Large-scale blood pressure GWAS accounting for gene-depression interactions in 564,680 individuals from diverse populations.
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| Title: | Large-scale blood pressure GWAS accounting for gene-depression interactions in 564,680 individuals from diverse populations. |
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| Authors: | Lee S; Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA; Human Genetics Center, Department of Epidemiology, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA., Miller CL; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA., Bentley AR; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Brown MR; Human Genetics Center, Department of Epidemiology, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA., Nagarajan P; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Morrison JL; Division of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA., Schwander K; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Westerman K; Clinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA., Kho M; Graduate School of Data Science, Seoul National University, Seoul, South Korea., Kraja AT; University of Mississippi Medical Center, Jackson, MS, USA., de Vries PS; Human Genetics Center, Department of Epidemiology, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA., Ammous F; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Aschard H; Department of Computational Biology, France Institut Pasteur, Université Paris Cité, 75015 Paris, France., Bartz TM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA; Department of Biostatistics, University of Washington, Seattle, WA, USA., Do A; Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA., Dupont CT; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Gudmundsdottir V; Icelandic Heart Association, Kopavogur, Iceland; Faculty of Medicine, Department of Health Sciences, University of Iceland, Reykjavik, Iceland., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Harris SE; Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh, UK., Hikino K; Laboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan., Huang Z; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA., Lefevre C; Department of Data Sciences, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia., Lyytikäinen LP; Finnish Cardiovascular Research Center - Tampere, Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Milaneschi Y; Department of Psychiatry, Amsterdam UMC/Vrije Universiteit, Amsterdam, the Netherlands., Nardone GG; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy., Santin A; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy., Schmidt H; Department of Molecular Biology and Biochemistry, Medical University Graz, Graz, Styria, Austria., Shen B; Laboratory of Epidemiology and Population Sciences, Health Disparities Research Section, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Sofer T; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; CardioVascular Institute (CVI), Beth Israel Deaconess Medical Center, Boston, MA, USA., Sun Q; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Tan YA; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Tang J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Thériault S; Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval, Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Quebec City, QC, Canada., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Ware EB; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Weiss S; Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University Medicine Greifswald, Greifswald, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany., Xing WY; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Sciences Key Laboratory, Capital Medical University, Beijing, China., Yu C; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia., Zhao W; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Ansari MAY; Department of Data Science, University of Mississippi Medical Center, Jackson, MS, USA., Anugu P; Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA., Attia JR; School of Medicine and Public Health, College of Health Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW, Australia., Bazzano LA; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Breyer M; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Cade B; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA., Chen G; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Collins S; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Corley J; Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh, UK., Davies G; Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh, UK., Dörr M; German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany; Department of Internal Medicine B, Cardiology, Angiology, Pneumology & Intensive Care Medicine, University Medicine Greifswald, Greifswald, Mecklenburg-Western Pomerania, Germany., Du J; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Edwards TL; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Faquih T; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Fohner AE; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA., Fretts AM; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA., Gangireddy S; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Gepner A; Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Graff M; Cardiovascular Disease (CVD) Genetic Epidemiology Laboratory, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Hofer E; Department of Neurology, Medical University Graz, Graz, Styria, Austria; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Styria, Austria., Homuth G; Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Hood MM; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Jie X; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Sciences Key Laboratory, Capital Medical University, Beijing, China., Kähönen M; Finnish Cardiovascular Research Center - Tampere, Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Karvonen-Gutierrez CA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Launer LJ; Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Levy D; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA; Framingham Heart Study, Framingham, MA, USA., Maheshwari M; Metabolism Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Martin LW; Department of Cardiology, George Washington University, Washington, DC, USA., Matsuda K; Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan., McNeil JJ; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Okochi T; Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan., Raffield LM; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Raitakari OT; Centre for Population Health Research, Department of Clinical