Optimal murine CD4+ T cell priming by mRNA-lipid nanoparticle vaccines requires endogenous antigen processing.
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| Title: | Optimal murine CD4+ T cell priming by mRNA-lipid nanoparticle vaccines requires endogenous antigen processing. |
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| Authors: | Rood JE; Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA. ROODJ@chop.edu., Yoon SK; School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Heard MK; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Bristol Myers Squibb, Lawrenceville, NJ, USA., Carro SD; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Hedgepeth EJ; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA., O'Mara ME; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Jefferson College of Life Sciences, Thomas Jefferson University, Philadelphia, PA, USA., Hogan MJ; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA., Le N; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Drexel University College of Medicine at Tower Health, Wyomissing, PA, USA., Muramatsu H; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lam K; Genevant Sciences Corporation, Vancouver, British Columbia, Canada., Schreiner P; Genevant Sciences Corporation, Vancouver, British Columbia, Canada., Kasden C; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Stedman HH; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Langlois RA; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA., Heyes J; Genevant Sciences Corporation, Vancouver, British Columbia, Canada., Pardi N; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Eisenlohr LC; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA. eisenlc@pennmedicine.upenn.edu.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. eisenlc@pennmedicine.upenn.edu. |
| Source: | Nature communications [Nat Commun] 2026 Jan 16; Vol. 17 (1), pp. 1327. Date of Electronic Publication: 2026 Jan 16. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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