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Targeting metabolic vulnerabilities: REV-ERB agonist SR9009 potentiates sorafenib efficacy in liver cancer.

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Title: Targeting metabolic vulnerabilities: REV-ERB agonist SR9009 potentiates sorafenib efficacy in liver cancer.
Authors: Sabbioni S; Department of Life Sciences and Biotechnology, University of Ferrara, 44121, Ferrara, Italy. silvia.sabbioni@unife.it.; Laboratorio Per Le Tecnologie Delle Terapie Avanzate (LTTA), University of Ferrara, 44121, Ferrara, Italy. silvia.sabbioni@unife.it., Guerriero P; Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy., Shankaraiah RC; Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy.; Glaxo Smith Kline - Wavre Belgium Av. Fleming 20, 1300, Wavre, Belgium., Masatti L; Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy.; Department of Biology, University of Padova, 35100, Padova, Italy., Michilli A; Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy., Bassi C; Laboratorio Per Le Tecnologie Delle Terapie Avanzate (LTTA), University of Ferrara, 44121, Ferrara, Italy.; Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy., D'Abundo L; Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy., Moshiri F; Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy., De Siena B; Department of Life Sciences and Biotechnology, University of Ferrara, 44121, Ferrara, Italy., Simoni E; Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy.; Bioacoustics Research Laboratory, Department of Neurosciences, University of Padova, 35129, Padova, Italy., Astolfi L; Bioacoustics Research Laboratory, Department of Neurosciences, University of Padova, 35129, Padova, Italy., Gramantieri L; Division of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138, Bologna, Italy., Roncarati R; Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy.; CNR Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', Unit of Bologna, Bologna, Italy., Elamin BK; Department of Microbiology and Clinical Parasitology, College of Medicine, University of Bisha, Bisha, 61922, Saudi Arabia.; Department of Medical Microbiology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan., Bonora M; Department of Medical Sciences, Section of Experimental Medicine, University of Ferrara, 44121, Ferrara, Italy., Pinton P; Department of Medical Sciences, Section of Experimental Medicine, University of Ferrara, 44121, Ferrara, Italy., Croce CM; Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA., Negrini M; Laboratorio Per Le Tecnologie Delle Terapie Avanzate (LTTA), University of Ferrara, 44121, Ferrara, Italy. massimo.negrini@unife.it.; Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy. massimo.negrini@unife.it., Callegari E; Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy. elisa.callegari@unife.it.
Source: Cell death discovery [Cell Death Discov] 2026 Jan 19; Vol. 12 (1), pp. 86. Date of Electronic Publication: 2026 Jan 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting metabolic vulnerabilities: REV-ERB agonist SR9009 potentiates sorafenib efficacy in liver cancer.
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  Data: <searchLink fieldCode="AU" term="%22Sabbioni+S%22">Sabbioni S</searchLink>; Department of Life Sciences and Biotechnology, University of Ferrara, 44121, Ferrara, Italy. silvia.sabbioni@unife.it.; Laboratorio Per Le Tecnologie Delle Terapie Avanzate (LTTA), University of Ferrara, 44121, Ferrara, Italy. silvia.sabbioni@unife.it.<br /><searchLink fieldCode="AU" term="%22Guerriero+P%22">Guerriero P</searchLink>; Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Shankaraiah+RC%22">Shankaraiah RC</searchLink>; Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy.; Glaxo Smith Kline - Wavre Belgium Av. Fleming 20, 1300, Wavre, Belgium.<br /><searchLink fieldCode="AU" term="%22Masatti+L%22">Masatti L</searchLink>; Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy.; Department of Biology, University of Padova, 35100, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Michilli+A%22">Michilli A</searchLink>; Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Bassi+C%22">Bassi C</searchLink>; Laboratorio Per Le Tecnologie Delle Terapie Avanzate (LTTA), University of Ferrara, 44121, Ferrara, Italy.; Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22D'Abundo+L%22">D'Abundo L</searchLink>; Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Moshiri+F%22">Moshiri F</searchLink>; Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22De+Siena+B%22">De Siena B</searchLink>; Department of Life Sciences and Biotechnology, University of Ferrara, 44121, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Simoni+E%22">Simoni E</searchLink>; Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy.; Bioacoustics Research Laboratory, Department of Neurosciences, University of Padova, 35129, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Astolfi+L%22">Astolfi L</searchLink>; Bioacoustics Research Laboratory, Department of Neurosciences, University of Padova, 35129, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Gramantieri+L%22">Gramantieri L</searchLink>; Division of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Roncarati+R%22">Roncarati R</searchLink>; Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy.; CNR Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', Unit of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Elamin+BK%22">Elamin BK</searchLink>; Department of Microbiology and Clinical Parasitology, College of Medicine, University of Bisha, Bisha, 61922, Saudi Arabia.; Department of Medical Microbiology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.<br /><searchLink fieldCode="AU" term="%22Bonora+M%22">Bonora M</searchLink>; Department of Medical Sciences, Section of Experimental Medicine, University of Ferrara, 44121, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Pinton+P%22">Pinton P</searchLink>; Department of Medical Sciences, Section of Experimental Medicine, University of Ferrara, 44121, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Croce+CM%22">Croce CM</searchLink>; Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Negrini+M%22">Negrini M</searchLink>; Laboratorio Per Le Tecnologie Delle Terapie Avanzate (LTTA), University of Ferrara, 44121, Ferrara, Italy. massimo.negrini@unife.it.; Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy. massimo.negrini@unife.it.<br /><searchLink fieldCode="AU" term="%22Callegari+E%22">Callegari E</searchLink>; Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy. elisa.callegari@unife.it.
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  Data: <searchLink fieldCode="JN" term="%22101665035%22">Cell death discovery</searchLink> [Cell Death Discov] 2026 Jan 19; Vol. 12 (1), pp. 86. <i>Date of Electronic Publication: </i>2026 Jan 19.
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              Text: 2026 Jan 19
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