Mixed-model and transcriptome-wide association analyses identify transcription factors and genes associated with colorectal cancer susceptibility.
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| Title: | Mixed-model and transcriptome-wide association analyses identify transcription factors and genes associated with colorectal cancer susceptibility. |
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| Authors: | Chen Z; Division of Epidemiology, Department of Medicine,sss Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Song W; Division of Epidemiology, Department of Medicine,sss Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Li Q; Division of Epidemiology, Department of Medicine,sss Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Li C; Division of Epidemiology, Department of Medicine,sss Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Wen W; Division of Epidemiology, Department of Medicine,sss Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Huyghe JR; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Law PJ; Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK., Fernandez-Rozadilla C; Edinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, UK.; Genomic Medicine Group, Instituto de Investigation Sanitaria de Santiago, Santiago de, Compostela, Spain., Timofeeva MN; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Danish Institute for Advanced Study, Department of Public Health, University of Southern Denmark, Odense, Denmark., Thomas M; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Schmit SL; Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University School of Medicine, Cleveland, OH, USA., Martin V; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain.; Gene-Environment Interactions and Health Research Group (GIIGAS), Institute of Biomedicine (IBIOMED), University of León, Leon, Spain., Devall M; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Dampier C; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Moratalla-Navarro F; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain.; Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain.; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.; Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain., Cai Q; Division of Epidemiology, Department of Medicine,sss Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Wang J; Division of Epidemiology, Department of Medicine,sss Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Shi J; Division of Epidemiology, Department of Medicine,sss Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Kweon SS; Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea.; Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun, South Korea., Tanikawa C; Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan., Jia WH; State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China., Shu X; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Long J; Division of Epidemiology, Department of Medicine,sss Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Gao J; Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, 227, South Chongqing Road, Shanghai, China., Kim J; Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Gyeonggi-do, Seoul, South Korea., Shin A; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul National University Cancer Research Institute, Seoul, Korea., Matsuo K; Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan.; Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Jee SH; Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, South Korea., Jung KJ; Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, South Korea., Wang N; Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China., Kim DH; Department of Social and Preventive Medicine, Hallym University College of Medicine, Okcheon-dong, South Korea., Ping J; Division of Epidemiology, Department of Medicine,sss Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Yang G; Division of Epidemiology, Department of Medicine,sss Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Shin MH; Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea., Ren Z; School of Public Health, Sun Yat-sen University, Guangzhou, China., Oh JH; Center for Colorectal Cancer, National Cancer Center Hospital, National Cancer Center, Gyeonggi-do, Seoul, South Korea., Oze I; Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan., Ahn YO; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul National University Cancer Research Institute, Seoul, Korea., Gao YT; State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Pan ZZ; State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China., Kamatani Y; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Yokohama, Japan.; Kyoto-McGill International Collaborative School in Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Van Kaer L; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Wu L; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Li B; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Matsuda K; Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan., Shu XO; Division of Epidemiology, Department of Medicine,sss Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Hsu L; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Dunlop MG; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Gruber SB; Department of Medical Oncology and Center for Precision Medicine, City of Hope National Medical Center, Duarte, CA, USA., Houlston R; Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK., Tomlinson I; Edinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, UK.; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK., Li L; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Lau KS; Epithelial Biology Center and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Moreno V; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain.; Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain.; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.; Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain., Casey G; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Peters U; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Zheng W; Division of Epidemiology, Department of Medicine,sss Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Guo X; Division of Epidemiology, Department of Medicine,sss Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA. xingyi.guo@vumc.org.; Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA. xingyi.guo@vumc.org. |
| Source: | Nature communications [Nat Commun] 2026 Jan 15; Vol. 17 (1), pp. 1377. Date of Electronic Publication: 2026 Jan 15. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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