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Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder.

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Title: Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder.
Authors: Sharew NT; Discipline of Psychiatry, School of Medicine, College of Health, Adelaide University, Adelaide, SA, Australia.; Asrat Woldeyes Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia., Clark SR; Discipline of Psychiatry, School of Medicine, College of Health, Adelaide University, Adelaide, SA, Australia., Hartmann S; Discipline of Psychiatry, School of Medicine, College of Health, Adelaide University, Adelaide, SA, Australia.; Orygen Youth Mental Health, Melbourne, Australia., Papiol S; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany., Heilbronner U; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Degenhardt F; Institute of Human Genetics, University Hospital, Faculty of Medicine, University of Bonn, Bonn, Germany.; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Duisburg-Essen, Rheinische Kliniken, Essen, Germany., Fullerton JM; Neuroscience Research Australia, Sydney, New South Wales, Australia.; School of Biomedical Sciences, University of New South Wales, Sydney, New South Wales, Australia., Hou L; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland., Shekhtman T; Department of Psychiatry, University of California San Diego, San Diego, California., Adli M; Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany., Akula N; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland., Akiyama K; Department of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Tochigi, Japan., Ardau R; Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy., Arias B; Unitat de Zoologia i Antropologia Biològica (Dpt. Biologia Evolutiva, Ecologia i Ciències Ambientals), Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona, Spain.; CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain., Tekola-Ayele F; Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA., Gallo C; Laboratorios de Investigación y Desarrollo, Facultad de Ciencias e Ingeniería, Universidad Peruana Cayetano Heredia, Lima, Perú., Hasler R; Department of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland., Richard-Lepouriel H; Department of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland., Perroud N; Department of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland., Backlund L; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Bhattacharjee AK; Department of Psychiatry, University of California San Diego, San Diego, California., Bellivier F; Institut National de la Santé et de la Recherche Médicale (INSERM) UMR-S 1144, Université Paris Cité, Département de Psychiatrie et de Médecine Addictologique, L'Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France., Benabarre A; Bipolar and Depressive Disorders Program, Institute of Neuroscience, Hospital Clínic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain., Bengesser S; Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria., Biernacka JM; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota.; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota., Birner A; Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria., Marie-Claire C; Institut National de la Santé et de la Recherche Médicale (INSERM) UMR-S 1144, Université Paris Cité, Département de Psychiatrie et de Médecine Addictologique, L'Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France.; Université Paris Cité, Inserm, Optimisation Thérapeutique en Neuropsychopharmacologie, Paris, France., Cervantes P; Neuromodulation Unit, McGill University Health Centre, Montreal, Quebec, Canada., Chen HC; Department of Psychiatry & Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan., Chillotti C; Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy., Cichon S; Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.; Institute of Neuroscience and Medicine, Research Center Jülich, Jülich, Germany., Cruceanu C; Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada., Czerski PM; Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznań, Poland., Dalkner N; Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria., Del Zompo M; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., DePaulo JR; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland., Étain B; Institut National de la Santé et de la Recherche Médicale (INSERM) UMR-S 1144, Université Paris Cité, Département de Psychiatrie et de Médecine Addictologique, L'Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France., Jamain S; Univ Paris Est Créteil, INSERM, IMRB, Translational Neuropsychiatry, Fondation FondaMental, Créteil, France., Falkai P; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany.; Max Planck Institute of Psychiatry, Munich, Germany.; German Center for Mental Health (DZPG), partner site Munich-Augsburg., Forstner AJ; Institute of Human Genetics, University Hospital, Faculty of Medicine, University of Bonn, Bonn, Germany.; Institute of Neuroscience and Medicine, Research Center Jülich, Jülich, Germany., Frisen L; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden., Frye MA; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota., Gard S; Pôle de Psychiatrie Générale Universitaire, Hôpital Charles Perrens, Bordeaux, France., Garnham JS; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada., Goes FS; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland., Grigoroiu-Serbanescu M; Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania., Fallgatter AJ; University Department of Psychiatry and Psychotherapy Tuebingen, University of Tübingen, Tübingen, Germany.; German Center for Mental Health (DZPG), partner site Tübingen, Germany., Stegmaier S; University Department of Psychiatry and Psychotherapy Tuebingen, University of Tübingen, Tübingen, Germany., Ethofer T; Department of General Psychiatry, University of Tübingen, Tübingen, Germany.; Department of Biomedical Resonance, University of Tübingen, Tübingen, Germany., Biere S; Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany., Petrova K; Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany., Schuster C; Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany., Adorjan K; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Department of Psychiatry and Psychotherapie, University of Bern, Bern, Switzerland., Budde M; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Heilbronner M; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Kalman JL; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany., Kohshour MO; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Reich-Erkelenz D; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Schaupp SK; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Schulte EC; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany.; Institute of Human Genetics, University Hospital, Faculty of Medicine, University of Bonn, Bonn, Germany.; German Center for Mental Health (DZPG), partner site Munich-Augsburg.; Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Senner F; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany., Vogl T; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Anghelescu IG; Department of Psychiatry and Psychotherapy, Mental Health Institute Berlin, Berlin, Germany., Arolt V; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Dannlowski U; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Dietrich DE; AMEOS Clinical Center Hildesheim, Hildesheim, Germany.; Center for Systems Neuroscience, Hannover, Germany., Figge C; Karl-Jaspers Clinic, European Medical School Oldenburg-Groningen, Oldenburg, Germany., Jäger M; Department of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, Germany., Lang FU; Department of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, Germany., Juckel G; Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany., Konrad C; Department of Psychiatry and Psychotherapy, Agaplesion Diakonieklinikum, Rotenburg, Germany., Reimer J; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Psychiatry, Health North Hospital Group, Bremen, Germany., Schmauß M; Department of Psychiatry and Psychotherapy, Bezirkskrankenhaus Augsburg, Augsburg, Germany., Schmitt A; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany.; Max Planck Institute of Psychiatry, Munich, Germany.; Laboratory of Neuroscience, Institute of Psychiatry, University of Sao Paulo, São Paulo, Brazil., Spitzer C; Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Rostock, Rostock, Germany., von Hagen M; Clinic for Psychiatry and Psychotherapy, Clinical Center Werra-Meißner, Eschwege, Germany., Wiltfang J; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.; German Center for Neurodegenerative Diseases, University of Göttingen, Göttingen, Germany., Zimmermann J; Psychiatrieverbund Oldenburger Land GmbH, Karl-Jaspers-Klinik, Bad Zwischenahn, Germany., Andlauer TFM; Department of Neurology, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Fischer A; German Center for Neurodegenerative Diseases, University of Göttingen, Göttingen, Germany., Bermpohl F; Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany., Ritter P; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Faculty of Medicine, TUD Dresden University of Technology, Germany., Matura S; Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany., Gryaznova A; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Falkenberg I; Department of Psychiatry and Psychotherapy, Philipps-University, Marburg, Germany., Yildiz C; Department of Psychiatry and Psychotherapy, Philipps-University, Marburg, Germany., Kircher T; Department of Psychiatry and Psychotherapy, Philipps-University, Marburg, Germany., Schmidt J; Institute for Medical Informatics, University Medical Center Göttingen, Göttingen, Germany., Koch M; Institute for Medical Informatics, University Medical Center Göttingen, Göttingen, Germany., Gade K; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany., Trost S; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany., Haussleiter IS; Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany., Lambert M; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Rohenkohl AC; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kraft V; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Grof P; Mood Disorders Center of Ottawa, Ottawa, Ontario, Canada., Hashimoto R; Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan., Hauser J; Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznań, Poland., Herms S; Institute of Human Genetics, University Hospital, Faculty of Medicine, University of Bonn, Bonn, Germany.; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland., Hoffmann P; Institute of Human Genetics, University Hospital, Faculty of Medicine, University of Bonn, Bonn, Germany.; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland., Jiménez E; Bipolar and Depressive Disorders Program, Institute of Neuroscience, Hospital Clínic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain., Kahn JP; Service de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy, Université de Lorraine, Nancy, France., Kassem L; Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany., Kuo PH; Department of Public Health & Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan., Kato T; Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Saitama, Japan., Kelsoe J; Department of Psychiatry, University of California San Diego, San Diego, California., Kittel-Schneider S; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.; Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, University Hospital of Würzburg, Würzburg, Germany., Ferensztajn-Rochowiak E; Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznań, Poland., König B; Department of Psychiatry and Psychotherapeutic Medicine, Landesklinikum Neunkirchen, Neunkirchen, Austria., Kusumi I; Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan., Laje G; Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany., Landén M; Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Lavebratt C; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Leboyer M; Inserm U955, Translational Psychiatry Laboratory, Université Paris-Est-Créteil, Department of Psychiatry and Addictology of Mondor University Hospital, AP-HP, Fondation