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Optimal murine CD4+ T cell priming by mRNA-lipid nanoparticle vaccines requires endogenous antigen processing.

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Title: Optimal murine CD4+ T cell priming by mRNA-lipid nanoparticle vaccines requires endogenous antigen processing.
Authors: Rood JE; Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA. ROODJ@chop.edu., Yoon SK; School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Heard MK; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Bristol Myers Squibb, Lawrenceville, NJ, USA., Carro SD; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Hedgepeth EJ; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA., O'Mara ME; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Jefferson College of Life Sciences, Thomas Jefferson University, Philadelphia, PA, USA., Hogan MJ; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA., Le N; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Drexel University College of Medicine at Tower Health, Wyomissing, PA, USA., Muramatsu H; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lam K; Genevant Sciences Corporation, Vancouver, British Columbia, Canada., Schreiner P; Genevant Sciences Corporation, Vancouver, British Columbia, Canada., Kasden C; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Stedman HH; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Langlois RA; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA., Heyes J; Genevant Sciences Corporation, Vancouver, British Columbia, Canada., Pardi N; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Eisenlohr LC; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA. eisenlc@pennmedicine.upenn.edu.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. eisenlc@pennmedicine.upenn.edu.
Source: Nature communications [Nat Commun] 2026 Jan 16; Vol. 17 (1), pp. 1327. Date of Electronic Publication: 2026 Jan 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Optimal murine CD4<superscript>+</superscript> T cell priming by mRNA-lipid nanoparticle vaccines requires endogenous antigen processing.
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  Data: <searchLink fieldCode="AU" term="%22Rood+JE%22">Rood JE</searchLink>; Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA. ROODJ@chop.edu.<br /><searchLink fieldCode="AU" term="%22Yoon+SK%22">Yoon SK</searchLink>; School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Heard+MK%22">Heard MK</searchLink>; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Bristol Myers Squibb, Lawrenceville, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Carro+SD%22">Carro SD</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hedgepeth+EJ%22">Hedgepeth EJ</searchLink>; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22O'Mara+ME%22">O'Mara ME</searchLink>; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Jefferson College of Life Sciences, Thomas Jefferson University, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hogan+MJ%22">Hogan MJ</searchLink>; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Le+N%22">Le N</searchLink>; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Drexel University College of Medicine at Tower Health, Wyomissing, PA, USA.<br /><searchLink fieldCode="AU" term="%22Muramatsu+H%22">Muramatsu H</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lam+K%22">Lam K</searchLink>; Genevant Sciences Corporation, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Schreiner+P%22">Schreiner P</searchLink>; Genevant Sciences Corporation, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Kasden+C%22">Kasden C</searchLink>; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Stedman+HH%22">Stedman HH</searchLink>; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Langlois+RA%22">Langlois RA</searchLink>; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Heyes+J%22">Heyes J</searchLink>; Genevant Sciences Corporation, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Pardi+N%22">Pardi N</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Eisenlohr+LC%22">Eisenlohr LC</searchLink>; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA. eisenlc@pennmedicine.upenn.edu.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. eisenlc@pennmedicine.upenn.edu.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Jan 16; Vol. 17 (1), pp. 1327. <i>Date of Electronic Publication: </i>2026 Jan 16.
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