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Pyruvate kinase deficiency modifies sickle hemoglobin carrier and sickle cell disease phenotypes in mice.

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Title: Pyruvate kinase deficiency modifies sickle hemoglobin carrier and sickle cell disease phenotypes in mice.
Authors: Wang X; Sickle Cell Branch, National Heart Lung and Blood Institute., Smith M; Department of Perioperative Medicine, National Institutes of Health Clinical Center., Kamimura S; Department of Perioperative Medicine, National Institutes of Health Clinical Center., Li Q; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases., Shah N; Laboratory of Pathology, National Cancer Institute., Quezado M; Laboratory of Pathology, National Cancer Institute., Almeida LE; Department of Perioperative Medicine, National Institutes of Health Clinical Center., Vogel S; Department of Perioperative Medicine, National Institutes of Health Clinical Center., Tegegn MB; Sickle Cell Branch, National Heart Lung and Blood Institute., Sun KY; Sickle Cell Branch, National Heart Lung and Blood Institute., Villasmil R; Flow Cytometry Core Facility, National Eye Institute, and., Liu C; National Heart Lung and Blood Institute, NIH, Bethesda, Maryland, USA., Eaton WA; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases., Thein SL; Sickle Cell Branch, National Heart Lung and Blood Institute., Quezado ZM; Sickle Cell Branch, National Heart Lung and Blood Institute.; Department of Perioperative Medicine, National Institutes of Health Clinical Center.
Source: JCI insight [JCI Insight] 2026 Jan 08; Vol. 11 (4). Date of Electronic Publication: 2026 Jan 08 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: eCollection Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Pyruvate kinase deficiency modifies sickle hemoglobin carrier and sickle cell disease phenotypes in mice.
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  Data: <searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Sickle Cell Branch, National Heart Lung and Blood Institute.<br /><searchLink fieldCode="AU" term="%22Smith+M%22">Smith M</searchLink>; Department of Perioperative Medicine, National Institutes of Health Clinical Center.<br /><searchLink fieldCode="AU" term="%22Kamimura+S%22">Kamimura S</searchLink>; Department of Perioperative Medicine, National Institutes of Health Clinical Center.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases.<br /><searchLink fieldCode="AU" term="%22Shah+N%22">Shah N</searchLink>; Laboratory of Pathology, National Cancer Institute.<br /><searchLink fieldCode="AU" term="%22Quezado+M%22">Quezado M</searchLink>; Laboratory of Pathology, National Cancer Institute.<br /><searchLink fieldCode="AU" term="%22Almeida+LE%22">Almeida LE</searchLink>; Department of Perioperative Medicine, National Institutes of Health Clinical Center.<br /><searchLink fieldCode="AU" term="%22Vogel+S%22">Vogel S</searchLink>; Department of Perioperative Medicine, National Institutes of Health Clinical Center.<br /><searchLink fieldCode="AU" term="%22Tegegn+MB%22">Tegegn MB</searchLink>; Sickle Cell Branch, National Heart Lung and Blood Institute.<br /><searchLink fieldCode="AU" term="%22Sun+KY%22">Sun KY</searchLink>; Sickle Cell Branch, National Heart Lung and Blood Institute.<br /><searchLink fieldCode="AU" term="%22Villasmil+R%22">Villasmil R</searchLink>; Flow Cytometry Core Facility, National Eye Institute, and.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; National Heart Lung and Blood Institute, NIH, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Eaton+WA%22">Eaton WA</searchLink>; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases.<br /><searchLink fieldCode="AU" term="%22Thein+SL%22">Thein SL</searchLink>; Sickle Cell Branch, National Heart Lung and Blood Institute.<br /><searchLink fieldCode="AU" term="%22Quezado+ZM%22">Quezado ZM</searchLink>; Sickle Cell Branch, National Heart Lung and Blood Institute.; Department of Perioperative Medicine, National Institutes of Health Clinical Center.
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  Data: <searchLink fieldCode="JN" term="%22101676073%22">JCI insight</searchLink> [JCI Insight] 2026 Jan 08; Vol. 11 (4). <i>Date of Electronic Publication: </i>2026 Jan 08 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Clinical+Investigation%22">American Society for Clinical Investigation </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101676073 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2379-3708 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223793708%22">23793708 </searchLink><i>NLM ISO Abbreviation: </i>JCI Insight <i>Subsets: </i>MEDLINE
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        Value: 10.1172/jci.insight.195682
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              Text: 2026 Jan 08
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