FondaMental, Créteil, France., Leckband SG; Office of Mental Health, VA San Diego Healthcare System, San Diego, California., Tortorella A; Department of Psychiatry, University of Perugia, Perugia, Italy., Manchia M; Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.; Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada., Martinsson L; Department of Clinical Neurosciences, Karolinska Institute, Stockholm, Sweden., McCarthy MJ; Department of Psychiatry, University of California San Diego, San Diego, California.; Department of Psychiatry, VA San Diego Healthcare System, San Diego, California., McElroy SL; Department of Psychiatry, Lindner Center of Hope, University of Cincinnati, Mason, Ohio., Colom F; Mental Health Research Group, Hospital del Mar Medical Research Institute (IMIM)-Hospital del Mar, Barcelona, Catalonia, Spain.; Department of Genetics, Microbiology and Statistics, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain., Millischer V; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.; Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria., Mitjans M; CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain.; Department of Genetics, Microbiology and Statistics, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.; Institut de Biomedicina de la Universität de Barcelona, Barcelona, Spain.; Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain., Mondimore FM; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland., Monteleone P; Neurosciences Section, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Salerno, Italy.; Department of Psychiatry, University of Campania 'Luigi Vanvitelli', Naples, Italy., Nievergelt CM; Department of Psychiatry, University of California San Diego, San Diego, California., Nöthen MM; Institute of Human Genetics, University Hospital, Faculty of Medicine, University of Bonn, Bonn, Germany., Novák T; National Institute of Mental Health, Klecany, Czechia., O'Donovan C; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada., Ozaki N; Department of Psychiatry & Department of Child and Adolescent Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan., Pfennig A; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Faculty of Medicine, TUD Dresden University of Technology, Germany., Pisanu C; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Potash JB; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland., Reif A; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany., Reininghaus E; Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria., Rouleau GA; Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada., Rybakowski JK; Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznań, Poland., Schalling M; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Schofield PR; Neuroscience Research Australia, Sydney, New South Wales, Australia.; School of Biomedical Sciences, University of New South Wales, Sydney, New South Wales, Australia., Schweizer BW; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland., Severino G; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Shilling PD; Department of Psychiatry, University of California San Diego, San Diego, California., Shimoda K; Department of Psychiatry, Dokkyo Medical University School of Medicine, Tochigi, Japan., Simhandl C; Bipolar Center Wiener Neustadt, Sigmund Freud University, Medical Faculty, Vienna, Austria., Slaney CM; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada., Squassina A; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Stamm T; Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.; Department of Clinical Psychiatry and Psychotherapy, Brandenburg Medical School, Brandenburg, Germany., Stopkova P; National Institute of Mental Health, Klecany, Czechia., Maj M; Department of Psychiatry, University of Campania 'Luigi Vanvitelli', Naples, Italy., Turecki G; Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada., Vieta E; Bipolar and Depressive Disorders Program, Institute of Neuroscience, Hospital Clínic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain., Veeh J; Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden., Viswanath B; Department of Psychiatry, National Institute of Mental Health and Neuroscience, Bangalore, India., Witt SH; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Wright A; Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales Sydney, New South Wales, Australia., Zandi PP; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Mitchell PB; Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales Sydney, New South Wales, Australia., Bauer M; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Faculty of Medicine, TUD Dresden University of Technology, Germany., Alda M; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.; National Institute of Mental Health, Klecany, Czechia., Rietschel M; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., McMahon FJ; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland., Schulze TG; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.; German Center for Mental Health (DZPG), partner site Munich-Augsburg.; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.; Department of Psychiatry and Behavioral Sciences, Norton College of Medicine, SUNY Upstate Medical University, Syracuse, New York.; Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University Göttingen, Göttingen, Germany., Baune BT; Department of Psychiatry and Psychotherapy, University of Münster, Münster, Germany.; Department of Psychiatry, Melbourne Medical School, University of Melbourne, Parkville, Victoria, Australia.; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia., Schubert KO; Discipline of Psychiatry, School of Medicine, College of Health, Adelaide University, Adelaide, SA, Australia.; Northern Adelaide Local Health Network, Mental Health Services, Adelaide, South Australia, Australia., Amare AT; Discipline of Psychiatry, School of Medicine, College of Health, Adelaide University, Adelaide, SA, Australia.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2026 Jan 05. Date of Electronic Publication: 2026 Jan 05.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder.
