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Virus-Specific T Cells and Response to Checkpoint Inhibitors in Progressive Multifocal Leukoencephalopathy.

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Title: Virus-Specific T Cells and Response to Checkpoint Inhibitors in Progressive Multifocal Leukoencephalopathy.
Authors: Möhn N; Department of Neurology, Hannover Medical School, Hannover, Germany.; Center of Neurology, Department of Neuroimmunology, University Hospital and University Bonn, Germany., Grote-Levi L; Department of Neurology, Hannover Medical School, Hannover, Germany., Bonifacius A; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany., Tischer-Zimmermann S; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany., Nay S; Department of Neurology, Hannover Medical School, Hannover, Germany., Jendretzky KF; Department of Neurology, Hannover Medical School, Hannover, Germany., Sassmann ML; Department of Neurology, Hannover Medical School, Hannover, Germany., Karacondi K; Department of Neurology, Hannover Medical School, Hannover, Germany., Zent M; Department of Neurology, Hannover Medical School, Hannover, Germany., Konen FF; Department of Neurology, Hannover Medical School, Hannover, Germany., Sühs KW; Department of Neurology, Hannover Medical School, Hannover, Germany., Meuth SG; Department of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Pawlitzki M; Department of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Warnke C; Department of Neurology, Philipps University Marburg, Marburg, Germany.; Department of Neurology, University Hospital Gießen and Marburg, Baldingerstraße, Marburg, Germany., Ayzenberg I; Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany., Schneider R; Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany., Helmchen C; Department of Neurology, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Brüggemann N; Department of Neurology, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Klebe S; Department of Neurology, Essen University Hospital, Essen, Germany., Hildner M; Department of Neurology, Goethe University Frankfurt and University Hospital Frankfurt, Frankfurt, Germany., Grefkes C; Department of Neurology, Goethe University Frankfurt and University Hospital Frankfurt, Frankfurt, Germany., Nitsch L; Center of Neurology, Department of Neuroimmunology, University Hospital Bonn, Germany., Hühnchen P; Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Böltz S; Medizinische Klinik 3 - Rheumatologie and Immunologie, Friedrich-Alexander-Universität Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany.; Deutsches Zentrum für Immuntherapie (DZI), Friedrich-Alexander-Universität Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany., Alt L; Department of Neurology, University Hospital Ulm, Ulm, Germany., Tumani H; Department of Neurology, University Hospital Ulm, Ulm, Germany., Kleinschnitz C; Department of Neurology, University Medicine Essen, Essen, Germany., Pul R; Department of Neurology, University Medicine Essen, Essen, Germany., Grauer O; Department of Neurology, University Hospital Münster, Münster, Germany., Clifford D; Department of Neurology, Washington University in St Louis, St Louis, Missouri., Gnanapavan S; Department of Neurology, Barts Health NHS Trust and Queen Mary University of London, London, United Kingdom., Wicklein R; Department of Neurology, Technical University of Munich, Munich, Germany., Perpoint T; Department of Infectious and Tropical Diseases, Lyon University Hospital, Lyon, France., Beudel M; Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands., Del Bello A; Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France., Rauer S; Department of Neurology, Medical Center, University of Freiburg, Freiburg, Germany., Wiendl H; Department of Neurology, University Hospital Münster, Münster, Germany.; Department of Neurology, Medical Center, University of Freiburg, Freiburg, Germany., Jelcic I; Neuroimmunology and Multiple Sclerosis Research Section, Department of Neurology, University Hospital Zurich and University of Zurich, Zurich, Switzerland., Gasnault J; Unit of Rehabilitation of Neuroviral Diseases, Bicêtre Hospital, APHP, Le Kremlin-Bicêtre, France., Cimini E; Cellular Immunology and Pharmacology Laboratory, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy., Antinori A; Clinical and Research Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy., Pinnetti C; Clinical and Research Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy., Pourcher V; Department of Infectious Diseases, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France., Weiss N; Department of Intensive Care Unit, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France., Lambert N; Department of Neurology, CHU de Liège/Hôpital de la Citadelle, Liège, Belgium., Maecker-Kolhoff B; Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany., Höglinger GU; Department of Neurology, LMU University Hospital, Ludwig-Maximilians-Universität (LMU) München, Munich, Germany.; German Center for Neurodegenerative Diseases, Munich, Germany.; Munich Cluster for Systems Neurology, Munich, Germany., Zahraeifard S; Experimental Immunotherapeutics Unit, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland., Cortese I; Experimental Immunotherapeutics Unit, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland., Eiz-Vesper B; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany., Martin-Blondel G; Infectious Diseases Department, University Hospital Center of Toulouse, Toulouse, France.; Toulouse Institute for Infectious and Inflammatory Diseases, INSERM UMR1291, CNRS UMR5051, University of Toulouse, Toulouse, France.; NEO-I3D Research Group, Toulouse University Hospital, Toulouse, France., Skripuletz T; Department of Neurology, Hannover Medical School, Hannover, Germany.
Corporate Authors: Immunotherapy for PML Study Group
Source: JAMA neurology [JAMA Neurol] 2026 Mar 01; Vol. 83 (3), pp. 280-289.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589536 Publication Model: Print Cited Medium: Internet ISSN: 2168-6157 (Electronic) Linking ISSN: 21686149 NLM ISO Abbreviation: JAMA Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:2168-6157
DOI:10.1001/jamaneurol.2025.5318