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A novel photosensitizer berberine derivative B12 induces apoptosis and suppresses HIF-1α expression in colorectal cancer cells via mitochondria-to-nucleus sequential-targeting.

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Title: A novel photosensitizer berberine derivative B12 induces apoptosis and suppresses HIF-1α expression in colorectal cancer cells via mitochondria-to-nucleus sequential-targeting.
Authors: Pei WB; Xiamen Key Laboratory for Tumor Metastasis, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361102, China., Lei ZY; Xiamen Key Laboratory for Tumor Metastasis, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361102, China.; Cancer Hospital, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361003, China.; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases (Ministry of Education), Gannan Medical University, Ganzhou, 341000, China., Xie FQ; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, 400037, China.; Chongqing Key Laboratory of Precision Medicine and Prevention of Major Respiratory Diseases, Chongqing, 400037, China., Chen P; Department of Chemistry and Key Laboratory of Chemical Biology of Fujian Province, iChEM, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China., Su YC; Xiamen Key Laboratory for Tumor Metastasis, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361102, China.; Cancer Hospital, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361003, China., Qin YS; Department of Chemistry and Key Laboratory of Chemical Biology of Fujian Province, iChEM, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China., Li JQ; Xiamen Key Laboratory for Tumor Metastasis, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361102, China., Shen QW; Xiamen Key Laboratory for Tumor Metastasis, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361102, China., Ma MM; Xiamen Key Laboratory for Tumor Metastasis, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361102, China., Gao CY; Xiamen Key Laboratory for Tumor Metastasis, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361102, China., Zhu JC; Xiamen Key Laboratory for Tumor Metastasis, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361102, China., Xu YJ; Xiamen Key Laboratory for Tumor Metastasis, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361102, China., Zhang KY; Xiamen Key Laboratory for Tumor Metastasis, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361102, China., Zhang WQ; Xiamen Key Laboratory for Tumor Metastasis, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361102, China., Zhang YD; Department of Chemistry and Key Laboratory of Chemical Biology of Fujian Province, iChEM, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China. ydzhang@xmu.edu.cn., Hu TH; Xiamen Key Laboratory for Tumor Metastasis, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361102, China. thu@xmu.edu.cn.; Cancer Hospital, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361003, China. thu@xmu.edu.cn.; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases (Ministry of Education), Gannan Medical University, Ganzhou, 341000, China. thu@xmu.edu.cn.; Shenzhen Research Institute of Xiamen University, Shenzhen, 518057, China. thu@xmu.edu.cn., Xu BB; Department of Stem Cell and Regenerative Medicine, International Joint Research Center for Precision Biotherapy, Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China. xubeibei@tmmu.edu.cn.; Jin-feng Laboratory, Chongqing, 401329, China. xubeibei@tmmu.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 May; Vol. 47 (5), pp. 1249-1269. Date of Electronic Publication: 2026 Jan 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A novel photosensitizer berberine derivative B12 induces apoptosis and suppresses HIF-1α expression in colorectal cancer cells via mitochondria-to-nucleus sequential-targeting.
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  Data: <searchLink fieldCode="AU" term="%22Pei+WB%22">Pei WB</searchLink>; Xiamen Key Laboratory for Tumor Metastasis, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361102, China.<br /><searchLink fieldCode="AU" term="%22Lei+ZY%22">Lei ZY</searchLink>; Xiamen Key Laboratory for Tumor Metastasis, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361102, China.; Cancer Hospital, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361003, China.; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases (Ministry of Education), Gannan Medical University, Ganzhou, 341000, China.<br /><searchLink fieldCode="AU" term="%22Xie+FQ%22">Xie FQ</searchLink>; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, 400037, China.; Chongqing Key Laboratory of Precision Medicine and Prevention of Major Respiratory Diseases, Chongqing, 400037, China.<br /><searchLink fieldCode="AU" term="%22Chen+P%22">Chen P</searchLink>; Department of Chemistry and Key Laboratory of Chemical Biology of Fujian Province, iChEM, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China.<br /><searchLink fieldCode="AU" term="%22Su+YC%22">Su YC</searchLink>; Xiamen Key Laboratory for Tumor Metastasis, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361102, China.; Cancer Hospital, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361003, China.<br /><searchLink fieldCode="AU" term="%22Qin+YS%22">Qin YS</searchLink>; Department of Chemistry and Key Laboratory of Chemical Biology of Fujian Province, iChEM, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China.<br /><searchLink fieldCode="AU" term="%22Li+JQ%22">Li JQ</searchLink>; Xiamen Key Laboratory for Tumor Metastasis, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361102, China.<br /><searchLink fieldCode="AU" term="%22Shen+QW%22">Shen QW</searchLink>; Xiamen Key Laboratory for Tumor Metastasis, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361102, China.<br /><searchLink fieldCode="AU" term="%22Ma+MM%22">Ma MM</searchLink>; Xiamen Key Laboratory for Tumor Metastasis, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361102, China.<br /><searchLink fieldCode="AU" term="%22Gao+CY%22">Gao CY</searchLink>; Xiamen Key Laboratory for Tumor Metastasis, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361102, China.<br /><searchLink fieldCode="AU" term="%22Zhu+JC%22">Zhu JC</searchLink>; Xiamen Key Laboratory for Tumor Metastasis, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361102, China.<br /><searchLink fieldCode="AU" term="%22Xu+YJ%22">Xu YJ</searchLink>; Xiamen Key Laboratory for Tumor Metastasis, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361102, China.<br /><searchLink fieldCode="AU" term="%22Zhang+KY%22">Zhang KY</searchLink>; Xiamen Key Laboratory for Tumor Metastasis, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361102, China.<br /><searchLink fieldCode="AU" term="%22Zhang+WQ%22">Zhang WQ</searchLink>; Xiamen Key Laboratory for Tumor Metastasis, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361102, China.<br /><searchLink fieldCode="AU" term="%22Zhang+YD%22">Zhang YD</searchLink>; Department of Chemistry and Key Laboratory of Chemical Biology of Fujian Province, iChEM, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China. ydzhang@xmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Hu+TH%22">Hu TH</searchLink>; Xiamen Key Laboratory for Tumor Metastasis, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361102, China. thu@xmu.edu.cn.; Cancer Hospital, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361003, China. thu@xmu.edu.cn.; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases (Ministry of Education), Gannan Medical University, Ganzhou, 341000, China. thu@xmu.edu.cn.; Shenzhen Research Institute of Xiamen University, Shenzhen, 518057, China. thu@xmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Xu+BB%22">Xu BB</searchLink>; Department of Stem Cell and Regenerative Medicine, International Joint Research Center for Precision Biotherapy, Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China. xubeibei@tmmu.edu.cn.; Jin-feng Laboratory, Chongqing, 401329, China. xubeibei@tmmu.edu.cn.
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