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Pre- and in-hospital lactate ratio as a predictor of mortality in severe diabetic ketoacidosis: a multicenter prospective cohort study.

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Title: Pre- and in-hospital lactate ratio as a predictor of mortality in severe diabetic ketoacidosis: a multicenter prospective cohort study.
Authors: Sebastian-Valles F; Department of Endocrinology and Nutrition, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria de La Princesa, Universidad Autónoma de Madrid, 28006, Madrid, Spain; Group of Preventive Activities in the University Health Sciences Setting, University of Castilla-La Mancha, Albacete, 02071, Spain. Electronic address: Fernando.sebastian@estudiante.uam.es., Sampedro-Nuñez MA; Department of Endocrinology and Nutrition, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria de La Princesa, Universidad Autónoma de Madrid, 28006, Madrid, Spain., Arranz-Martin JA; Department of Endocrinology and Nutrition, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria de La Princesa, Universidad Autónoma de Madrid, 28006, Madrid, Spain., Navas-Moreno V; Department of Endocrinology and Nutrition, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria de La Princesa, Universidad Autónoma de Madrid, 28006, Madrid, Spain., Marazuela M; Department of Endocrinology and Nutrition, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria de La Princesa, Universidad Autónoma de Madrid, 28006, Madrid, Spain., López-Izquierdo R; Emergency Department. Hospital Universitario Rio Hortega, Gerencia Regional de Salud de Castilla y León, Valladolid, Spain; Faculty of Medicine, Universidad de Valladolid, Valladolid, Spain; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain., Del Pozo Vegas C; Faculty of Medicine, Universidad de Valladolid, Valladolid, Spain; Emergency Department, Hospital Clínico Universitario, Gerencia Regional de Salud de Castilla y León, Valladolid, Spain., Rabanales Soto J; Faculty of Nursing, University of Castilla la Mancha, Albacete, 02071, Spain; Faculty of Health Sciences, University of Castilla la Mancha, Talavera de la Reina, 45600, Toledo, Spain., Martín-Conty JL; Faculty of Health Sciences, University of Castilla la Mancha, Talavera de la Reina, 45600, Toledo, Spain; Technological Innovation Applied to Health Research Group (ITAS Group), Faculty of Health Sciences, University of de Castilla-La Mancha, Talavera de la Reina, 45600, Toledo, Spain; Evaluación de Cuidados de Salud (ECUSAL), Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), Toledo, 45071, Spain., Sanz-García A; Faculty of Health Sciences, University of Castilla la Mancha, Talavera de la Reina, 45600, Toledo, Spain; Technological Innovation Applied to Health Research Group (ITAS Group), Faculty of Health Sciences, University of de Castilla-La Mancha, Talavera de la Reina, 45600, Toledo, Spain; Evaluación de Cuidados de Salud (ECUSAL), Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), Toledo, 45071, Spain., Martín-Rodríguez F; Faculty of Medicine, Universidad de Valladolid, Valladolid, Spain; Prehospital Critical Care, Emergency Medical Services, Gerencia Regional de Salud de Castilla y León, Valladolid, Spain.
Source: European journal of internal medicine [Eur J Intern Med] 2026 Apr; Vol. 146, pp. 106706. Date of Electronic Publication: 2026 Jan 10.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9003220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0828 (Electronic) Linking ISSN: 09536205 NLM ISO Abbreviation: Eur J Intern Med Subsets: MEDLINE
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  Data: Pre- and in-hospital lactate ratio as a predictor of mortality in severe diabetic ketoacidosis: a multicenter prospective cohort study.
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  Data: <searchLink fieldCode="AU" term="%22Sebastian-Valles+F%22">Sebastian-Valles F</searchLink>; Department of Endocrinology and Nutrition, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria de La Princesa, Universidad Autónoma de Madrid, 28006, Madrid, Spain; Group of Preventive Activities in the University Health Sciences Setting, University of Castilla-La Mancha, Albacete, 02071, Spain. Electronic address: Fernando.sebastian@estudiante.uam.es.<br /><searchLink fieldCode="AU" term="%22Sampedro-Nuñez+MA%22">Sampedro-Nuñez MA</searchLink>; Department of Endocrinology and Nutrition, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria de La Princesa, Universidad Autónoma de Madrid, 28006, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Arranz-Martin+JA%22">Arranz-Martin JA</searchLink>; Department of Endocrinology and Nutrition, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria de La Princesa, Universidad Autónoma de Madrid, 28006, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Navas-Moreno+V%22">Navas-Moreno V</searchLink>; Department of Endocrinology and Nutrition, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria de La Princesa, Universidad Autónoma de Madrid, 28006, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Marazuela+M%22">Marazuela M</searchLink>; Department of Endocrinology and Nutrition, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria de La Princesa, Universidad Autónoma de Madrid, 28006, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22López-Izquierdo+R%22">López-Izquierdo R</searchLink>; Emergency Department. Hospital Universitario Rio Hortega, Gerencia Regional de Salud de Castilla y León, Valladolid, Spain; Faculty of Medicine, Universidad de Valladolid, Valladolid, Spain; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Del+Pozo+Vegas+C%22">Del Pozo Vegas C</searchLink>; Faculty of Medicine, Universidad de Valladolid, Valladolid, Spain; Emergency Department, Hospital Clínico Universitario, Gerencia Regional de Salud de Castilla y León, Valladolid, Spain.<br /><searchLink fieldCode="AU" term="%22Rabanales+Soto+J%22">Rabanales Soto J</searchLink>; Faculty of Nursing, University of Castilla la Mancha, Albacete, 02071, Spain; Faculty of Health Sciences, University of Castilla la Mancha, Talavera de la Reina, 45600, Toledo, Spain.<br /><searchLink fieldCode="AU" term="%22Martín-Conty+JL%22">Martín-Conty JL</searchLink>; Faculty of Health Sciences, University of Castilla la Mancha, Talavera de la Reina, 45600, Toledo, Spain; Technological Innovation Applied to Health Research Group (ITAS Group), Faculty of Health Sciences, University of de Castilla-La Mancha, Talavera de la Reina, 45600, Toledo, Spain; Evaluación de Cuidados de Salud (ECUSAL), Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), Toledo, 45071, Spain.<br /><searchLink fieldCode="AU" term="%22Sanz-García+A%22">Sanz-García A</searchLink>; Faculty of Health Sciences, University of Castilla la Mancha, Talavera de la Reina, 45600, Toledo, Spain; Technological Innovation Applied to Health Research Group (ITAS Group), Faculty of Health Sciences, University of de Castilla-La Mancha, Talavera de la Reina, 45600, Toledo, Spain; Evaluación de Cuidados de Salud (ECUSAL), Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), Toledo, 45071, Spain.<br /><searchLink fieldCode="AU" term="%22Martín-Rodríguez+F%22">Martín-Rodríguez F</searchLink>; Faculty of Medicine, Universidad de Valladolid, Valladolid, Spain; Prehospital Critical Care, Emergency Medical Services, Gerencia Regional de Salud de Castilla y León, Valladolid, Spain.
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  Data: <searchLink fieldCode="JN" term="%229003220%22">European journal of internal medicine</searchLink> [Eur J Intern Med] 2026 Apr; Vol. 146, pp. 106706. <i>Date of Electronic Publication: </i>2026 Jan 10.
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