Targeting PAK4 promotes Gemcitabine-induced pyroptosis in pancreatic cancer via NLRP1/caspase-3/GSDME axis.
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| Title: | Targeting PAK4 promotes Gemcitabine-induced pyroptosis in pancreatic cancer via NLRP1/caspase-3/GSDME axis. |
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| Authors: | Lu T; Department of Cell Biology, Key Laboratory of Cell Biology, National Health Commission of the PRC and Key Laboratory of Medical Cell Biology, Ministry of Education of the PRC, School of Life Sciences, China Medical University, Shenyang, Liaoning, China.; Department of Pharmaceutical Neuroendocrinology, School of Pharmacy, China Medical University, Shenyang, Liaoning, China., Song Y; Department of Cell Biology, Key Laboratory of Cell Biology, National Health Commission of the PRC and Key Laboratory of Medical Cell Biology, Ministry of Education of the PRC, School of Life Sciences, China Medical University, Shenyang, Liaoning, China., Liang K; Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China., Zhang Z; Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China., Li Y; Department of Cell Biology, Key Laboratory of Cell Biology, National Health Commission of the PRC and Key Laboratory of Medical Cell Biology, Ministry of Education of the PRC, School of Life Sciences, China Medical University, Shenyang, Liaoning, China., Tan X; Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China. tanxd@sj-hospital.org., Li X; Department of Cell Biology, Key Laboratory of Cell Biology, National Health Commission of the PRC and Key Laboratory of Medical Cell Biology, Ministry of Education of the PRC, School of Life Sciences, China Medical University, Shenyang, Liaoning, China. lixiaodong@cmu.edu.cn., Li F; Department of Cell Biology, Key Laboratory of Cell Biology, National Health Commission of the PRC and Key Laboratory of Medical Cell Biology, Ministry of Education of the PRC, School of Life Sciences, China Medical University, Shenyang, Liaoning, China. lifeng@cmu.edu.cn. |
| Source: | Communications biology [Commun Biol] 2026 Jan 16; Vol. 9 (1), pp. 260. Date of Electronic Publication: 2026 Jan 16. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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