Structural brain differences associated with panic disorder: an ENIGMA-Anxiety Working Group mega-analysis of 4924 individuals worldwide.
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| Title: | Structural brain differences associated with panic disorder: an ENIGMA-Anxiety Working Group mega-analysis of 4924 individuals worldwide. |
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| Authors: | Han LKM; Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. l.han@amsterdamumc.nl.; Orygen, Parkville, VIC, Australia. l.han@amsterdamumc.nl.; Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam, Netherlands. l.han@amsterdamumc.nl.; Amsterdam Neuroscience, Amsterdam, Netherlands. l.han@amsterdamumc.nl., Bruin WB; Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam, Netherlands.; Amsterdam Neuroscience, Amsterdam, Netherlands.; Amsterdam UMC location University of Amsterdam, Department of Psychiatry, Amsterdam, Netherlands.; Institute of Education & Child Studies, Leiden University, Leiden, Netherlands., Bas-Hoogendam JM; Developmental & Educational Psychology, Institute of Psychology, Leiden University, Leiden, The Netherlands.; Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.; Leiden Institute for Brain and Cognition, Leiden, The Netherlands., Groenewold NA; Department of Psychiatry and Mental Health, Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Hilbert K; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.; Department of Psychology, HMU Health and Medical University Erfurt, Erfurt, Germany., Winkler AM; Department of Human Genetics, University of Texas Rio Grande Valley, Brownsville, Texas, USA.; National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA., Zugman A; National Institutes of Health, National Institute of Mental Health, Section on Development and Affective Neuroscience, Bethesda, USA., Asami T; Department of Psychiatry, Yokohama City University School of Medicine, Yokohama, Japan., Barber JP; Adelphi University, Garden City, NY, USA.; University of Pennsylvania, Philadelphia, PA, USA., Benedetti F; Psychiatry & Clinical Psychobiology, Division of Neuroscience, IRCSS Ospedale San Raffaele, Milan, Italy., Blair RJR; Child and Adolescent Mental Health Centre, Mental Health Services, Copenhagen University Hospital - Mental Health services CPH, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Böhnlein J; Institute for Translational Psychiatry, University of Münster, Münster, Germany.; Clinical Psychology and Translational Psychotherapy, University of Münster, Münster, Germany., Brambilla P; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy., Breuer F; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Buckner RL; Department of Psychology and Center for Brain Science, Harvard University, Cambridge, MA, USA.; Department of Psychiatry and Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA., Bülow R; Institute for diagnostic radiology and neuroradiology, University Medicine Greifswald, 17475, Greifswald, Germany., Calkins ME; Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA., Chechko N; Max Planck Institute of Psychiatry, Munich, Germany.; Department of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine, RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.; Institute of Neuroscience and Medicine: JARA-Institute Brain Structure Function Relationship (INM 10), Jülich, Germany., Dannlowski U; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Dohm K; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Domschke K; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Dresler T; Department of Psychiatry and Psychotherapy, Tuebingen Center for Mental Health, University of Tuebingen, 72076, Tuebingen, Germany.; LEAD Graduate School & Research Network, University of Tuebingen, 72072, Tuebingen, Germany.; German Center for Mental Health (DZPG), partner site Tuebingen, Tübingen, Germany., Erhardt-Lehmann A; Max Planck Institute of Psychiatry, Munich, Germany.; Department of Psychiatry, University of Wuerzburg, Wuerzburg, Germany., Fonzo GA; Center for Psychedelic Research and Therapy, Department of Psychiatry and Behavioral Sciences, The University of Texas at Austin Dell Medical School, Austin, US., Forstner AJ; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.; Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany.; Centre for Human Genetics, University of Marburg, Marburg, Germany., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Grotegerd D; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Gur RE; Department of Psychiatry, Neurodevelopment & Psychosis Section, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA.; Lifespan Brain Institute (LiBI) at Penn & CHOP, Philadelphia, PA, USA., Gur RC; University of Pennsylvania, Philadelphia, PA, USA., Harmer C; Department of Psychiatry, University of Oxford, Oxford, UK.; Oxford Health NHS Trust, Warneford Hospital, Oxford, UK., Hofmann D; University of Münster, Münster, Germany., van den Heuvel OA; Amsterdam UMC, Department of Psychiatry, Department of Anatomy & Neurosciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Compulsivity Impulsivity & Attention program, Amsterdam, The Netherlands., Jahanshad N; Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Kircher TTJ; Department of Psychiatry, University of Marburg, Marburg, Germany., Koch