Osimertinib inhibits the MYLK4-mediated phosphorylation of CDKAL1 to suppress stemness and chemoresistance in rhabdomyosarcoma.
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| Title: | Osimertinib inhibits the MYLK4-mediated phosphorylation of CDKAL1 to suppress stemness and chemoresistance in rhabdomyosarcoma. |
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| Authors: | Itano T; Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.; Department of Musculoskeletal Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan., Huang R; Department of Cellular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.; Department of Trauma Orthopedics, The Second Hospital of Dalian Medical University, Dalian, Liaoning, China., Ozaki T; Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan., Nakata E; Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan., Fujimura A; Department of Cellular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. fujimura.atsushi@kagawa-u.ac.jp.; Department of Molecular Physiology, Kagawa University Faculty of Medicine, Kagawa, Japan. fujimura.atsushi@kagawa-u.ac.jp. |
| Source: | Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Jan 22; Vol. 11 (1), pp. 26. Date of Electronic Publication: 2026 Jan 22. |
| Publication Type: | Letter |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE; In Process |
| Database: | MEDLINE Ultimate |
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