronic address: Emily.Rives@Advocatehealth.org.<br /><searchLink fieldCode="AU" term="%22Gudzune+KA%22">Gudzune KA</searchLink>; American Board of Obesity Medicine Foundation, 2696 S. Colorado Blvd., Denver, CO 80222, USA. Electronic address: gudzune@abomfoundation.org.<br /><searchLink fieldCode="AU" term="%22Jaeger+BC%22">Jaeger BC</searchLink>; Department of Biostatistics and Data Science, Medical Center Blvd., Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. Electronic address: Byron.Jaeger@Advocatehealth.org.<br /><searchLink fieldCode="AU" term="%22Simmons+CG%22">Simmons CG</searchLink>; Department of Biostatistics and Data Science, Medical Center Blvd., Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. Electronic address: Courtney.Simmons@Advocatehealth.org.<br /><searchLink fieldCode="AU" term="%22White+BN%22">White BN</searchLink>; Department of Biostatistics and Data Science, Medical Center Blvd., Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. Electronic address: Brian.N.White@Advocatehealth.org.<br /><searchLink fieldCode="AU" term="%22Hooker+SA%22">Hooker SA</searchLink>; HealthPartners Institute, 8170 33rd Ave S, Bloomington, MN 55425, USA. Electronic address: stephanie.a.hooker@healthpartners.com.<br /><searchLink fieldCode="AU" term="%22Horn+DB%22">Horn DB</searchLink>; Center for Obesity Medicine and Metabolic Performance, University of Texas McGovern Medical School, 6500 West Loop South, Bellaire, TX 77401, USA. Electronic address: deborah.b.horn@uth.tmc.edu.<br /><searchLink fieldCode="AU" term="%22Young+DR%22">Young DR</searchLink>; Department of Research & Evaluation, Kaiser Permanente Southern California, 100 South Los Robles Ave, Pasadena, CA 91101, USA. Electronic address: Deborah.R.Young@kp.org.<br /><searchLink fieldCode="AU" term="%22Vesely+J%22">Vesely J</searchLink>; HealthPartners Institute, 8170 33rd Ave S, Bloomington, MN 55425, USA. Electronic address: jennifer.vesely@parknicollet.com.<br /><searchLink fieldCode="AU" term="%22Velazquez+A%22">Velazquez A</searchLink>; Jim and Eleanor Randall Department of Surgery, Center for Weight Management and Metabolic Health, Cedars Sinai Medical Center, 8635 W 3rd St., Los Angeles, CA 90048, USA. Electronic address: amanda.velazquez@cshs.org.<br /><searchLink fieldCode="AU" term="%22Price+C%22">Price C</searchLink>; Department of Internal Medicine, Section on Endocrinology, Medical Center Blvd., Wake Forest University School of Medicine, Winston-Salem, NA 27157, USA. Electronic address: Catherine.Price@Advocatehealth.org.<br /><searchLink fieldCode="AU" term="%22Cook+SD%22">Cook SD</searchLink>; HealthPartners Institute, 8170 33rd Ave S, Bloomington, MN 55425, USA. Electronic address: shelly.d.cook@healthpartners.com.<br /><searchLink fieldCode="AU" term="%22Martin-Fernandez+K%22">Martin-Fernandez K</searchLink>; Atrium Health Wake Forest Baptist Weight Management Center, Medical Center Blvd., Winston-Salem, NC 27157, USA. Electronic address: Katy.Martinfernandez@Advocatehealth.org.<br /><searchLink fieldCode="AU" term="%22Inzhakova+G%22">Inzhakova G</searchLink>; Department of Research & Evaluation, Kaiser Permanente Southern California, 100 South Los Robles Ave, Pasadena, CA 91101, USA. Electronic address: galina.inzhakova@kp.org.<br /><searchLink fieldCode="AU" term="%22Pajewski+NM%22">Pajewski NM</searchLink>; Department of Biostatistics and Data Science, Medical Center Blvd., Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. Electronic address: Nicholas.Pajewski@Advocatehealth.org.<br /><searchLink fieldCode="AU" term="%22Ard+JD%22">Ard JD</searchLink>; Department of Epidemiology and Prevention, Medical Center Blvd., Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. Electronic address: Jamy.Ard@Advocatehealth.org.<br /><searchLink fieldCode="AU" term="%22Lewis+KH%22">Lewis KH</searchLink>; Department of Epidemiology and Prevention, Medical Center Blvd., Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. Electronic address: Kristina.Lewis@Advocatehealth.org.
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  Data: <searchLink fieldCode="JN" term="%22101242342%22">Contemporary clinical trials</searchLink> [Contemp Clin Trials] 2026 Feb; Vol. 161, pp. 108219. <i>Date of Electronic Publication: </i>2026 Jan 08.
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