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  Data: <searchLink fieldCode="AU" term="%22Sharew+NT%22">Sharew NT</searchLink>; Discipline of Psychiatry, School of Medicine, College of Health, Adelaide University, Adelaide, SA, Australia.; Asrat Woldeyes Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Clark+SR%22">Clark SR</searchLink>; Discipline of Psychiatry, School of Medicine, College of Health, Adelaide University, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Hartmann+S%22">Hartmann S</searchLink>; Discipline of Psychiatry, School of Medicine, College of Health, Adelaide University, Adelaide, SA, Australia.; Orygen Youth Mental Health, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Papiol+S%22">Papiol S</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Heilbronner+U%22">Heilbronner U</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Degenhardt+F%22">Degenhardt F</searchLink>; Institute of Human Genetics, University Hospital, Faculty of Medicine, University of Bonn, Bonn, Germany.; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Duisburg-Essen, Rheinische Kliniken, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Fullerton+JM%22">Fullerton JM</searchLink>; Neuroscience Research Australia, Sydney, New South Wales, Australia.; School of Biomedical Sciences, University of New South Wales, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Hou+L%22">Hou L</searchLink>; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Shekhtman+T%22">Shekhtman T</searchLink>; Department of Psychiatry, University of California San Diego, San Diego, California.<br /><searchLink fieldCode="AU" term="%22Adli+M%22">Adli M</searchLink>; Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Akula+N%22">Akula N</searchLink>; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Akiyama+K%22">Akiyama K</searchLink>; Department of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Tochigi, Japan.<br /><searchLink fieldCode="AU" term="%22Ardau+R%22">Ardau R</searchLink>; Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Arias+B%22">Arias B</searchLink>; Unitat de Zoologia i Antropologia Biològica (Dpt. Biologia Evolutiva, Ecologia i Ciències Ambientals), Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona, Spain.; CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Tekola-Ayele+F%22">Tekola-Ayele F</searchLink>; Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Gallo+C%22">Gallo C</searchLink>; Laboratorios de Investigación y Desarrollo, Facultad de Ciencias e Ingeniería, Universidad Peruana Cayetano Heredia, Lima, Perú.<br /><searchLink fieldCode="AU" term="%22Hasler+R%22">Hasler R</searchLink>; Department of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Richard-Lepouriel+H%22">Richard-Lepouriel H</searchLink>; Department of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Perroud+N%22">Perroud N</searchLink>; Department of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Backlund+L%22">Backlund L</searchLink>; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Bhattacharjee+AK%22">Bhattacharjee AK</searchLink>; Department of Psychiatry, University of California San Diego, San Diego, California.<br /><searchLink fieldCode="AU" term="%22Bellivier+F%22">Bellivier F</searchLink>; Institut National de la Santé et de la Recherche Médicale (INSERM) UMR-S 1144, Université Paris Cité, Département de Psychiatrie et de Médecine Addictologique, L'Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France.<br /><searchLink fieldCode="AU" term="%22Benabarre+A%22">Benabarre A</searchLink>; Bipolar and Depressive Disorders Program, Institute of Neuroscience, Hospital Clínic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Bengesser+S%22">Bengesser S</searchLink>; Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Biernacka+JM%22">Biernacka JM</searchLink>; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota.; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Birner+A%22">Birner A</searchLink>; Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Marie-Claire+C%22">Marie-Claire C</searchLink>; Institut National de la Santé et de la Recherche Médicale (INSERM) UMR-S 1144, Université Paris Cité, Département de Psychiatrie et de Médecine Addictologique, L'Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France.; Université Paris Cité, Inserm, Optimisation Thérapeutique en Neuropsychopharmacologie, Paris, France.<br /><searchLink fieldCode="AU" term="%22Cervantes+P%22">Cervantes P</searchLink>; Neuromodulation Unit, McGill University Health Centre, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Chen+HC%22">Chen HC</searchLink>; Department of Psychiatry & Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chillotti+C%22">Chillotti C</searchLink>; Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Cichon+S%22">Cichon S</searchLink>; Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.; Institute of Neuroscience and Medicine, Research Center Jülich, Jülich, Germany.<br /><searchLink fieldCode="AU" term="%22Cruceanu+C%22">Cruceanu C</searchLink>; Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Czerski+PM%22">Czerski PM</searchLink>; Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznań, Poland.<br /><searchLink fieldCode="AU" term="%22Dalkner+N%22">Dalkner N</searchLink>; Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Del+Zompo+M%22">Del Zompo M</searchLink>; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22DePaulo+JR%22">DePaulo JR</searchLink>; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Étain+B%22">Étain B</searchLink>; Institut National de la Santé et de la Recherche Médicale (INSERM) UMR-S 1144, Université Paris Cité, Département de Psychiatrie et de Médecine Addictologique, L'Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France.<br /><searchLink fieldCode="AU" term="%22Jamain+S%22">Jamain S</searchLink>; Univ Paris Est Créteil, INSERM, IMRB, Translational Neuropsychiatry, Fondation FondaMental, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Falkai+P%22">Falkai P</searchLink>; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany.; Max Planck Institute of Psychiatry, Munich, Germany.; German Center for Mental Health (DZPG), partner site Munich-Augsburg.