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Tumor cell intrinsic dsRNA innate immune response triggered by PARP inhibitor is compromised in BRCA1 deficient breast cancer by repressing IRF3.

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Title: Tumor cell intrinsic dsRNA innate immune response triggered by PARP inhibitor is compromised in BRCA1 deficient breast cancer by repressing IRF3.
Authors: Zhang C; Cancer Centre, University of Macau, Taipa, 999078, Macau SAR.; Centre for Precision Medicine Research and Training, University of Macau, Taipa, 999078, Macau SAR.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, 999078, Macau SAR.; Faculty of Health Sciences, University of Macau, Taipa, 999078, Macau SAR., Zhou JB; Cancer Centre, University of Macau, Taipa, 999078, Macau SAR.; Centre for Precision Medicine Research and Training, University of Macau, Taipa, 999078, Macau SAR.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, 999078, Macau SAR.; Faculty of Health Sciences, University of Macau, Taipa, 999078, Macau SAR., Lei JH; Cancer Centre, University of Macau, Taipa, 999078, Macau SAR.; Centre for Precision Medicine Research and Training, University of Macau, Taipa, 999078, Macau SAR.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, 999078, Macau SAR.; Faculty of Health Sciences, University of Macau, Taipa, 999078, Macau SAR., Ang IL; Cancer Centre, University of Macau, Taipa, 999078, Macau SAR.; Centre for Precision Medicine Research and Training, University of Macau, Taipa, 999078, Macau SAR.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, 999078, Macau SAR.; Faculty of Health Sciences, University of Macau, Taipa, 999078, Macau SAR., Miao K; Cancer Centre, University of Macau, Taipa, 999078, Macau SAR.; Centre for Precision Medicine Research and Training, University of Macau, Taipa, 999078, Macau SAR.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, 999078, Macau SAR.; Faculty of Health Sciences, University of Macau, Taipa, 999078, Macau SAR., Xu X; Cancer Centre, University of Macau, Taipa, 999078, Macau SAR.; Centre for Precision Medicine Research and Training, University of Macau, Taipa, 999078, Macau SAR.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, 999078, Macau SAR.; Faculty of Health Sciences, University of Macau, Taipa, 999078, Macau SAR., Poon TCW; Cancer Centre, University of Macau, Taipa, 999078, Macau SAR.; Centre for Precision Medicine Research and Training, University of Macau, Taipa, 999078, Macau SAR.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, 999078, Macau SAR.; Faculty of Health Sciences, University of Macau, Taipa, 999078, Macau SAR.; Pilot Laboratory, University of Macau, Taipa, 999078, Macau SAR.; Institute of Translational Medicine, University of Macau, Taipa, 999078, Macau SAR., Cheung E; Cancer Centre, University of Macau, Taipa, 999078, Macau SAR.; Centre for Precision Medicine Research and Training, University of Macau, Taipa, 999078, Macau SAR.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, 999078, Macau SAR.; Faculty of Health Sciences, University of Macau, Taipa, 999078, Macau SAR., Deng CX; Cancer Centre, University of Macau, Taipa, 999078, Macau SAR.; Centre for Precision Medicine Research and Training, University of Macau, Taipa, 999078, Macau SAR.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, 999078, Macau SAR.; Faculty of Health Sciences, University of Macau, Taipa, 999078, Macau SAR.
