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PNPLA3 Genotype and Clinical Factors Impact Hepatocellular Carcinoma Risk: Findings From a Prospective Cohort Study.

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Title: PNPLA3 Genotype and Clinical Factors Impact Hepatocellular Carcinoma Risk: Findings From a Prospective Cohort Study.
Authors: Huang DQ; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore, Singapore., Zhang Z; Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Dorajoo R; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Khor CC; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Pham YT; University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, Pennsylvania, USA., Wang R; University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, Pennsylvania, USA., Behari J; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.; Pittsburgh Liver Research Center, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA., Yuan JM; Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, Pennsylvania, USA., Koh WP; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Institute for Human Development and Potential (IHDP), Agency for Science Technology and Research (A*STAR), Singapore, Singapore., Luu HN; Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.; Dr. Mary and Ron Neal Cancer Center, Houston Methodist Research Institute (HMRI), Houston, Texas, USA.
Source: Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2026 May; Vol. 63 (9), pp. 1272-1281. Date of Electronic Publication: 2026 Jan 12.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 8707234 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2036 (Electronic) Linking ISSN: 02692813 NLM ISO Abbreviation: Aliment Pharmacol Ther Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Huang+DQ%22">Huang DQ</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Dorajoo+R%22">Dorajoo R</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Khor+CC%22">Khor CC</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Pham+YT%22">Pham YT</searchLink>; University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Wang+R%22">Wang R</searchLink>; University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Behari+J%22">Behari J</searchLink>; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.; Pittsburgh Liver Research Center, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Yuan+JM%22">Yuan JM</searchLink>; Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Koh+WP%22">Koh WP</searchLink>; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Institute for Human Development and Potential (IHDP), Agency for Science Technology and Research (A*STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Luu+HN%22">Luu HN</searchLink>; Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.; Dr. Mary and Ron Neal Cancer Center, Houston Methodist Research Institute (HMRI), Houston, Texas, USA.
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  Data: <searchLink fieldCode="JN" term="%228707234%22">Alimentary pharmacology & therapeutics</searchLink> [Aliment Pharmacol Ther] 2026 May; Vol. 63 (9), pp. 1272-1281. <i>Date of Electronic Publication: </i>2026 Jan 12.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-Blackwell%22">Wiley-Blackwell </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8707234 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1365-2036 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202692813%22">02692813 </searchLink><i>NLM ISO Abbreviation: </i>Aliment Pharmacol Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1111/apt.70532
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              Text: 2026 May
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