<br /><searchLink fieldCode="AU" term="%22Forstner+AJ%22">Forstner AJ</searchLink>; Institute of Human Genetics, University Hospital, Faculty of Medicine, University of Bonn, Bonn, Germany.; Institute of Neuroscience and Medicine, Research Center Jülich, Jülich, Germany.<br /><searchLink fieldCode="AU" term="%22Frisen+L%22">Frisen L</searchLink>; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Frye+MA%22">Frye MA</searchLink>; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Gard+S%22">Gard S</searchLink>; Pôle de Psychiatrie Générale Universitaire, Hôpital Charles Perrens, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Garnham+JS%22">Garnham JS</searchLink>; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Goes+FS%22">Goes FS</searchLink>; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Grigoroiu-Serbanescu+M%22">Grigoroiu-Serbanescu M</searchLink>; Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.<br /><searchLink fieldCode="AU" term="%22Fallgatter+AJ%22">Fallgatter AJ</searchLink>; University Department of Psychiatry and Psychotherapy Tuebingen, University of Tübingen, Tübingen, Germany.; German Center for Mental Health (DZPG), partner site Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Stegmaier+S%22">Stegmaier S</searchLink>; University Department of Psychiatry and Psychotherapy Tuebingen, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Ethofer+T%22">Ethofer T</searchLink>; Department of General Psychiatry, University of Tübingen, Tübingen, Germany.; Department of Biomedical Resonance, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Biere+S%22">Biere S</searchLink>; Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Petrova+K%22">Petrova K</searchLink>; Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Schuster+C%22">Schuster C</searchLink>; Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Adorjan+K%22">Adorjan K</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Department of Psychiatry and Psychotherapie, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Budde+M%22">Budde M</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Heilbronner+M%22">Heilbronner M</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kalman+JL%22">Kalman JL</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kohshour+MO%22">Kohshour MO</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.<br /><searchLink fieldCode="AU" term="%22Reich-Erkelenz+D%22">Reich-Erkelenz D</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Schaupp+SK%22">Schaupp SK</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Schulte+EC%22">Schulte EC</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany.; Institute of Human Genetics, University Hospital, Faculty of Medicine, University of Bonn, Bonn, Germany.; German Center for Mental Health (DZPG), partner site Munich-Augsburg.; Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.<br /><searchLink fieldCode="AU" term="%22Senner+F%22">Senner F</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Vogl+T%22">Vogl T</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Anghelescu+IG%22">Anghelescu IG</searchLink>; Department of Psychiatry and Psychotherapy, Mental Health Institute Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Arolt+V%22">Arolt V</searchLink>; Institute for Translational Psychiatry, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Dannlowski+U%22">Dannlowski U</searchLink>; Institute for Translational Psychiatry, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Dietrich+DE%22">Dietrich DE</searchLink>; AMEOS Clinical Center Hildesheim, Hildesheim, Germany.; Center for Systems Neuroscience, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Figge+C%22">Figge C</searchLink>; Karl-Jaspers Clinic, European Medical School Oldenburg-Groningen, Oldenburg, Germany.<br /><searchLink fieldCode="AU" term="%22Jäger+M%22">Jäger M</searchLink>; Department of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Lang+FU%22">Lang FU</searchLink>; Department of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Juckel+G%22">Juckel G</searchLink>; Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Konrad+C%22">Konrad C</searchLink>; Department of Psychiatry and Psychotherapy, Agaplesion Diakonieklinikum, Rotenburg, Germany.<br /><searchLink fieldCode="AU" term="%22Reimer+J%22">Reimer J</searchLink>; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Psychiatry, Health North Hospital Group, Bremen, Germany.<br /><searchLink fieldCode="AU" term="%22Schmauß+M%22">Schmauß M</searchLink>; Department of Psychiatry and Psychotherapy, Bezirkskrankenhaus Augsburg, Augsburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schmitt+A%22">Schmitt A</searchLink>; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany.; Max Planck Institute of Psychiatry, Munich, Germany.; Laboratory of Neuroscience, Institute of Psychiatry, University of Sao Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Spitzer+C%22">Spitzer C</searchLink>; Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Rostock, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22von+Hagen+M%22">von Hagen M</searchLink>; Clinic for Psychiatry and Psychotherapy, Clinical Center Werra-Meißner, Eschwege, Germany.<br /><searchLink fieldCode="AU" term="%22Wiltfang+J%22">Wiltfang J</searchLink>; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.; German Center for Neurodegenerative Diseases, University of Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Zimmermann+J%22">Zimmermann J</searchLink>; Psychiatrieverbund Oldenburger Land GmbH, Karl-Jaspers-Klinik, Bad Zwischenahn, Germany.<br /><searchLink fieldCode="AU" term="%22Andlauer+TFM%22">Andlauer TFM</searchLink>; Department of Neurology, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Fischer+A%22">Fischer A</searchLink>; German Center for Neurodegenerative Diseases, University of Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Bermpohl+F%22">Bermpohl F</searchLink>; Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Ritter+P%22">Ritter P</searchLink>; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Faculty of Medicine, TUD Dresden University of Technology, Germany.