Selective targeting of NRF2-high pancreatic ductal adenocarcinoma with an NQO1-activatable prodrug.
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| Title: | Selective targeting of NRF2-high pancreatic ductal adenocarcinoma with an NQO1-activatable prodrug. |
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| Authors: | Antonucci L; Department of Pharmacology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093.; Department of Pathology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093., Watari K; Department of Pharmacology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093.; Department of Pathology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093., Feng Y; Department of Pharmacology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093.; Department of Pathology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093., Qi J; Department of Pharmacology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093.; Department of Pathology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093., Zhu M; Department of Pharmacology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093.; Department of Pathology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093., Wang T; Department of Oncology, Zhongda Hospital, Southeast University, Nanjing 210009, China., Ng I; Moores Cancer Center, University of California San Diego, La Jolla, CA 92037., Vucic EA; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016., Riahi I; Department of Pathology, Jonsson Cancer Center, University of California Los Angeles David Geffen School of Medicine Los Angeles, CA 90095.; Department of Laboratory Medicine, Jonsson Cancer Center, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA 90095., Huang L; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China., Hosseini M; Department of Pathology, University of California San Diego School of Medicine, La Jolla, CA 92093., Mose E; Department of Surgery, University of California San Diego School of Medicine, La Jolla, CA 92093., French R; Department of Surgery, University of California San Diego School of Medicine, La Jolla, CA 92093., Weitz J; Department of Surgery, University of California San Diego School of Medicine, La Jolla, CA 92093., Bar-Sagi D; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016., Dawson DW; Department of Pathology, Jonsson Cancer Center, University of California Los Angeles David Geffen School of Medicine Los Angeles, CA 90095.; Department of Laboratory Medicine, Jonsson Cancer Center, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA 90095., Sun B; Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China., Tiriac H; Moores Cancer Center, University of California San Diego, La Jolla, CA 92037.; Department of Surgery, University of California San Diego School of Medicine, La Jolla, CA 92093., Xu J; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China., Xu S; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China., Lowy AM; Department of Surgery, University of California San Diego School of Medicine, La Jolla, CA 92093., Karin M; Department of Pharmacology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093.; Department of Pathology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, La Jolla, CA 92093. |
| Source: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jan 27; Vol. 123 (4), pp. e2511733123. Date of Electronic Publication: 2026 Jan 21. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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