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High-Dose vs Standard-Dose Influenza Vaccine in Older Adults With Diabetes: A Secondary Analysis of the DANFLU-2 Randomized Clinical Trial.

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Title: High-Dose vs Standard-Dose Influenza Vaccine in Older Adults With Diabetes: A Secondary Analysis of the DANFLU-2 Randomized Clinical Trial.
Authors: Nielsen AB; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Johansen ND; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Modin D; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Loiacono MM; Sanofi, Morristown, New Jersey.; Department of Epidemiology, University of Delaware, Newark, Delaware., Harris RC; Sanofi, Singapore., Dufournet M; Sanofi, Lyon, France., Larsen CS; Department of Clinical Medicine-Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.; Danske Lægers Vaccinations Service/European LifeCare Group, Søborg, Denmark., Larsen L; Department of Infectious Diseases, Odense University Hospital, Odense, Denmark., Wiese L; Department of Infectious Diseases, Zealand University Hospital, Roskilde, Denmark., Dalager-Pedersen M; Department of Infectious Diseases, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University Hospital, Aalborg, Denmark., Claggett BL; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Janstrup KH; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Bartholdy KV; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Bernholm KF; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Borchsenius JIH; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Davidovski FS; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Davodian LW; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Dons M; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Duus LS; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Espersen C; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Fussing FH; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Jensen AMR; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Landler NE; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Langhoff ACF; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Lassen MCH; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Ottosen CI; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Sengeløv M; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Skaarup KG; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Pareek M; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Müller-Wieland D; Department of Medicine I, University Hospital Aachen, Aachen, Germany., Solomon SD; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Landray MJ; Nuffield Department of Population Health, University of Oxford, Oxford, England., Gislason GH; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.; The Danish Heart Foundation, Copenhagen, Denmark., Køber L; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Sivapalan P; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.; Respiratory Medicine Section, Department of Medicine, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark., Martel CJ; Statens Serum Institut, Copenhagen, Denmark., Jensen JUS; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.; Respiratory Medicine Section, Department of Medicine, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark., Biering-Sørensen T; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Steno Diabetes Center Copenhagen, Herlev, Denmark.
Source: JAMA internal medicine [JAMA Intern Med] 2026 Mar 01; Vol. 186 (3), pp. 311-320.
Publication Type: Journal Article; Randomized Controlled Trial; Pragmatic Clinical Trial
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589534 Publication Model: Print Cited Medium: Internet ISSN: 2168-6114 (Electronic) Linking ISSN: 21686106 NLM ISO Abbreviation: JAMA Intern Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: High-Dose vs Standard-Dose Influenza Vaccine in Older Adults With Diabetes: A Secondary Analysis of the DANFLU-2 Randomized Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22Nielsen+AB%22">Nielsen AB</searchLink>; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Johansen+ND%22">Johansen ND</searchLink>; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Modin+D%22">Modin D</searchLink>; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Loiacono+MM%22">Loiacono MM</searchLink>; Sanofi, Morristown, New Jersey.; Department of Epidemiology, University of Delaware, Newark, Delaware.<br /><searchLink fieldCode="AU" term="%22Harris+RC%22">Harris RC</searchLink>; Sanofi, Singapore.<br /><searchLink fieldCode="AU" term="%22Dufournet+M%22">Dufournet M</searchLink>; Sanofi, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Larsen+CS%22">Larsen CS</searchLink>; Department of Clinical Medicine-Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.; Danske Lægers Vaccinations Service/European LifeCare Group, Søborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Larsen+L%22">Larsen L</searchLink>; Department of Infectious Diseases, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Wiese+L%22">Wiese L</searchLink>; Department of Infectious Diseases, Zealand University Hospital, Roskilde, Denmark.<br /><searchLink fieldCode="AU" term="%22Dalager-Pedersen+M%22">Dalager-Pedersen M</searchLink>; Department of Infectious Diseases, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University Hospital, Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Claggett+BL%22">Claggett BL</searchLink>; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Janstrup+KH%22">Janstrup KH</searchLink>; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Bartholdy+KV%22">Bartholdy KV</searchLink>; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Bernholm+KF%22">Bernholm KF</searchLink>; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Borchsenius+JIH%22">Borchsenius JIH</searchLink>; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Davidovski+FS%22">Davidovski FS</searchLink>; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Davodian+LW%22">Davodian LW</searchLink>; 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Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Fussing+FH%22">Fussing FH</searchLink>; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Jensen+AMR%22">Jensen AMR</searchLink>; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Landler+NE%22">Landler NE</searchLink>; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Langhoff+ACF%22">Langhoff ACF</searchLink>; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Lassen+MCH%22">Lassen MCH</searchLink>; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Ottosen+CI%22">Ottosen CI</searchLink>; 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Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Müller-Wieland+D%22">Müller-Wieland D</searchLink>; Department of Medicine I, University Hospital Aachen, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Solomon+SD%22">Solomon SD</searchLink>; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Landray+MJ%22">Landray MJ</searchLink>; Nuffield Department of Population Health, University of Oxford, Oxford, England.<br /><searchLink fieldCode="AU" term="%22Gislason+GH%22">Gislason GH</searchLink>; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.; The Danish Heart Foundation, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Køber+L%22">Køber L</searchLink>; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Sivapalan+P%22">Sivapalan P</searchLink>; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.; Respiratory Medicine Section, Department of Medicine, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Martel+CJ%22">Martel CJ</searchLink>; Statens Serum Institut, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Jensen+JUS%22">Jensen JUS</searchLink>; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.; Respiratory Medicine Section, Department of Medicine, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Biering-Sørensen+T%22">Biering-Sørensen T</searchLink>; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Steno Diabetes Center Copenhagen, Herlev, Denmark.
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