<br /><searchLink fieldCode="AU" term="%22Matura+S%22">Matura S</searchLink>; Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Gryaznova+A%22">Gryaznova A</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Falkenberg+I%22">Falkenberg I</searchLink>; Department of Psychiatry and Psychotherapy, Philipps-University, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Yildiz+C%22">Yildiz C</searchLink>; Department of Psychiatry and Psychotherapy, Philipps-University, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kircher+T%22">Kircher T</searchLink>; Department of Psychiatry and Psychotherapy, Philipps-University, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schmidt+J%22">Schmidt J</searchLink>; Institute for Medical Informatics, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Koch+M%22">Koch M</searchLink>; Institute for Medical Informatics, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Gade+K%22">Gade K</searchLink>; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Trost+S%22">Trost S</searchLink>; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Haussleiter+IS%22">Haussleiter IS</searchLink>; Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Lambert+M%22">Lambert M</searchLink>; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rohenkohl+AC%22">Rohenkohl AC</searchLink>; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kraft+V%22">Kraft V</searchLink>; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Grof+P%22">Grof P</searchLink>; Mood Disorders Center of Ottawa, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Hashimoto+R%22">Hashimoto R</searchLink>; Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hauser+J%22">Hauser J</searchLink>; Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznań, Poland.<br /><searchLink fieldCode="AU" term="%22Herms+S%22">Herms S</searchLink>; Institute of Human Genetics, University Hospital, Faculty of Medicine, University of Bonn, Bonn, Germany.; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hoffmann+P%22">Hoffmann P</searchLink>; Institute of Human Genetics, University Hospital, Faculty of Medicine, University of Bonn, Bonn, Germany.; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Jiménez+E%22">Jiménez E</searchLink>; Bipolar and Depressive Disorders Program, Institute of Neuroscience, Hospital Clínic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Kahn+JP%22">Kahn JP</searchLink>; Service de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy, Université de Lorraine, Nancy, France.<br /><searchLink fieldCode="AU" term="%22Kassem+L%22">Kassem L</searchLink>; Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Kuo+PH%22">Kuo PH</searchLink>; Department of Public Health & Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kato+T%22">Kato T</searchLink>; Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Kelsoe+J%22">Kelsoe J</searchLink>; Department of Psychiatry, University of California San Diego, San Diego, California.<br /><searchLink fieldCode="AU" term="%22Kittel-Schneider+S%22">Kittel-Schneider S</searchLink>; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.; Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, University Hospital of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Ferensztajn-Rochowiak+E%22">Ferensztajn-Rochowiak E</searchLink>; Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznań, Poland.<br /><searchLink fieldCode="AU" term="%22König+B%22">König B</searchLink>; Department of Psychiatry and Psychotherapeutic Medicine, Landesklinikum Neunkirchen, Neunkirchen, Austria.<br /><searchLink fieldCode="AU" term="%22Kusumi+I%22">Kusumi I</searchLink>; Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Laje+G%22">Laje G</searchLink>; Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Landén+M%22">Landén M</searchLink>; Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Lavebratt+C%22">Lavebratt C</searchLink>; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Leboyer+M%22">Leboyer M</searchLink>; Inserm U955, Translational Psychiatry Laboratory, Université Paris-Est-Créteil, Department of Psychiatry and Addictology of Mondor University Hospital, AP-HP, Fondation FondaMental, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Leckband+SG%22">Leckband SG</searchLink>; Office of Mental Health, VA San Diego Healthcare System, San Diego, California.<br /><searchLink fieldCode="AU" term="%22Tortorella+A%22">Tortorella A</searchLink>; Department of Psychiatry, University of Perugia, Perugia, Italy.<br /><searchLink fieldCode="AU" term="%22Manchia+M%22">Manchia M</searchLink>; Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.; Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Martinsson+L%22">Martinsson L</searchLink>; Department of Clinical Neurosciences, Karolinska Institute, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22McCarthy+MJ%22">McCarthy MJ</searchLink>; Department of Psychiatry, University of California San Diego, San Diego, California.; Department of Psychiatry, VA San Diego Healthcare System, San Diego, California.<br /><searchLink fieldCode="AU" term="%22McElroy+SL%22">McElroy SL</searchLink>; Department of Psychiatry, Lindner Center of Hope, University of Cincinnati, Mason, Ohio.<br /><searchLink fieldCode="AU" term="%22Colom+F%22">Colom F</searchLink>; Mental Health Research Group, Hospital del Mar Medical Research Institute (IMIM)-Hospital del Mar, Barcelona, Catalonia, Spain.; Department of Genetics, Microbiology and Statistics, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Millischer+V%22">Millischer V</searchLink>; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.; Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Mitjans+M%22">Mitjans M</searchLink>; CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain.; Department of Genetics, Microbiology and Statistics, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.; Institut de Biomedicina de la Universität de Barcelona, Barcelona, Spain.; Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain.