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Extracellular vesicle-derived miRNA-182-5p educates macrophages towards an immunosuppressive phenotype in pancreatic cancer.

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Title: Extracellular vesicle-derived miRNA-182-5p educates macrophages towards an immunosuppressive phenotype in pancreatic cancer.
Authors: Singh B; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Gaur P; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.; Center for Advanced Immunotherapy Research, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Bose P; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Zhang Y; Department of Biochemistry, Molecular and Cellular Biology, Georgetown University, Georgetown University Medical Center, Washington, DC, USA., Li Y; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Zhang Z; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Kandhavelu J; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Klotzbier W; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Jayatilake M; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Bansal S; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Farhan M; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Deol S; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Banerjee PP; Department of Biochemistry, Molecular and Cellular Biology, Georgetown University, Georgetown University Medical Center, Washington, DC, USA., Unger K; Department of Radiation Medicine, MedStar Georgetown University Hospital, Washington, DC, USA., Gupta S; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.; Center for Advanced Immunotherapy Research, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Verma V; The Hormel Institute, University of Minnesota, Austin, MN, USA.; Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA., Cheema AK; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA. akc27@georgetown.edu.; Department of Biochemistry, Molecular and Cellular Biology, Georgetown University, Georgetown University Medical Center, Washington, DC, USA. akc27@georgetown.edu.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Jan 16; Vol. 11 (1), pp. 31. Date of Electronic Publication: 2026 Jan 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
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  Data: Extracellular vesicle-derived miRNA-182-5p educates macrophages towards an immunosuppressive phenotype in pancreatic cancer.
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  Data: <searchLink fieldCode="AU" term="%22Singh+B%22">Singh B</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Gaur+P%22">Gaur P</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.; Center for Advanced Immunotherapy Research, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Bose+P%22">Bose P</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Biochemistry, Molecular and Cellular Biology, Georgetown University, Georgetown University Medical Center, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Kandhavelu+J%22">Kandhavelu J</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Klotzbier+W%22">Klotzbier W</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Jayatilake+M%22">Jayatilake M</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Bansal+S%22">Bansal S</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Farhan+M%22">Farhan M</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Deol+S%22">Deol S</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Banerjee+PP%22">Banerjee PP</searchLink>; Department of Biochemistry, Molecular and Cellular Biology, Georgetown University, Georgetown University Medical Center, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Unger+K%22">Unger K</searchLink>; Department of Radiation Medicine, MedStar Georgetown University Hospital, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Gupta+S%22">Gupta S</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.; Center for Advanced Immunotherapy Research, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Verma+V%22">Verma V</searchLink>; The Hormel Institute, University of Minnesota, Austin, MN, USA.; Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Cheema+AK%22">Cheema AK</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA. akc27@georgetown.edu.; Department of Biochemistry, Molecular and Cellular Biology, Georgetown University, Georgetown University Medical Center, Washington, DC, USA. akc27@georgetown.edu.
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