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Proteotranscriptomic Dissection of Breast Cancer T Cell States Identifies CD103+ Tfh-derived Cytotoxic Cells Linked to Immunotherapy Response.

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Title: Proteotranscriptomic Dissection of Breast Cancer T Cell States Identifies CD103+ Tfh-derived Cytotoxic Cells Linked to Immunotherapy Response.
Authors: Al-Eryani G; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Broad Clinical Labs, Burlington, MA, USA.; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia., Van Der Leij S; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia., Masle-Farquhar E; St Vincent's Clinical School, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.; Translational Genomics Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia., Chan CL; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; Current affiliation: The Westmead Institute for Medical Research, Westmead NSW 2145, Australia., Harvey K; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia., Wu SZ; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.; Current affiliation: Genentech Inc., South San Francisco, CA, USA., Roden D; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia., Wang T; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.; Biolegend, San Diego, CA, USA., Reeves J; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia., Yeung BZ; Biolegend, San Diego, CA, USA., Goodnow CC; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia., Ma CS; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia., Perou CM; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Hacohen N; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Broad Clinical Labs, Burlington, MA, USA., Al'Khafaji AM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Broad Clinical Labs, Burlington, MA, USA., Nilsson M; Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, 171 65 Solna, Sweden., Lundeberg J; Science for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology, Solna, Sweden., Batten M; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia., Junankar S; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.; Current Affiliation: Differentia Bio, South San Francisco, California, 94080, USA., Swarbrick A; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.; Lead contact.
Source: Research square [Res Sq] 2026 Jan 07. Date of Electronic Publication: 2026 Jan 07.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
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  Data: Proteotranscriptomic Dissection of Breast Cancer T Cell States Identifies CD103+ Tfh-derived Cytotoxic Cells Linked to Immunotherapy Response.
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  Data: <searchLink fieldCode="AU" term="%22Al-Eryani+G%22">Al-Eryani G</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Broad Clinical Labs, Burlington, MA, USA.; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Van+Der+Leij+S%22">Van Der Leij S</searchLink>; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Masle-Farquhar+E%22">Masle-Farquhar E</searchLink>; St Vincent's Clinical School, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.; Translational Genomics Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.<br /><searchLink fieldCode="AU" term="%22Chan+CL%22">Chan CL</searchLink>; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; Current affiliation: The Westmead Institute for Medical Research, Westmead NSW 2145, Australia.<br /><searchLink fieldCode="AU" term="%22Harvey+K%22">Harvey K</searchLink>; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Wu+SZ%22">Wu SZ</searchLink>; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.; Current affiliation: Genentech Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Roden+D%22">Roden D</searchLink>; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Wang+T%22">Wang T</searchLink>; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.; Biolegend, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Reeves+J%22">Reeves J</searchLink>; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Yeung+BZ%22">Yeung BZ</searchLink>; Biolegend, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Goodnow+CC%22">Goodnow CC</searchLink>; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Ma+CS%22">Ma CS</searchLink>; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Perou+CM%22">Perou CM</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Hacohen+N%22">Hacohen N</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Broad Clinical Labs, Burlington, MA, USA.<br /><searchLink fieldCode="AU" term="%22Al'Khafaji+AM%22">Al'Khafaji AM</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Broad Clinical Labs, Burlington, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nilsson+M%22">Nilsson M</searchLink>; Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, 171 65 Solna, Sweden.<br /><searchLink fieldCode="AU" term="%22Lundeberg+J%22">Lundeberg J</searchLink>; Science for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology, Solna, Sweden.<br /><searchLink fieldCode="AU" term="%22Batten+M%22">Batten M</searchLink>; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.<br /><searchLink fieldCode="AU" term="%22Junankar+S%22">Junankar S</searchLink>; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.; Current Affiliation: Differentia Bio, South San Francisco, California, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Swarbrick+A%22">Swarbrick A</searchLink>; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW 2052, Australia.; Lead contact.
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