<br /><searchLink fieldCode="AU" term="%22Mondimore+FM%22">Mondimore FM</searchLink>; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Monteleone+P%22">Monteleone P</searchLink>; Neurosciences Section, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Salerno, Italy.; Department of Psychiatry, University of Campania 'Luigi Vanvitelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Nievergelt+CM%22">Nievergelt CM</searchLink>; Department of Psychiatry, University of California San Diego, San Diego, California.<br /><searchLink fieldCode="AU" term="%22Nöthen+MM%22">Nöthen MM</searchLink>; Institute of Human Genetics, University Hospital, Faculty of Medicine, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Novák+T%22">Novák T</searchLink>; National Institute of Mental Health, Klecany, Czechia.<br /><searchLink fieldCode="AU" term="%22O'Donovan+C%22">O'Donovan C</searchLink>; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Ozaki+N%22">Ozaki N</searchLink>; Department of Psychiatry & Department of Child and Adolescent Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Pfennig+A%22">Pfennig A</searchLink>; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Faculty of Medicine, TUD Dresden University of Technology, Germany.<br /><searchLink fieldCode="AU" term="%22Pisanu+C%22">Pisanu C</searchLink>; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Potash+JB%22">Potash JB</searchLink>; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Reif+A%22">Reif A</searchLink>; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Reininghaus+E%22">Reininghaus E</searchLink>; Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Rouleau+GA%22">Rouleau GA</searchLink>; Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Rybakowski+JK%22">Rybakowski JK</searchLink>; Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznań, Poland.<br /><searchLink fieldCode="AU" term="%22Schalling+M%22">Schalling M</searchLink>; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Schofield+PR%22">Schofield PR</searchLink>; Neuroscience Research Australia, Sydney, New South Wales, Australia.; School of Biomedical Sciences, University of New South Wales, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Schweizer+BW%22">Schweizer BW</searchLink>; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Severino+G%22">Severino G</searchLink>; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Shilling+PD%22">Shilling PD</searchLink>; Department of Psychiatry, University of California San Diego, San Diego, California.<br /><searchLink fieldCode="AU" term="%22Shimoda+K%22">Shimoda K</searchLink>; Department of Psychiatry, Dokkyo Medical University School of Medicine, Tochigi, Japan.<br /><searchLink fieldCode="AU" term="%22Simhandl+C%22">Simhandl C</searchLink>; Bipolar Center Wiener Neustadt, Sigmund Freud University, Medical Faculty, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Slaney+CM%22">Slaney CM</searchLink>; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Squassina+A%22">Squassina A</searchLink>; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Stamm+T%22">Stamm T</searchLink>; Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.; Department of Clinical Psychiatry and Psychotherapy, Brandenburg Medical School, Brandenburg, Germany.<br /><searchLink fieldCode="AU" term="%22Stopkova+P%22">Stopkova P</searchLink>; National Institute of Mental Health, Klecany, Czechia.<br /><searchLink fieldCode="AU" term="%22Maj+M%22">Maj M</searchLink>; Department of Psychiatry, University of Campania 'Luigi Vanvitelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Turecki+G%22">Turecki G</searchLink>; Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Vieta+E%22">Vieta E</searchLink>; Bipolar and Depressive Disorders Program, Institute of Neuroscience, Hospital Clínic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Veeh+J%22">Veeh J</searchLink>; Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Viswanath+B%22">Viswanath B</searchLink>; Department of Psychiatry, National Institute of Mental Health and Neuroscience, Bangalore, India.<br /><searchLink fieldCode="AU" term="%22Witt+SH%22">Witt SH</searchLink>; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Wright+A%22">Wright A</searchLink>; Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Zandi+PP%22">Zandi PP</searchLink>; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Mitchell+PB%22">Mitchell PB</searchLink>; Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Bauer+M%22">Bauer M</searchLink>; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Faculty of Medicine, TUD Dresden University of Technology, Germany.<br /><searchLink fieldCode="AU" term="%22Alda+M%22">Alda M</searchLink>; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.; National Institute of Mental Health, Klecany, Czechia.<br /><searchLink fieldCode="AU" term="%22Rietschel+M%22">Rietschel M</searchLink>; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22McMahon+FJ%22">McMahon FJ</searchLink>; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Schulze+TG%22">Schulze TG</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.; German Center for Mental Health (DZPG), partner site Munich-Augsburg.; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.; Department of Psychiatry and Behavioral Sciences, Norton College of Medicine, SUNY Upstate Medical University, Syracuse, New York.; Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Baune+BT%22">Baune BT</searchLink>; Department of Psychiatry and Psychotherapy, University of Münster, Münster, Germany.; Department of Psychiatry, Melbourne Medical School, University of Melbourne, Parkville, Victoria, Australia.; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Schubert+KO%22">Schubert KO</searchLink>; Discipline of Psychiatry, School of Medicine, College of Health, Adelaide University, Adelaide, SA, Australia.; Northern Adelaide Local Health Network, Mental Health Services, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Amare+AT%22">Amare AT</searchLink>; Discipline of Psychiatry, School of Medicine, College of Health, Adelaide University, Adelaide, SA, Australia.
