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Selective targeting of NRF2-high pancreatic ductal adenocarcinoma with an NQO1-activatable prodrug.

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Title: Selective targeting of NRF2-high pancreatic ductal adenocarcinoma with an NQO1-activatable prodrug.
Authors: Antonucci L; Department of Pharmacology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093.; Department of Pathology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093., Watari K; Department of Pharmacology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093.; Department of Pathology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093., Feng Y; Department of Pharmacology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093.; Department of Pathology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093., Qi J; Department of Pharmacology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093.; Department of Pathology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093., Zhu M; Department of Pharmacology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093.; Department of Pathology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093., Wang T; Department of Oncology, Zhongda Hospital, Southeast University, Nanjing 210009, China., Ng I; Moores Cancer Center, University of California San Diego, La Jolla, CA 92037., Vucic EA; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016., Riahi I; Department of Pathology, Jonsson Cancer Center, University of California Los Angeles David Geffen School of Medicine Los Angeles, CA 90095.; Department of Laboratory Medicine, Jonsson Cancer Center, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA 90095., Huang L; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China., Hosseini M; Department of Pathology, University of California San Diego School of Medicine, La Jolla, CA 92093., Mose E; Department of Surgery, University of California San Diego School of Medicine, La Jolla, CA 92093., French R; Department of Surgery, University of California San Diego School of Medicine, La Jolla, CA 92093., Weitz J; Department of Surgery, University of California San Diego School of Medicine, La Jolla, CA 92093., Bar-Sagi D; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016., Dawson DW; Department of Pathology, Jonsson Cancer Center, University of California Los Angeles David Geffen School of Medicine Los Angeles, CA 90095.; Department of Laboratory Medicine, Jonsson Cancer Center, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA 90095., Sun B; Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China., Tiriac H; Moores Cancer Center, University of California San Diego, La Jolla, CA 92037.; Department of Surgery, University of California San Diego School of Medicine, La Jolla, CA 92093., Xu J; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China., Xu S; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China., Lowy AM; Department of Surgery, University of California San Diego School of Medicine, La Jolla, CA 92093., Karin M; Department of Pharmacology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093.; Department of Pathology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jan 27; Vol. 123 (4), pp. e2511733123. Date of Electronic Publication: 2026 Jan 21.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Selective targeting of NRF2-high pancreatic ductal adenocarcinoma with an NQO1-activatable prodrug.
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  Data: <searchLink fieldCode="AU" term="%22Antonucci+L%22">Antonucci L</searchLink>; Department of Pharmacology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093.; Department of Pathology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093.<br /><searchLink fieldCode="AU" term="%22Watari+K%22">Watari K</searchLink>; Department of Pharmacology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093.; Department of Pathology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093.<br /><searchLink fieldCode="AU" term="%22Feng+Y%22">Feng Y</searchLink>; Department of Pharmacology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093.; Department of Pathology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093.<br /><searchLink fieldCode="AU" term="%22Qi+J%22">Qi J</searchLink>; Department of Pharmacology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093.; Department of Pathology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093.<br /><searchLink fieldCode="AU" term="%22Zhu+M%22">Zhu M</searchLink>; Department of Pharmacology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093.; Department of Pathology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093.<br /><searchLink fieldCode="AU" term="%22Wang+T%22">Wang T</searchLink>; Department of Oncology, Zhongda Hospital, Southeast University, Nanjing 210009, China.<br /><searchLink fieldCode="AU" term="%22Ng+I%22">Ng I</searchLink>; Moores Cancer Center, University of California San Diego, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Vucic+EA%22">Vucic EA</searchLink>; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016.<br /><searchLink fieldCode="AU" term="%22Riahi+I%22">Riahi I</searchLink>; Department of Pathology, Jonsson Cancer Center, University of California Los Angeles David Geffen School of Medicine Los Angeles, CA 90095.; Department of Laboratory Medicine, Jonsson Cancer Center, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA 90095.<br /><searchLink fieldCode="AU" term="%22Huang+L%22">Huang L</searchLink>; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China.<br /><searchLink fieldCode="AU" term="%22Hosseini+M%22">Hosseini M</searchLink>; Department of Pathology, University of California San Diego School of Medicine, La Jolla, CA 92093.<br /><searchLink fieldCode="AU" term="%22Mose+E%22">Mose E</searchLink>; Department of Surgery, University of California San Diego School of Medicine, La Jolla, CA 92093.<br /><searchLink fieldCode="AU" term="%22French+R%22">French R</searchLink>; Department of Surgery, University of California San Diego School of Medicine, La Jolla, CA 92093.<br /><searchLink fieldCode="AU" term="%22Weitz+J%22">Weitz J</searchLink>; Department of Surgery, University of California San Diego School of Medicine, La Jolla, CA 92093.<br /><searchLink fieldCode="AU" term="%22Bar-Sagi+D%22">Bar-Sagi D</searchLink>; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016.<br /><searchLink fieldCode="AU" term="%22Dawson+DW%22">Dawson DW</searchLink>; Department of Pathology, Jonsson Cancer Center, University of California Los Angeles David Geffen School of Medicine Los Angeles, CA 90095.; Department of Laboratory Medicine, Jonsson Cancer Center, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA 90095.<br /><searchLink fieldCode="AU" term="%22Sun+B%22">Sun B</searchLink>; Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.<br /><searchLink fieldCode="AU" term="%22Tiriac+H%22">Tiriac H</searchLink>; Moores Cancer Center, University of California San Diego, La Jolla, CA 92037.; Department of Surgery, University of California San Diego School of Medicine, La Jolla, CA 92093.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.<br /><searchLink fieldCode="AU" term="%22Xu+S%22">Xu S</searchLink>; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.<br /><searchLink fieldCode="AU" term="%22Lowy+AM%22">Lowy AM</searchLink>; Department of Surgery, University of California San Diego School of Medicine, La Jolla, CA 92093.<br /><searchLink fieldCode="AU" term="%22Karin+M%22">Karin M</searchLink>; Department of Pharmacology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093.; Department of Pathology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2026 Jan 27; Vol. 123 (4), pp. e2511733123. <i>Date of Electronic Publication: </i>2026 Jan 21.
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