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Multimodal antigenic escape to GPRC5D-targeted T cell engagers in multiple myeloma.

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Title: Multimodal antigenic escape to GPRC5D-targeted T cell engagers in multiple myeloma.
Authors: Lee H; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada., Ahn S; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada., Gonzales GA; Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada., Leblay N; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada., Barakat E; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada., Greening D; Department of Physiology and Pharmacology and the Live Cell Imaging Laboratory, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada., Colarusso P; Department of Physiology and Pharmacology and the Live Cell Imaging Laboratory, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada., Canton J; Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada., Benaoudia S; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada., Hasheminasabgorji E; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada., Poorebrahim M; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada., Jung D; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada., Truger M; MLL Munich Leukemia Laboratory, Munich, Germany., Jeong J; Department of Life Science, Pohang University of Science and Technology, Pohang, South Korea., Riedhammer C; Department of Internal Medicine 2, University Hospital of Würzburg, Würzburg, Germany., Einsele H; Department of Internal Medicine 2, University Hospital of Würzburg, Würzburg, Germany., Kortüm KM; Department of Internal Medicine 2, University Hospital of Würzburg, Würzburg, Germany., Eckmann J; Discovery Oncology, Roche Pharma Research and Early Development, Roche Innovation Center, Munich, Germany., Somandin J; Roche Innovation Center Zurich, Roche Pharma Research and Early Development (pRED), Schlieren, Switzerland., Engel SS; Laboratory for Hematological Diagnostics, MVZ, Heppenheim, Germany., Boise LH; Department of Hematology and Medical Oncology, Emory School of Medicine, and the Winship, Cancer Institute of Emory University Atlanta, Atlanta, GA, USA., Frenking JH; Heidelberg Myeloma Center, Department of Medicine V, Heidelberg University Hospital and Medical Faculty, Heidelberg, Germany.; CCU Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Weinhold N; Heidelberg Myeloma Center, Department of Medicine V, Heidelberg University Hospital and Medical Faculty, Heidelberg, Germany.; CCU Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Taouxi K; Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Athens, Greece., Kastritis E; Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Athens, Greece., Skerget S; Johnson & Johnson, Spring House, PA, USA., Vishwamitra D; Johnson & Johnson, Spring House, PA, USA., Cho Y; Department of Life Science, Pohang University of Science and Technology, Pohang, South Korea., Maura F; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Raab MS; Heidelberg Myeloma Center, Department of Medicine V, Heidelberg University Hospital and Medical Faculty, Heidelberg, Germany.; CCU Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Corre J; University of Toulouse, University Hospital, Unit for Genomics in Myeloma, IUCT Oncopole, CRCT, Toulouse, France., Rasche L; Department of Internal Medicine 2, University Hospital of Würzburg, Würzburg, Germany., Avet-Loiseau H; Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France., Neri P; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada., Bahlis NJ; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada. nbahlis@ucalgary.ca.
Source: Nature medicine [Nat Med] 2026 Mar; Vol. 32 (3), pp. 964-977. Date of Electronic Publication: 2026 Jan 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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