Source: Protein & cell [Protein Cell] 2026 Jan 10. Date of Electronic Publication: 2026 Jan 10.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: Germany NLM ID: 101532368 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1674-8018 (Electronic) Linking ISSN: 1674800X NLM ISO Abbreviation: Protein Cell Subsets: MEDLINE
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  Data: Tumor cell intrinsic dsRNA innate immune response triggered by PARP inhibitor is compromised in BRCA1 deficient breast cancer by repressing IRF3.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; Cancer Centre, University of Macau, Taipa, 999078, Macau SAR.; Centre for Precision Medicine Research and Training, University of Macau, Taipa, 999078, Macau SAR.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, 999078, Macau SAR.; Faculty of Health Sciences, University of Macau, Taipa, 999078, Macau SAR.<br /><searchLink fieldCode="AU" term="%22Zhou+JB%22">Zhou JB</searchLink>; Cancer Centre, University of Macau, Taipa, 999078, Macau SAR.; Centre for Precision Medicine Research and Training, University of Macau, Taipa, 999078, Macau SAR.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, 999078, Macau SAR.; Faculty of Health Sciences, University of Macau, Taipa, 999078, Macau SAR.<br /><searchLink fieldCode="AU" term="%22Lei+JH%22">Lei JH</searchLink>; Cancer Centre, University of Macau, Taipa, 999078, Macau SAR.; Centre for Precision Medicine Research and Training, University of Macau, Taipa, 999078, Macau SAR.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, 999078, Macau SAR.; Faculty of Health Sciences, University of Macau, Taipa, 999078, Macau SAR.<br /><searchLink fieldCode="AU" term="%22Ang+IL%22">Ang IL</searchLink>; Cancer Centre, University of Macau, Taipa, 999078, Macau SAR.; Centre for Precision Medicine Research and Training, University of Macau, Taipa, 999078, Macau SAR.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, 999078, Macau SAR.; Faculty of Health Sciences, University of Macau, Taipa, 999078, Macau SAR.<br /><searchLink fieldCode="AU" term="%22Miao+K%22">Miao K</searchLink>; Cancer Centre, University of Macau, Taipa, 999078, Macau SAR.; Centre for Precision Medicine Research and Training, University of Macau, Taipa, 999078, Macau SAR.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, 999078, Macau SAR.; Faculty of Health Sciences, University of Macau, Taipa, 999078, Macau SAR.<br /><searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; Cancer Centre, University of Macau, Taipa, 999078, Macau SAR.; Centre for Precision Medicine Research and Training, University of Macau, Taipa, 999078, Macau SAR.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, 999078, Macau SAR.; Faculty of Health Sciences, University of Macau, Taipa, 999078, Macau SAR.<br /><searchLink fieldCode="AU" term="%22Poon+TCW%22">Poon TCW</searchLink>; Cancer Centre, University of Macau, Taipa, 999078, Macau SAR.; Centre for Precision Medicine Research and Training, University of Macau, Taipa, 999078, Macau SAR.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, 999078, Macau SAR.; Faculty of Health Sciences, University of Macau, Taipa, 999078, Macau SAR.; Pilot Laboratory, University of Macau, Taipa, 999078, Macau SAR.; Institute of Translational Medicine, University of Macau, Taipa, 999078, Macau SAR.<br /><searchLink fieldCode="AU" term="%22Cheung+E%22">Cheung E</searchLink>; Cancer Centre, University of Macau, Taipa, 999078, Macau SAR.; Centre for Precision Medicine Research and Training, University of Macau, Taipa, 999078, Macau SAR.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, 999078, Macau SAR.; Faculty of Health Sciences, University of Macau, Taipa, 999078, Macau SAR.<br /><searchLink fieldCode="AU" term="%22Deng+CX%22">Deng CX</searchLink>; Cancer Centre, University of Macau, Taipa, 999078, Macau SAR.; Centre for Precision Medicine Research and Training, University of Macau, Taipa, 999078, Macau SAR.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, 999078, Macau SAR.; Faculty of Health Sciences, University of Macau, Taipa, 999078, Macau SAR.
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        Value: 10.1093/procel/pwaf104
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      – Code: eng
        Text: English
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      – TitleFull: Tumor cell intrinsic dsRNA innate immune response triggered by PARP inhibitor is compromised in BRCA1 deficient breast cancer by repressing IRF3.
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              Text: 2026 Jan 10
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              Y: 2026
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