– Name: TitleSource
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  Data: <searchLink fieldCode="JN" term="%22101767986%22">MedRxiv : the preprint server for health sciences</searchLink> [medRxiv] 2026 Jan 05. <i>Date of Electronic Publication: </i>2026 Jan 05.
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  Data: Journal Article; Preprint
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  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101767986 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>NLM ISO Abbreviation: </i>medRxiv <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41542698
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      – Type: doi
        Value: 10.64898/2026.01.01.25343187
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      – Code: eng
        Text: English
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      – TitleFull: Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder.
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            NameFull: McElroy SL
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          Name:
            NameFull: Colom F
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          Name:
            NameFull: Millischer V
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            NameFull: Mitjans M
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            NameFull: Mondimore FM
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            NameFull: Monteleone P
      – PersonEntity:
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            NameFull: Nievergelt CM
      – PersonEntity:
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            NameFull: Nöthen MM
      – PersonEntity:
          Name:
            NameFull: Novák T
      – PersonEntity:
          Name:
            NameFull: O'Donovan C
      – PersonEntity:
          Name:
            NameFull: Ozaki N
      – PersonEntity:
          Name:
            NameFull: Pfennig A
      – PersonEntity:
          Name:
            NameFull: Pisanu C
      – PersonEntity:
          Name:
            NameFull: Potash JB
      – PersonEntity:
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            NameFull: Reif A
      – PersonEntity:
          Name:
            NameFull: Reininghaus E
      – PersonEntity:
          Name:
            NameFull: Rouleau GA
      – PersonEntity:
          Name:
            NameFull: Rybakowski JK
      – PersonEntity:
          Name:
            NameFull: Schalling M
      – PersonEntity:
          Name:
            NameFull: Schofield PR
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          Name:
            NameFull: Schweizer BW
      – PersonEntity:
          Name:
            NameFull: Severino G
      – PersonEntity:
          Name:
            NameFull: Shilling PD
      – PersonEntity:
          Name:
            NameFull: Shimoda K
      – PersonEntity:
          Name:
            NameFull: Simhandl C
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          Name:
            NameFull: Slaney CM
      – PersonEntity:
          Name:
            NameFull: Squassina A
      – PersonEntity:
          Name:
            NameFull: Stamm T
      – PersonEntity:
          Name:
            NameFull: Stopkova P
      – PersonEntity:
          Name:
            NameFull: Maj M
      – PersonEntity:
          Name:
            NameFull: Turecki G
      – PersonEntity:
          Name:
            NameFull: Vieta E
      – PersonEntity:
          Name:
            NameFull: Veeh J
      – PersonEntity:
          Name:
            NameFull: Viswanath B
      – PersonEntity:
          Name:
            NameFull: Witt SH
      – PersonEntity:
          Name:
            NameFull: Wright A
      – PersonEntity:
          Name:
            NameFull: Zandi PP
      – PersonEntity:
          Name:
            NameFull: Mitchell PB
      – PersonEntity:
          Name:
            NameFull: Bauer M
      – PersonEntity:
          Name:
            NameFull: Alda M
      – PersonEntity:
          Name:
            NameFull: Rietschel M
      – PersonEntity:
          Name:
            NameFull: McMahon FJ
      – PersonEntity:
          Name:
            NameFull: Schulze TG
      – PersonEntity:
          Name:
            NameFull: Baune BT
      – PersonEntity:
          Name:
            NameFull: Schubert KO
      – PersonEntity:
          Name:
            NameFull: Amare AT
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 05
              M: 01
              Text: 2026 Jan 05
              Type: published
              Y: 2026
          Titles:
            – TitleFull: MedRxiv : the preprint server for health sciences
              Type: main
ResultId 1