K; Department of General Psychiatry, University of Tuebingen, Tuebingen, Germany., Laansma MA; Amsterdam UMC, Department of Psychiatry, Department of Anatomy & Neurosciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands., Langhammer T; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany., Lee SH; Department of Psychiatry, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea., Leehr EJ; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Maggioni E; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy., Marino CE; The Del Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Meinert S; Institute for Translational Psychiatry, University of Münster, Münster, Germany.; Institute for Translational Neuroscience, University of Münster, Münster, Germany., Meinert H; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Milrod B; Albert Einstein College of Medicine, New York City, NY, USA., Mwangi B; Center of Excellence on Mood Disorders, Louis A. Faillace, Houston, MD, USA.; Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, USA., Nielsen JA; Department of Psychology & Neuroscience Center, Brigham Young University, Provo, UT 84602, USA.; Center for Brain Science & Department of Psychology, Harvard University, Cambridge, MA, 02138, USA., Ohrmann P; University of Münster, Münster, Germany., Pantazatos SP; Department of Psychiatry, Columbia University Medical Center, New York, NY, USA.; New York State Psychiatric Institute, New York, NY, USA., Paulus MP; Laureate Institute for Brain Research, Tulsa, OK, USA.; University of Tulsa, Tulsa, OK, USA.; Department of Psychiatry and School of Public Health, University of California San Diego, La Jolla, CA, 92093, US., Penninx BWJH; Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam, Netherlands.; Amsterdam Neuroscience, Amsterdam, Netherlands., Poletti S; IRCCS Scientific Institute San Raffaele Hospital, Milan, Italy., Reinecke A; Department of Psychiatry, University of Oxford, Oxford, UK.; Oxford Health NHS Trust, Warneford Hospital, Oxford, UK., Ridderbusch IC; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Rjabtsenkov P; The Del Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Sämann PG; Max Planck Institute of Psychiatry, Munich, Germany., Satterthwaite TD; Penn Lifespan Informatics and Neuroimaging Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Penn-CHOP Lifespan Brain Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Schmaal L; Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.; Orygen, Parkville, VIC, Australia., Schrammen E; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Soares JC; Center of Excellence on Mood Disorders, Louis A. Faillace, Houston, MD, USA.; Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, USA., Solomonov N; Department of Psychiatry, Weill Cornell Medicine, New York, NY, USA., Stein MB; Department of Psychiatry and School of Public Health, University of California San Diego, La Jolla, CA, 92093, US., Straube B; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), University of Marburg, Marburg, Germany., Straube T; Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany., Suarez-Jimenez B; The Del Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.; University of Rochester, Center for Visual Sciences, Rochester, NY, USA., Smoller JW; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center for Precision Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Talati A; Department of Psychiatry, Columbia University Medical Center, New York, NY, USA.; New York State Psychiatric Institute, New York, NY, USA., Thomopoulos SI; Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Vazquez CE; The Del Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Völzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Wittfeld K; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Wu MJ; Center of Excellence on Mood Disorders, Louis A. Faillace, Houston, MD, USA.; Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, USA., Yang Y; Department of Experimental Psychopathology, Institute of Psychology, University of Hildesheim, Hildesheim, Germany., Zunta Soares GB; Center of Excellence on Mood Disorders, Louis A. Faillace, Houston, MD, USA.; Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, USA., Lueken U; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany., Thompson PM; Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Pine DS; National Institutes of Health, National Institute of Mental Health, Section on Development and Affective Neuroscience, Bethesda, USA., Stein DJ; SAMRC Unit on Risk & Resilience in Mental Disorders, Dept of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa., van der Wee NJA; Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.; Leiden Institute for Brain and Cognition, Leiden, The Netherlands., Veltman DJ; Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam, Netherlands., Aghajani M; Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam, Netherlands. m.aghajani@fsw.leidenuniv.nl.; Institute of Education & Child Studies, Leiden University, Leiden, Netherlands. m.aghajani@fsw.leidenuniv.nl. |
| Source: | Molecular psychiatry [Mol Psychiatry] 2026 May; Vol. 31 (5), pp. 2402-2417. Date of Electronic Publication: 2026 Jan 13. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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