Physiology and Nuclear Medicine, InFLAMES Research Flagship, Turku University Hospital and University of Turku, Turku, Finland., Risch L; Faculty of Medical Sciences, Institute for Laboratory Medicine, Private University in the Principality of Liechtenstein, Vaduz, Liechtenstein; Center of Laboratory Medicine, Institute of Clinical Chemistry, University of Bern and Inselspital, Bern, Switzerland., Risch M; Central Laboratory, Cantonal Hospital Graubünden, Chur, Switzerland; Dr. Risch Medical Laboratory, Vaduz, Liechtenstein., Roux AD; Urban Health Collaborative, Department of Epidemiology and Biostatistics, Drexel University, Philadelphia, PA, USA., Ruiz-Narvaez EA; Department of Nutritional Sciences, University of Michigan, Ann Arbor, MI, USA., Russ TC; Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Division of Psychiatry, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK., Saito T; Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan., Schreiner PJ; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Scott RJ; School of Medicine and Public Health, College of Health Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW, Australia., Shikany J; Division of General Internal Medicine and Population Science, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Smith JA; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Spedicati B; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy., Tai ES; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Taylor AM; Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh, UK., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Tesolin P; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy., van Dam RM; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore; Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA., Wang R; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK., Wenbin W; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Xie T; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Young KL; Cardiovascular Disease (CVD) Genetic Epidemiology Laboratory, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Zhang R; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA., Zonderman AB; Laboratory of Epidemiology and Population Sciences, Health Disparities Research Section, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Concas MP; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy., Conen D; Population Health Research Institute, Department of Medicine, McMaster University, Hamilton, ON, Canada., Cox SR; Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh, UK., Evans MK; Laboratory of Epidemiology and Population Sciences, Health Disparities Research Section, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Fox ER; Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA., de Las Fuentes L; Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA; Cardiovascular Division, Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Giri A; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Division of Quantitative and Clinical Sciences, Department of Obstetrics and Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA., Girotto G; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Mecklenburg-Western Pomerania, Germany., Gu C; Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland; Faculty of Medicine, Department of Health Sciences, University of Iceland, Reykjavik, Iceland., Harlow SD; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Holliday E; School of Medicine and Public Health, College of Health Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW, Australia., Jost JB; Rothschild Foundation Hospital, Institut Français de Myopie, Paris, France., Lacaze P; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia., Lee S; Graduate School of Data Science, Seoul National University, Seoul, South Korea., Lehtimäki T; Finnish Cardiovascular Research Center - Tampere, Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Li C; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Morrison AC; Human Genetics Center, Department of Epidemiology, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA., North KE; Cardiovascular Disease (CVD) Genetic Epidemiology Laboratory, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Penninx BWJH; Department of Psychiatry, Amsterdam UMC/Vrije Universiteit, Amsterdam, the Netherlands., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Province MM; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA., Redline S; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA., Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Rotimi CN; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Schmidt R; Department of Neurology, Medical University Graz, Graz, Styria, Austria., Sim X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Terao C; The Clinical Research Center at Shizuoka General Hospital, Shizuoka, Japan; Department of Applied Genetics at The School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Zhu X; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Franceschini N; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., O'Connell JR; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Jaquish CE; Division of Cardiovascular Science, Epidemiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Wang H; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA., Manning A; Metabolism Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Clinical and Translational Epidemiology Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Munroe PB; Clinical Pharmacology and Precision Medicine, Queen Mary University of London, London, UK., Rao DC; Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA., Chen H; Human Genetics Center, Department of Epidemiology, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA., Gauderman WJ; Division of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA., Bierut LJ; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA., Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Fornage M; Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA; Human Genetics Center, Department of Epidemiology, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA. Electronic address: myriam.fornage@uth.tmc.edu. |
| Corporate Authors: | Biobank Japan Project; Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan., Lifelines Cohort Study; Lifelines Biobank, Roden, the Netherlands. |
| Source: | HGG advances [HGG Adv] 2026 Apr 09; Vol. 7 (2), pp. 100566. Date of Electronic Publication: 2026 Jan 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101772885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-2477 (Electronic) Linking ISSN: 26662477 NLM ISO Abbreviation: HGG Adv Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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