Morchella polysaccharide ameliorates myocardial infarction inflammation in mice through increasing gut microbiota-derived 12-HEPE.

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Title: Morchella polysaccharide ameliorates myocardial infarction inflammation in mice through increasing gut microbiota-derived 12-HEPE.
Authors: Su HM; Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China., Li JX; Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China., Wu JF; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China., Wu C; Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China., Sheng SH; Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China., Wang RS; Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China., Guo ZQ; Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China., Shen SC; Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China., Gao YF; Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China., Tian BD; Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China., Wang DD; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230038, China., Wu PP; School of Pharmacy, Wannan Medical College, Wuhu, 241002, China., Yin ZQ; Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China., Yang JE; Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China., Duan YJ; Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China., Ge JB; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China., Zhang S; Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230601, China. zhangshuang@hfut.edu.cn., Ma LK; Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China. lkma@ustc.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 May; Vol. 47 (5), pp. 1176-1190. Date of Electronic Publication: 2026 Jan 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
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  Data: Morchella polysaccharide ameliorates myocardial infarction inflammation in mice through increasing gut microbiota-derived 12-HEPE.
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  Data: <searchLink fieldCode="AU" term="%22Su+HM%22">Su HM</searchLink>; Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.<br /><searchLink fieldCode="AU" term="%22Li+JX%22">Li JX</searchLink>; Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.<br /><searchLink fieldCode="AU" term="%22Wu+JF%22">Wu JF</searchLink>; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.<br /><searchLink fieldCode="AU" term="%22Wu+C%22">Wu C</searchLink>; Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.<br /><searchLink fieldCode="AU" term="%22Sheng+SH%22">Sheng SH</searchLink>; Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.<br /><searchLink fieldCode="AU" term="%22Wang+RS%22">Wang RS</searchLink>; Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.<br /><searchLink fieldCode="AU" term="%22Guo+ZQ%22">Guo ZQ</searchLink>; Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.<br /><searchLink fieldCode="AU" term="%22Shen+SC%22">Shen SC</searchLink>; Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.<br /><searchLink fieldCode="AU" term="%22Gao+YF%22">Gao YF</searchLink>; Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.<br /><searchLink fieldCode="AU" term="%22Tian+BD%22">Tian BD</searchLink>; Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.<br /><searchLink fieldCode="AU" term="%22Wang+DD%22">Wang DD</searchLink>; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230038, China.<br /><searchLink fieldCode="AU" term="%22Wu+PP%22">Wu PP</searchLink>; School of Pharmacy, Wannan Medical College, Wuhu, 241002, China.<br /><searchLink fieldCode="AU" term="%22Yin+ZQ%22">Yin ZQ</searchLink>; Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.<br /><searchLink fieldCode="AU" term="%22Yang+JE%22">Yang JE</searchLink>; Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.<br /><searchLink fieldCode="AU" term="%22Duan+YJ%22">Duan YJ</searchLink>; Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.<br /><searchLink fieldCode="AU" term="%22Ge+JB%22">Ge JB</searchLink>; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230601, China. zhangshuang@hfut.edu.cn.<br /><searchLink fieldCode="AU" term="%22Ma+LK%22">Ma LK</searchLink>; Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China. lkma@ustc.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22100956087%22">Acta pharmacologica Sinica</searchLink> [Acta Pharmacol Sin] 2026 May; Vol. 47 (5), pp. 1176-1190. <i>Date of Electronic Publication: </i>2026 Jan 16.
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