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Higher stability of novel live-attenuated oral poliovirus type 2 (nOPV2) despite the emergence of a neurovirulent double recombinant strain in Uganda.

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Title: Higher stability of novel live-attenuated oral poliovirus type 2 (nOPV2) despite the emergence of a neurovirulent double recombinant strain in Uganda.
Authors: Tushabe P; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Majumdar M; Medicines and Healthcare products Regulatory Agency (MHRA), Hertfordshire, UK., Carlyle S; Medicines and Healthcare products Regulatory Agency (MHRA), Hertfordshire, UK., Shulman L; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Ssekagiri A; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Joffret ML; Institut Pasteur, Paris, France., Klapsa D; Medicines and Healthcare products Regulatory Agency (MHRA), Hertfordshire, UK., Cremer J; National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands., Arowolo KO; Medicines and Healthcare products Regulatory Agency (MHRA), Hertfordshire, UK., Bujaki E; Medicines and Healthcare products Regulatory Agency (MHRA), Hertfordshire, UK., Bukenya H; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Nanteza MB; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Turyahabwe I; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Namuwulya P; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Birungi M; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Eliku JP; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Aine F; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Tibanagwa M; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Nakabazzi L; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Gaizi J; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Ssebuuma AM; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Dhatemwa R; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Okia C; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Nyachwo M; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Nanteza MB; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Turyahabwe I; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Namuwulya P; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Birungi M; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Eliku JP; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Aine F; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Tibanagwa M; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Nakabazzi L; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Gaizi J; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Ssebuuma AM; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Dhatemwa R; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Okia C; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Nyachwo M; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Hawes KM; Bill and Melinda Gates Foundation, Seattle, WA, USA., Bakamutumaho B; Uganda Virus Research Institute (UVRI), Entebbe, Uganda., Duizer E; National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands., Bessaud M; Institut Pasteur, Paris, France., Bandyopadhyay AS; Bill and Melinda Gates Foundation, Seattle, WA, USA., Macadam A; Medicines and Healthcare products Regulatory Agency (MHRA), Hertfordshire, UK., Byabamazima CR; World Health Organization Regional Office for Africa (AFRO), Harare, Zimbabwe., Martin J; Medicines and Healthcare products Regulatory Agency (MHRA), Hertfordshire, UK. Javier.Martin@mhra.gov.uk., Bwogi J; Uganda Virus Research Institute (UVRI), Entebbe, Uganda.
Corporate Authors: EPI Laboratory team
Source: Nature microbiology [Nat Microbiol] 2026 Feb; Vol. 11 (2), pp. 406-414. Date of Electronic Publication: 2026 Jan 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE
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