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Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration and endolysosomal lipid accumulation in male PS19 mice.

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Title: Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration and endolysosomal lipid accumulation in male PS19 mice.
Authors: Tabor GT; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA; Medical Scientist Training Program, Washington University, St. Louis, MO, USA., Litvinchuk A; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA., Chen Y; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA., Allison A; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA., Sun EW; Tenvie Therapeutics, Inc., South San Francisco, CA, USA., van Lengerich B; Denali Therapeutics, Inc., South San Francisco, CA, USA., Davis SS; Denali Therapeutics, Inc., South San Francisco, CA, USA., West E; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Schlachetzki JCM; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA., Zeng C; Department of Pathology and Immunology, Washington University, St. Louis, MO, USA., Hu H; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA., Lin PB; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA., Sharma P; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA., Chen X; Laboratory of System Neuroimmunology, Institute for Immunology, IDG/McGovern Institute for Brain Research, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China., Parhizkar S; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA., Song S; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA., Bao X; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA., Senthil L; University of Chicago, Chicago, IL, USA., Iyer AK; Department of Psychiatry, Washington University, St. Louis, MO, USA., You SF; Department of Psychiatry, Washington University, St. Louis, MO, USA., Serrano JR; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA., Manis M; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA., Franke E; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA., Cashikar AG; Department of Psychiatry, Washington University, St. Louis, MO, USA., Yuede CM; Department of Psychiatry, Washington University, St. Louis, MO, USA., Suh JH; Denali Therapeutics, Inc., South San Francisco, CA, USA., Karch CM; Department of Psychiatry, Washington University, St. Louis, MO, USA., Folick A; Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Francisco, San Francisco CA, USA., Koliwad SK; Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Francisco, San Francisco CA, USA., Farese RV Jr; Cell Biology Program, Sloan Kettering Institute, New York, NY, USA., Walther T; Cell Biology Program, Sloan Kettering Institute, New York, NY, USA; Howard Hughes Medical Institute, New York, NY, USA., Huang EJ; Department of Pathology and Immunology, Washington University, St. Louis, MO, USA., Artyomov M; Department of Pathology and Immunology, Washington University, St. Louis, MO, USA., Glass CK; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Di Paolo G; Denali Therapeutics, Inc., South San Francisco, CA, USA., Ulrich JD; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA., Holtzman DM; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA. Electronic address: holtzman@wustl.edu.
Source: Cell reports [Cell Rep] 2026 Jan 27; Vol. 45 (1), pp. 116841. Date of Electronic Publication: 2026 Jan 16.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration and endolysosomal lipid accumulation in male PS19 mice.
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  Data: <searchLink fieldCode="AU" term="%22Tabor+GT%22">Tabor GT</searchLink>; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA; Medical Scientist Training Program, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Litvinchuk+A%22">Litvinchuk A</searchLink>; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Allison+A%22">Allison A</searchLink>; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Sun+EW%22">Sun EW</searchLink>; Tenvie Therapeutics, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22van+Lengerich+B%22">van Lengerich B</searchLink>; Denali Therapeutics, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Davis+SS%22">Davis SS</searchLink>; Denali Therapeutics, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22West+E%22">West E</searchLink>; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Schlachetzki+JCM%22">Schlachetzki JCM</searchLink>; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zeng+C%22">Zeng C</searchLink>; Department of Pathology and Immunology, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Hu+H%22">Hu H</searchLink>; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Lin+PB%22">Lin PB</searchLink>; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Sharma+P%22">Sharma P</searchLink>; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Laboratory of System Neuroimmunology, Institute for Immunology, IDG/McGovern Institute for Brain Research, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Parhizkar+S%22">Parhizkar S</searchLink>; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Song+S%22">Song S</searchLink>; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Bao+X%22">Bao X</searchLink>; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Senthil+L%22">Senthil L</searchLink>; University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Iyer+AK%22">Iyer AK</searchLink>; Department of Psychiatry, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22You+SF%22">You SF</searchLink>; Department of Psychiatry, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Serrano+JR%22">Serrano JR</searchLink>; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Manis+M%22">Manis M</searchLink>; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Franke+E%22">Franke E</searchLink>; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Cashikar+AG%22">Cashikar AG</searchLink>; Department of Psychiatry, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Yuede+CM%22">Yuede CM</searchLink>; Department of Psychiatry, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Suh+JH%22">Suh JH</searchLink>; Denali Therapeutics, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Karch+CM%22">Karch CM</searchLink>; Department of Psychiatry, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Folick+A%22">Folick A</searchLink>; Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Francisco, San Francisco CA, USA.<br /><searchLink fieldCode="AU" term="%22Koliwad+SK%22">Koliwad SK</searchLink>; Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Francisco, San Francisco CA, USA.<br /><searchLink fieldCode="AU" term="%22Farese+RV+Jr%22">Farese RV Jr</searchLink>; Cell Biology Program, Sloan Kettering Institute, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Walther+T%22">Walther T</searchLink>; Cell Biology Program, Sloan Kettering Institute, New York, NY, USA; Howard Hughes Medical Institute, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Huang+EJ%22">Huang EJ</searchLink>; Department of Pathology and Immunology, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Artyomov+M%22">Artyomov M</searchLink>; Department of Pathology and Immunology, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Glass+CK%22">Glass CK</searchLink>; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Di+Paolo+G%22">Di Paolo G</searchLink>; Denali Therapeutics, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ulrich+JD%22">Ulrich JD</searchLink>; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Holtzman+DM%22">Holtzman DM</searchLink>; Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA. Electronic address: holtzman@wustl.edu.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2026 Jan 27; Vol. 45 (1), pp. 116841. <i>Date of Electronic Publication: </i>2026 Jan 16.
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