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Engineered mucus-tethering bispecific nanobodies enhance mucosal immunity against respiratory pathogens.

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Title: Engineered mucus-tethering bispecific nanobodies enhance mucosal immunity against respiratory pathogens.
Authors: Zhao L; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA. zhaolm@stanford.edu.; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA. zhaolm@stanford.edu.; Department of Orthopaedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. zhaolm@stanford.edu., O'Donnell KL; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Dubey M; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA., Wang Y; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.; Department of Orthopaedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Department of Orthopaedic Surgery, University of California, Davis, Sacramento, CA, USA., Martinez NR; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Department of Orthopaedic Surgery, University of California, Davis, Sacramento, CA, USA., Zhang Y; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA., Steininger HM; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA., Ma C; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA., Mallajosyula V; Institute of Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA., Lee LLY; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA., Lachmansingh RN; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA., Stavitsky S; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA., Takematsu E; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA., Hoover MY; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA., Chen H; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA., Guo J; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA., Wu A; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ma Y; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wang X; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Nalin AP; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Jeong SD; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lu WJ; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA., Nguyen PK; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA., Clancy CS; Rocky Mountain Veterinary Branch, Rocky Mountain Laboratories, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Tal MC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Xiao J; Department of Orthopaedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Longaker MT; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA., Lee AS; School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China.; Institute for Cancer Research, Shenzhen Bay Laboratory, Shenzhen, China., Kim BYS; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ambrosi TH; Department of Orthopaedic Surgery, University of California, Davis, Sacramento, CA, USA., Weissman IL; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Davis MM; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.; Institute of Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA., Hasenkrug KJ; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Chien YH; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA. chien@stanford.edu.; Program of Immunology, Stanford University School of Medicine, Stanford, CA, USA. chien@stanford.edu., Jiang W; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. wjiang4@mdanderson.org., Marzi A; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA. marzia@niaid.nih.gov., Chan CKF; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Source: Nature nanotechnology [Nat Nanotechnol] 2026 Mar; Vol. 21 (3), pp. 419-429. Date of Electronic Publication: 2026 Jan 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101283273 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-3395 (Electronic) Linking ISSN: 17483387 NLM ISO Abbreviation: Nat Nanotechnol Subsets: MEDLINE
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