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Optimizing Control Definitions in Opioid Use Disorder Genetic Research Using Electronic Health Records

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Title: Optimizing Control Definitions in Opioid Use Disorder Genetic Research Using Electronic Health Records
Transliterated Title: Optimizing Control Definitions in Opioid Use Disorder Genetic Research Using Electronic Health Records.
Authors: Niarchou M; Department of Medicine, Division of Genetic Medicine, Vanderbilt University, Nashville, Tennessee, USA., Tsai EL; Department of Medicine, Division of Genetic Medicine, Vanderbilt University, Nashville, Tennessee, USA.; Department of Genetic and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Jennings MV; Department of Psychiatry, University of California San Diego, La Jolla, California, USA., Faucon A; Department of Medicine, Division of Genetic Medicine, Vanderbilt University, Nashville, Tennessee, USA., Lee H; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Singh K; Department of Medicine, Division of Genetic Medicine, Vanderbilt University, Nashville, Tennessee, USA., Tubbs JD; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Roussos P; Department of Genetic and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Center for Precision Medicine and Translational Therapeutics, JJ Peters VA Medical Center, Bronx, New York, USA.; Mental Illness Research Education and Clinical Center, JJ Peters VA Medical Center, Bronx, New York, USA., Ge T; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Crist RC; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Mental Illness Research, Education and Clinical Center, Veterans Integrated Service Network 4, Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA., Vickers-Smith R; Department of Epidemiology and Environmental Health, University of Kentucky College of Public Health, Lexington, Kentucky, USA., Edenberg H; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, USA., Moore A; RTI International, Research Triangle Park, North Carolina, USA., Webb BT; RTI International, Research Triangle Park, North Carolina, USA.; Virginia Institute for Psychiatric and Behavior Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA., Johnson EO; RTI International, Research Triangle Park, North Carolina, USA.; Genomics and Translational Research Center, RTI International, Research Triangle Park, North Carolina, USA., Kember RL; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Mental Illness Research, Education and Clinical Center, Veterans Integrated Service Network 4, Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA., Smoller JW; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Davis LK; Department of Medicine, Division of Genetic Medicine, Vanderbilt University, Nashville, Tennessee, USA.; Department of Genetic and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Coombes BJ; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA., Voloudakis G; Department of Genetic and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Center for Precision Medicine and Translational Therapeutics, JJ Peters VA Medical Center, Bronx, New York, USA.; Mental Illness Research Education and Clinical Center, JJ Peters VA Medical Center, Bronx, New York, USA.; Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Burstein D; Department of Genetic and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Center for Precision Medicine and Translational Therapeutics, JJ Peters VA Medical Center, Bronx, New York, USA.; Mental Illness Research Education and Clinical Center, JJ Peters VA Medical Center, Bronx, New York, USA., Mallard TT; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Troiani V; Geisinger College of Health Sciences, Scranton, Pennsylvania, USA., Sanchez-Roige S; Department of Medicine, Division of Genetic Medicine, Vanderbilt University, Nashville, Tennessee, USA.; Department of Psychiatry, University of California San Diego, La Jolla, California, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, California, USA.
Corporate Authors: PsycheMERGE Substance Use Disorder Workgroup
Source: Addiction biology [Addict Biol] 2026 Jan; Vol. 31 (1), pp. e70094.
Publication Type: English Abstract; Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 9604935 Publication Model: Print Cited Medium: Internet ISSN: 1369-1600 (Electronic) Linking ISSN: 13556215 NLM ISO Abbreviation: Addict Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Optimizing Control Definitions in Opioid Use Disorder Genetic Research Using Electronic Health Records
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  Data: Optimizing Control Definitions in Opioid Use Disorder Genetic Research Using Electronic Health Records.
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  Data: <searchLink fieldCode="AU" term="%22Niarchou+M%22">Niarchou M</searchLink>; Department of Medicine, Division of Genetic Medicine, Vanderbilt University, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Tsai+EL%22">Tsai EL</searchLink>; Department of Medicine, Division of Genetic Medicine, Vanderbilt University, Nashville, Tennessee, USA.; Department of Genetic and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Jennings+MV%22">Jennings MV</searchLink>; Department of Psychiatry, University of California San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Faucon+A%22">Faucon A</searchLink>; Department of Medicine, Division of Genetic Medicine, Vanderbilt University, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Lee+H%22">Lee H</searchLink>; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Singh+K%22">Singh K</searchLink>; Department of Medicine, Division of Genetic Medicine, Vanderbilt University, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Tubbs+JD%22">Tubbs JD</searchLink>; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Roussos+P%22">Roussos P</searchLink>; Department of Genetic and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Center for Precision Medicine and Translational Therapeutics, JJ Peters VA Medical Center, Bronx, New York, USA.; Mental Illness Research Education and Clinical Center, JJ Peters VA Medical Center, Bronx, New York, USA.<br /><searchLink fieldCode="AU" term="%22Ge+T%22">Ge T</searchLink>; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Crist+RC%22">Crist RC</searchLink>; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Mental Illness Research, Education and Clinical Center, Veterans Integrated Service Network 4, Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Vickers-Smith+R%22">Vickers-Smith R</searchLink>; Department of Epidemiology and Environmental Health, University of Kentucky College of Public Health, Lexington, Kentucky, USA.<br /><searchLink fieldCode="AU" term="%22Edenberg+H%22">Edenberg H</searchLink>; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, USA.<br /><searchLink fieldCode="AU" term="%22Moore+A%22">Moore A</searchLink>; RTI International, Research Triangle Park, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Webb+BT%22">Webb BT</searchLink>; RTI International, Research Triangle Park, North Carolina, USA.; Virginia Institute for Psychiatric and Behavior Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+EO%22">Johnson EO</searchLink>; RTI International, Research Triangle Park, North Carolina, USA.; Genomics and Translational Research Center, RTI International, Research Triangle Park, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Kember+RL%22">Kember RL</searchLink>; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Mental Illness Research, Education and Clinical Center, Veterans Integrated Service Network 4, Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Smoller+JW%22">Smoller JW</searchLink>; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Davis+LK%22">Davis LK</searchLink>; Department of Medicine, Division of Genetic Medicine, Vanderbilt University, Nashville, Tennessee, USA.; Department of Genetic and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Coombes+BJ%22">Coombes BJ</searchLink>; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Voloudakis+G%22">Voloudakis G</searchLink>; Department of Genetic and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Center for Precision Medicine and Translational Therapeutics, JJ Peters VA Medical Center, Bronx, New York, USA.; Mental Illness Research Education and Clinical Center, JJ Peters VA Medical Center, Bronx, New York, USA.; Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Burstein+D%22">Burstein D</searchLink>; Department of Genetic and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Center for Precision Medicine and Translational Therapeutics, JJ Peters VA Medical Center, Bronx, New York, USA.; Mental Illness Research Education and Clinical Center, JJ Peters VA Medical Center, Bronx, New York, USA.<br /><searchLink fieldCode="AU" term="%22Mallard+TT%22">Mallard TT</searchLink>; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Troiani+V%22">Troiani V</searchLink>; Geisinger College of Health Sciences, Scranton, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Sanchez-Roige+S%22">Sanchez-Roige S</searchLink>; Department of Medicine, Division of Genetic Medicine, Vanderbilt University, Nashville, Tennessee, USA.; Department of Psychiatry, University of California San Diego, La Jolla, California, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, California, USA.
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